Skip to main content
  • ASM
    • Antimicrobial Agents and Chemotherapy
    • Applied and Environmental Microbiology
    • Clinical Microbiology Reviews
    • Clinical and Vaccine Immunology
    • EcoSal Plus
    • Eukaryotic Cell
    • Infection and Immunity
    • Journal of Bacteriology
    • Journal of Clinical Microbiology
    • Journal of Microbiology & Biology Education
    • Journal of Virology
    • mBio
    • Microbiology and Molecular Biology Reviews
    • Microbiology Resource Announcements
    • Microbiology Spectrum
    • Molecular and Cellular Biology
    • mSphere
    • mSystems
  • Log in
  • My alerts
  • My Cart

Main menu

  • Home
  • Articles
    • Current Issue
    • Accepted Manuscripts
    • COVID-19 Special Collection
    • Archive
    • Minireviews
  • For Authors
    • Submit a Manuscript
    • Scope
    • Editorial Policy
    • Submission, Review, & Publication Processes
    • Organization and Format
    • Errata, Author Corrections, Retractions
    • Illustrations and Tables
    • Nomenclature
    • Abbreviations and Conventions
    • Publication Fees
    • Ethics Resources and Policies
  • About the Journal
    • About AAC
    • Editor in Chief
    • Editorial Board
    • For Reviewers
    • For the Media
    • For Librarians
    • For Advertisers
    • Alerts
    • AAC Podcast
    • RSS
    • FAQ
  • Subscribe
    • Members
    • Institutions
  • ASM
    • Antimicrobial Agents and Chemotherapy
    • Applied and Environmental Microbiology
    • Clinical Microbiology Reviews
    • Clinical and Vaccine Immunology
    • EcoSal Plus
    • Eukaryotic Cell
    • Infection and Immunity
    • Journal of Bacteriology
    • Journal of Clinical Microbiology
    • Journal of Microbiology & Biology Education
    • Journal of Virology
    • mBio
    • Microbiology and Molecular Biology Reviews
    • Microbiology Resource Announcements
    • Microbiology Spectrum
    • Molecular and Cellular Biology
    • mSphere
    • mSystems

User menu

  • Log in
  • My alerts
  • My Cart

Search

  • Advanced search
Antimicrobial Agents and Chemotherapy
publisher-logosite-logo

Advanced Search

  • Home
  • Articles
    • Current Issue
    • Accepted Manuscripts
    • COVID-19 Special Collection
    • Archive
    • Minireviews
  • For Authors
    • Submit a Manuscript
    • Scope
    • Editorial Policy
    • Submission, Review, & Publication Processes
    • Organization and Format
    • Errata, Author Corrections, Retractions
    • Illustrations and Tables
    • Nomenclature
    • Abbreviations and Conventions
    • Publication Fees
    • Ethics Resources and Policies
  • About the Journal
    • About AAC
    • Editor in Chief
    • Editorial Board
    • For Reviewers
    • For the Media
    • For Librarians
    • For Advertisers
    • Alerts
    • AAC Podcast
    • RSS
    • FAQ
  • Subscribe
    • Members
    • Institutions

CYP51

  • The Antifungal Drug Isavuconazole Is both Amebicidal and Cysticidal against <span class="named-content genus-species" id="named-content-1">Acanthamoeba castellanii</span>
    Experimental Therapeutics
    The Antifungal Drug Isavuconazole Is both Amebicidal and Cysticidal against Acanthamoeba castellanii

    Current treatments for Acanthamoeba keratitis rely on a combination of chlorhexidine gluconate, propamidine isethionate, and polyhexamethylene biguanide. These disinfectants are nonspecific and inherently toxic, which limits their effectiveness. Furthermore, in 10% of cases, recurrent infection ensues due to the difficulty in killing both trophozoites and double-walled cysts. Therefore, development of efficient, safe, and...

    Brian Shing, Seema Singh, Larissa M. Podust, James H. McKerrow, Anjan Debnath
  • Molecular Identification, Antifungal Susceptibility Testing, and Mechanisms of Azole Resistance in <em>Aspergillus</em> Species Received within a Surveillance Program on Antifungal Resistance in Spain
    Susceptibility
    Molecular Identification, Antifungal Susceptibility Testing, and Mechanisms of Azole Resistance in Aspergillus Species Received within a Surveillance Program on Antifungal Resistance in Spain

    Antifungal resistance is one of the major causes of the increasing mortality rates for fungal infections, especially for those caused by Aspergillus spp. A surveillance program was established in 2014 in the Spanish National Center for Microbiology for tracking resistance in the most prevalent Aspergillus species. A total of 273 samples were included in the...

    Olga Rivero-Menendez, Juan Carlos Soto-Debran, Narda Medina, Jose Lucio, Emilia Mellado, Ana Alastruey-Izquierdo
  • New Insights into the Cyp51 Contribution to Azole Resistance in <em>Aspergillus</em> Section <em>Nigri</em>
    Mechanisms of Resistance
    New Insights into the Cyp51 Contribution to Azole Resistance in Aspergillus Section Nigri

    Invasive aspergillosis (IA) is a severe condition mainly caused by Aspergillus fumigatus, although other species of the genus, such as section Nigri members, can also be involved. Voriconazole (VRC) is the recommended treatment for IA; however, the prevalence of azole-resistant Aspergillus isolates has alarmingly increased in recent years, and the...

    Alba Pérez-Cantero, Loida López-Fernández, Josep Guarro, Javier Capilla
  • Azole Resistance Reduces Susceptibility to the Tetrazole Antifungal VT-1161
    Experimental Therapeutics
    Azole Resistance Reduces Susceptibility to the Tetrazole Antifungal VT-1161

    Tetrazole antifungals designed to target fungal lanosterol 14α-demethylase (LDM) appear to be effective against a range of fungal pathogens. In addition, a crystal structure of the catalytic domain of Candida albicans LDM in complex with the tetrazole VT-1161 has been obtained.

    Brian C. Monk, Mikhail V. Keniya, Manya Sabherwal, Rajni K. Wilson, Danyon O. Graham, Harith F. Hassan, Danni Chen, Joel D. A. Tyndall
  • Mechanisms of Resistance
    Identification of 14-α-Lanosterol Demethylase (CYP51) in Scedosporium Species

    Scedosporium spp. cause infections (scedosporiosis) in both immunocompetent and immunocompromised individuals and may persistently colonize the respiratory tract in patients with cystic fibrosis (CF).

    Anne Bernhardt, Wieland Meyer, Volker Rickerts, Toni Aebischer, Kathrin Tintelnot
  • Mechanisms of Resistance
    Molecular Confirmation of the Linkage between the Rhizopus oryzae CYP51A Gene Coding Region and Its Intrinsic Voriconazole and Fluconazole Resistance

    Rhizopus oryzae is the most prevalent causative agent of mucormycosis, an increasingly reported opportunistic fungal infection. These Mucorales are intrinsically resistant to Candida- and Aspergillus-active antifungal azole drugs...

    Daiana Macedo, Florencia Leonardelli, Catiana Dudiuk, Laura Theill, Matías S. Cabeza, Soledad Gamarra, Guillermo Garcia-Effron
  • Open Access
    Pharmacology
    In Vitro and In Vivo Efficacy of a Novel and Long-Acting Fungicidal Azole, PC1244, on Aspergillus fumigatus Infection
    Thomas Colley, Gurpreet Sehra, Anuradha Chowdhary, Alexandre Alanio, Steven L. Kelly, Yasuo Kizawa, Darius Armstrong-James, Matthew C. Fisher, Andrew G. S. Warrilow, Josie E. Parker, Diane E. Kelly, Genki Kimura, Yuki Nishimoto, Mihiro Sunose, Stuart Onions, Damien Crepin, Franz Lagasse, Matthew Crittall, Jonathan Shannon, Matthew McConville, John King-Underwood, Alan Naylor, Stéphane Bretagne, John Murray, Kazuhiro Ito, Pete Strong, Garth Rapeport
  • Mechanisms of Resistance
    Impact of Homologous Resistance Mutations from Pathogenic Yeast on Saccharomyces cerevisiae Lanosterol 14α-Demethylase
    Alia A. Sagatova, Mikhail V. Keniya, Joel D. A. Tyndall, Brian C. Monk
  • Experimental Therapeutics
    The Tetrazole VT-1161 Is a Potent Inhibitor of Trichophyton rubrum through Its Inhibition of T. rubrum CYP51
    Andrew G. S. Warrilow, Josie E. Parker, Claire L. Price, Edward P. Garvey, William J. Hoekstra, Robert J. Schotzinger, Nathan P. Wiederhold, W. David Nes, Diane E. Kelly, Steven L. Kelly
  • Open Access
    Pharmacology
    In Vitro and In Vivo Antifungal Profile of a Novel and Long-Acting Inhaled Azole, PC945, on Aspergillus fumigatus Infection
    Thomas Colley, Alexandre Alanio, Steven L. Kelly, Gurpreet Sehra, Yasuo Kizawa, Andrew G. S. Warrilow, Josie E. Parker, Diane E. Kelly, Genki Kimura, Lauren Anderson-Dring, Takahiro Nakaoki, Mihiro Sunose, Stuart Onions, Damien Crepin, Franz Lagasse, Matthew Crittall, Jonathan Shannon, Michael Cooke, Stéphane Bretagne, John King-Underwood, John Murray, Kazuhiro Ito, Pete Strong, Garth Rapeport
Back to top

About

  • About AAC
  • Editor in Chief
  • Editorial Board
  • Policies
  • For Reviewers
  • For the Media
  • For Librarians
  • For Advertisers
  • Alerts
  • AAC Podcast
  • RSS
  • FAQ
  • Permissions
  • Journal Announcements

Authors

  • ASM Author Center
  • Submit a Manuscript
  • Article Types
  • Ethics
  • Contact Us

Follow #AACJournal

@ASMicrobiology

       

ASM Journals

ASM journals are the most prominent publications in the field, delivering up-to-date and authoritative coverage of both basic and clinical microbiology.

About ASM | Contact Us | Press Room

 

ASM is a member of

Scientific Society Publisher Alliance

 

American Society for Microbiology
1752 N St. NW
Washington, DC 20036
Phone: (202) 737-3600

Copyright © 2021 American Society for Microbiology | Privacy Policy | Website feedback

Print ISSN: 0066-4804; Online ISSN: 1098-6596