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Cytochrome P-450 Enzyme System

  • Mechanisms of Resistance
    Development and Validation of a High-Resolution Melting Assay To Detect Azole Resistance in Aspergillus fumigatus
    L. Bernal-Martínez, H. Gil, O. Rivero-Menéndez, S. Gago, M. Cuenca-Estrella, E. Mellado, A. Alastruey-Izquierdo
  • Susceptibility
    Single-Center Evaluation of an Agar-Based Screening for Azole Resistance in Aspergillus fumigatus by Using VIPcheck
    J. B. Buil, H. A. L. van der Lee, A. J. M. M. Rijs, J. Zoll, J. A. M. F. Hovestadt, W. J. G. Melchers, P. E. Verweij
  • Mechanisms of Resistance
    Drug Sensitivity and Resistance Mechanism in Aspergillus Section Nigri Strains from Japan
    Aki Hashimoto, Daisuke Hagiwara, Akira Watanabe, Maki Yahiro, Alimu Yikelamu, Takashi Yaguchi, Katsuhiko Kamei
  • Free
    Challenging Clinical Case in Antimicrobial Resistance
    Progressive Dispersion of Azole Resistance in Aspergillus fumigatus: Fatal Invasive Aspergillosis in a Patient with Acute Myeloid Leukemia Infected with an A. fumigatus Strain with a cyp51A TR46 Y121F M172I T289A Allele
    Susann Rößler, Oliver Bader, Friedrich Stölzel, Ulrich Sommer, Birgit Spiess, Stephan Geibel, Dieter Buchheidt, Uwe Groß, Gustavo Baretton, Enno Jacobs, Luis Ostrosky-Zeichner
  • Mechanisms of Resistance
    Contributions of both ATP-Binding Cassette Transporter and Cyp51A Proteins Are Essential for Azole Resistance in Aspergillus fumigatus
    Sanjoy Paul, Daniel Diekema, W. Scott Moye-Rowley
  • Experimental Therapeutics
    Antitrypanosomal Activity of Sterol 14α-Demethylase (CYP51) Inhibitors VNI and VFV in the Swiss Mouse Models of Chagas Disease Induced by the Trypanosoma cruzi Y Strain
    F. H. Guedes-da-Silva, D. G. J. Batista, C. F. Da Silva, J. S. De Araújo, B. P. Pavão, M. R. Simões-Silva, M. M. Batista, K. C. Demarque, O. C. Moreira, C. Britto, G. I. Lepesheva, M. N. C. Soeiro
  • Susceptibility
    Complementation of a Saccharomyces cerevisiae ERG11/CYP51 (Sterol 14α-Demethylase) Doxycycline-Regulated Mutant and Screening of the Azole Sensitivity of Aspergillus fumigatus Isoenzymes CYP51A and CYP51B
    Claire M. Martel, Josie E. Parker, Andrew G. S. Warrilow, Nicola J. Rolley, Steven L. Kelly, Diane E. Kelly
  • Experimental Therapeutics
    Impact of cyp51A Mutations on the Pharmacokinetic and Pharmacodynamic Properties of Voriconazole in a Murine Model of Disseminated Aspergillosis
    Eleftheria Mavridou, Roger J. M. Bruggemann, Willem J. G. Melchers, Paul E. Verweij, Johan W. Mouton
  • Susceptibility
    Correlation between Azole Susceptibilities, Genotypes, and ERG11 Mutations in Candida albicans Isolates Associated with Vulvovaginal Candidiasis in China
    Shu-Hua Ge, Zhe Wan, Juan Li, Jianping Xu, Ruo-Yu Li, Feng-Yan Bai
  • Mechanisms of Resistance
    Azole Resistance Profile of Amino Acid Changes in Aspergillus fumigatus CYP51A Based on Protein Homology Modeling
    Eveline Snelders, Anna Karawajczyk, Gijs Schaftenaar, Paul E. Verweij, Willem J. G. Melchers

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