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DNA gyrase

  • Open Access
    Computational Chemogenomics Drug Repositioning Strategy Enables the Discovery of Epirubicin as a New Repurposed Hit for <span class="named-content genus-species" id="named-content-1">Plasmodium falciparum</span> and <span class="named-content genus-species" id="named-content-2">P. vivax</span>
    Experimental Therapeutics
    Computational Chemogenomics Drug Repositioning Strategy Enables the Discovery of Epirubicin as a New Repurposed Hit for Plasmodium falciparum and P. vivax

    Widespread resistance against antimalarial drugs thwarts current efforts for controlling the disease and urges the discovery of new effective treatments. Drug repositioning is increasingly becoming an attractive strategy since it can reduce costs, risks, and time-to-market. Herein, we have used this strategy to identify novel antimalarial hits. We used a comparative in silico chemogenomics approach to select...

    Letícia Tiburcio Ferreira, Juliana Rodrigues, Gustavo Capatti Cassiano, Tatyana Almeida Tavella, Kaira Cristina Peralis Tomaz, Djane Clarys Baia-da-Silva, Macejane Ferreira Souza, Marilia Nunes do Nascimento Lima, Melina Mottin, Ludimila Dias Almeida, Juliana Calit, Maria Carolina Silva de Barros Puça, Gisely Cardoso Melo, Daniel Youssef Bargieri, Stefanie Costa Pinto Lopes, Marcus Vinicius Guimarães Lacerda, Elizabeth Bilsland, Per Sunnerhagen, Bruno Junior Neves, Carolina Horta Andrade, Pedro Vitor Lemos Cravo, Fabio Trindade Maranhão Costa
  • Experimental Therapeutics
    In Vitro and In Vivo Activities of DS-2969b, a Novel GyrB Inhibitor, and Its Water-Soluble Prodrug, DS11960558, against Methicillin-Resistant Staphylococcus aureus
    Tarani Kanta Barman, Manoj Kumar, Tarun Mathur, Eiko Namba, Diksha Singh, Tridib Chaira, Yuichi Kurosaka, Makiko Yamada, Dilip Jatashankar Upadhyay, Nobuhisa Masuda
  • Mechanisms of Resistance
    Molecular Characterization of Fluoroquinolone-Resistant Moraxella catarrhalis Variants Generated In Vitro by Stepwise Selection
    Kageto Yamada, Ryoichi Saito, Saori Muto, Machiko Kashiwa, Yoshiko Tamamori, Shingo Fujisaki
  • Mechanisms of Resistance
    Impact of gyrB and eis Mutations in Improving Detection of Second-Line-Drug Resistance among Mycobacterium tuberculosis Isolates from Georgia
    N. Bablishvili, N. Tukvadze, E. Shashkina, B. Mathema, N. R. Gandhi, H. M. Blumberg, R. R. Kempker
  • Analytical Procedures
    Digital PCR for Detection and Quantification of Fluoroquinolone Resistance in Legionella pneumophila
    Aurélie Hennebique, Marie Bidart, Sophie Jarraud, Laëtitia Beraud, Carole Schwebel, Max Maurin, Sandrine Boisset
  • Mechanisms of Resistance
    Correlation between gyrA and CmeR Box Polymorphism and Fluoroquinolone Resistance in Campylobacter jejuni Isolates in China
    Tengfei Zhang, Yiluo Cheng, Qingping Luo, Qin Lu, Jun Dong, Rongrong Zhang, Guoyuan Wen, Honglin Wang, Ling Luo, Hongcai Wang, Guoping Liu, Huabin Shao
  • Experimental Therapeutics
    Novel Bacterial Topoisomerase Inhibitors with Potent Broad-Spectrum Activity against Drug-Resistant Bacteria
    Cédric Charrier, Anne-Marie Salisbury, Victoria J. Savage, Thomas Duffy, Emmanuel Moyo, Nathan Chaffer-Malam, Nicola Ooi, Rebecca Newman, Jonathan Cheung, Richard Metzger, David McGarry, Mark Pichowicz, Ralph Sigerson, Ian R. Cooper, Gary Nelson, Hayley S. Butler, Mark Craighead, Andrew J. Ratcliffe, Stuart A. Best, Neil R. Stokes
  • Open Access
    Mechanisms of Resistance
    Some Synonymous and Nonsynonymous gyrA Mutations in Mycobacterium tuberculosis Lead to Systematic False-Positive Fluoroquinolone Resistance Results with the Hain GenoType MTBDRsl Assays
    Adebisi Ajileye, Nataly Alvarez, Matthias Merker, Timothy M. Walker, Suriya Akter, Kerstin Brown, Danesh Moradigaravand, Thomas Schön, Sönke Andres, Viola Schleusener, Shaheed V. Omar, Francesc Coll, Hairong Huang, Roland Diel, Nazir Ismail, Julian Parkhill, Bouke C. de Jong, Tim E. A. Peto, Derrick W. Crook, Stefan Niemann, Jaime Robledo, E. Grace Smith, Sharon J. Peacock, Claudio U. Köser
  • Mechanisms of Resistance
    Functional Characterization of the DNA Gyrases in Fluoroquinolone-Resistant Mutants of Francisella novicida
    Yvan Caspar, Claire Siebert, Vivien Sutera, Corinne Villers, Alexandra Aubry, Claudine Mayer, Max Maurin, Patricia Renesto
  • Mechanisms of Resistance
    Fluoroquinolone Resistance in Streptococcus dysgalactiae subsp. equisimilis and Evidence for a Shared Global Gene Pool with Streptococcus pyogenes
    M. D. Pinho, J. Melo-Cristino, M. Ramirez
    and and the Portuguese Group for the Study of Streptococcal Infections

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