dimer

  • Identification of Compounds Targeting Hepatitis B Virus Core Protein Dimerization through a Split Luciferase Complementation Assay
    Antiviral Agents
    Identification of Compounds Targeting Hepatitis B Virus Core Protein Dimerization through a Split Luciferase Complementation Assay

    The capsid of the hepatitis B virus is an attractive antiviral target for developing therapies against chronic hepatitis B infection. Currently available core protein allosteric modulators (CpAMs) mainly affect one of the two major types of protein-protein interactions involved in the process of capsid assembly, namely, the interaction between the core dimers.

    Xia-Fei Wei, Chun-Yang Gan, Jing Cui, Ying-Ying Luo, Xue-Fei Cai, Yi Yuan, Jing Shen, Zhi-Ying Li, Wen-Lu Zhang, Quan-Xin Long, Yuan Hu, Juan Chen, Ni Tang, Haitao Guo, Ai-Long Huang, Jie-Li Hu
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