Cytochrome P-450 Enzyme System

Mechanisms of Resistance
Development and Validation of a High-Resolution Melting Assay To Detect Azole Resistance in Aspergillus fumigatus
L. Bernal-Martínez, H. Gil, O. Rivero-Menéndez, S. Gago, M. Cuenca-Estrella, E. Mellado, A. Alastruey-Izquierdo
Susceptibility
Single-Center Evaluation of an Agar-Based Screening for Azole Resistance in Aspergillus fumigatus by Using VIPcheck
J. B. Buil, H. A. L. van der Lee, A. J. M. M. Rijs, J. Zoll, J. A. M. F. Hovestadt, W. J. G. Melchers, P. E. Verweij
Mechanisms of Resistance
Drug Sensitivity and Resistance Mechanism in Aspergillus Section Nigri Strains from Japan
Aki Hashimoto, Daisuke Hagiwara, Akira Watanabe, Maki Yahiro, Alimu Yikelamu, Takashi Yaguchi, Katsuhiko Kamei
Free

Challenging Clinical Case in Antimicrobial Resistance
Progressive Dispersion of Azole Resistance in Aspergillus fumigatus: Fatal Invasive Aspergillosis in a Patient with Acute Myeloid Leukemia Infected with an A. fumigatus Strain with a cyp51A TR₄₆ Y121F M172I T289A Allele
Susann Rößler, Oliver Bader, Friedrich Stölzel, Ulrich Sommer, Birgit Spiess, Stephan Geibel, Dieter Buchheidt, Uwe Groß, Gustavo Baretton, Enno Jacobs, Luis Ostrosky-Zeichner
Mechanisms of Resistance
Contributions of both ATP-Binding Cassette Transporter and Cyp51A Proteins Are Essential for Azole Resistance in Aspergillus fumigatus
Sanjoy Paul, Daniel Diekema, W. Scott Moye-Rowley
Experimental Therapeutics
Antitrypanosomal Activity of Sterol 14α-Demethylase (CYP51) Inhibitors VNI and VFV in the Swiss Mouse Models of Chagas Disease Induced by the Trypanosoma cruzi Y Strain
F. H. Guedes-da-Silva, D. G. J. Batista, C. F. Da Silva, J. S. De Araújo, B. P. Pavão, M. R. Simões-Silva, M. M. Batista, K. C. Demarque, O. C. Moreira, C. Britto, G. I. Lepesheva, M. N. C. Soeiro
Susceptibility
Complementation of a Saccharomyces cerevisiae ERG11/CYP51 (Sterol 14α-Demethylase) Doxycycline-Regulated Mutant and Screening of the Azole Sensitivity of Aspergillus fumigatus Isoenzymes CYP51A and CYP51B
Claire M. Martel, Josie E. Parker, Andrew G. S. Warrilow, Nicola J. Rolley, Steven L. Kelly, Diane E. Kelly
Experimental Therapeutics
Impact of cyp51A Mutations on the Pharmacokinetic and Pharmacodynamic Properties of Voriconazole in a Murine Model of Disseminated Aspergillosis
Eleftheria Mavridou, Roger J. M. Bruggemann, Willem J. G. Melchers, Paul E. Verweij, Johan W. Mouton
Susceptibility
Correlation between Azole Susceptibilities, Genotypes, and ERG11 Mutations in Candida albicans Isolates Associated with Vulvovaginal Candidiasis in China
Shu-Hua Ge, Zhe Wan, Juan Li, Jianping Xu, Ruo-Yu Li, Feng-Yan Bai
Mechanisms of Resistance
Azole Resistance Profile of Amino Acid Changes in Aspergillus fumigatus CYP51A Based on Protein Homology Modeling
Eveline Snelders, Anna Karawajczyk, Gijs Schaftenaar, Paul E. Verweij, Willem J. G. Melchers

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