CRE

Epidemiology and Surveillance
Diverse Vectors and Mechanisms Spread New Delhi Metallo-β-Lactamases among Carbapenem-Resistant Enterobacteriaceae in the Greater Boston Area
New Delhi metallo-beta-lactamases (NDMs) are an uncommon but emerging cause of carbapenem resistance in the United States. Genomic factors promoting their domestic spread remain poorly characterized.

Nicole Pecora, Xiaomin Zhao, Kathleen Nudel, Maria Hoffmann, Ning Li, Andrew B. Onderdonk, Deborah Yokoe, Eric Brown, Marc Allard, Lynn Bry
Susceptibility
Synergistic Activity of Colistin-Containing Combinations against Colistin-Resistant Enterobacteriaceae
Resistance to colistin, a polypeptide drug used as an agent of last resort for the treatment of infections caused by multidrug-resistant (MDR) and extensively drug-resistant (XDR) Gram-negative bacteria, including carbapenem-resistant Enterobacteriaceae (CRE), severely limits treatment options and may even transform an XDR organism into one that is pan-resistant. We...

Thea Brennan-Krohn, Alejandro Pironti, James E. Kirby
Mechanisms of Resistance
Colistin Does Not Potentiate Ceftazidime-Avibactam Killing of Carbapenem-Resistant Enterobacteriaceae In Vitro or Suppress Emergence of Ceftazidime-Avibactam Resistance
We tested ceftazidime-avibactam and colistin against 24 carbapenem-resistant Enterobacteriaceae (CRE) isolates by time-kill studies. Ceftazidime-avibactam at 0.25×, 1×, and 4× the MIC was bactericidal against 8%, 21%, and 88% of the isolates, respectively.

Ryan K. Shields, M. Hong Nguyen, Binghua Hao, Ellen G. Kline, Cornelius J. Clancy
Clinical Therapeutics
Pneumonia and Renal Replacement Therapy Are Risk Factors for Ceftazidime-Avibactam Treatment Failures and Resistance among Patients with Carbapenem-Resistant Enterobacteriaceae Infections
Ryan K. Shields, M. Hong Nguyen, Liang Chen, Ellen G. Press, Barry N. Kreiswirth, Cornelius J. Clancy
Epidemiology and Surveillance
Antimicrobial Activities of Aztreonam-Avibactam and Comparator Agents against Contemporary (2016) Clinical Enterobacteriaceae Isolates
Helio S. Sader, Rodrigo E. Mendes, Michael A. Pfaller, Dee Shortridge, Robert K. Flamm, Mariana Castanheira
Epidemiology and Surveillance
Meropenem-Vaborbactam Tested against Contemporary Gram-Negative Isolates Collected Worldwide during 2014, Including Carbapenem-Resistant, KPC-Producing, Multidrug-Resistant, and Extensively Drug-Resistant Enterobacteriaceae
Mariana Castanheira, Michael D. Huband, Rodrigo E. Mendes, Robert K. Flamm
Mechanisms of Resistance
Identifying Spectra of Activity and Therapeutic Niches for Ceftazidime-Avibactam and Imipenem-Relebactam against Carbapenem-Resistant Enterobacteriaceae
Ghady Haidar, Cornelius J. Clancy, Liang Chen, Palash Samanta, Ryan K. Shields, Barry N. Kreiswirth, M. Hong Nguyen
Mechanisms of Resistance
Unusual Escherichia coli PBP 3 Insertion Sequence Identified from a Collection of Carbapenem-Resistant Enterobacteriaceae Tested In Vitro with a Combination of Ceftazidime-, Ceftaroline-, or Aztreonam-Avibactam
Yunliang Zhang, Ankita Kashikar, C. Adam Brown, Gerald Denys, Karen Bush
Epidemiology and Surveillance
WCK 5222 (Cefepime-Zidebactam) Antimicrobial Activity against Clinical Isolates of Gram-Negative Bacteria Collected Worldwide in 2015
Helio S. Sader, Mariana Castanheira, Michael Huband, Ronald N. Jones, Robert K. Flamm
Mechanisms of Resistance
Genomic Characterization of Two KPC-Producing Klebsiella Isolates Collected in 1997 in New York City
Brandon Eilertson, Liang Chen, Kalyan D. Chavda, Barry N. Kreiswirth

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