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core protein

  • Open Access
    Preclinical Profile and Characterization of the Hepatitis B Virus Core Protein Inhibitor ABI-H0731
    Antiviral Agents
    Preclinical Profile and Characterization of the Hepatitis B Virus Core Protein Inhibitor ABI-H0731

    ABI-H0731, a first-generation hepatitis B virus (HBV) core protein inhibitor, has demonstrated effective antiviral activity in chronic hepatitis B (CHB) patients in a phase 1b clinical trial and is currently being further evaluated in phase 2 clinical trials. Here, we report the preclinical profile of ABI-H0731. In in vitro cell culture systems (HepG2-derived cell lines HepAD38 and HepG2-NTCP and primary human hepatocytes [PHHs...

    Qi Huang, Dawei Cai, Ran Yan, Lichun Li, Yuhua Zong, Lida Guo, Alexandre Mercier, Yi Zhou, Ariel Tang, Kirk Henne, Richard Colonno
  • A New Role for Capsid Assembly Modulators To Target Mature Hepatitis B Virus Capsids and Prevent Virus Infection
    Antiviral Agents
    A New Role for Capsid Assembly Modulators To Target Mature Hepatitis B Virus Capsids and Prevent Virus Infection

    Hepatitis B virus (HBV) is a major human pathogen, killing an estimated 887,000 people per year. Therefore, potentially curative therapies are of high importance. Following infection, HBV deposits a covalently closed circular DNA (cccDNA) in the nucleus of infected cells that serves as a transcription template and is not affected by current therapies. HBV core protein allosteric modulators (CpAMs) prevent correct capsid assembly but may...

    Chunkyu Ko, Romina Bester, Xue Zhou, Zhiheng Xu, Christoph Blossey, Julia Sacherl, Florian W. R. Vondran, Lu Gao, Ulrike Protzer
  • Identification of Compounds Targeting Hepatitis B Virus Core Protein Dimerization through a Split Luciferase Complementation Assay
    Antiviral Agents
    Identification of Compounds Targeting Hepatitis B Virus Core Protein Dimerization through a Split Luciferase Complementation Assay

    The capsid of the hepatitis B virus is an attractive antiviral target for developing therapies against chronic hepatitis B infection. Currently available core protein allosteric modulators (CpAMs) mainly affect one of the two major types of protein-protein interactions involved in the process of capsid assembly, namely, the interaction between the core dimers.

    Xia-Fei Wei, Chun-Yang Gan, Jing Cui, Ying-Ying Luo, Xue-Fei Cai, Yi Yuan, Jing Shen, Zhi-Ying Li, Wen-Lu Zhang, Quan-Xin Long, Yuan Hu, Juan Chen, Ni Tang, Haitao Guo, Ai-Long Huang, Jie-Li Hu
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