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DNA Topoisomerases, Type II

  • Mechanisms of Resistance
    Molecular Evolution Perspectives on Intraspecific Lateral DNA Transfer of Topoisomerase and Gyrase Loci in Streptococcus pneumoniae, with Implications for Fluoroquinolone Resistance Development and Spread
    Michael J. Stanhope, Stacey L. Walsh, Julie A. Becker, Michael J. Italia, Karen A. Ingraham, Michael N. Gwynn, Tom Mathie, James A. Poupard, Linda A. Miller, James R. Brown, Heather Amrine-Madsen
  • Mechanisms of Resistance
    Interspecies Recombination in Type II Topoisomerase Genes Is Not a Major Cause of Fluoroquinolone Resistance in Invasive Streptococcus pneumoniae Isolates in the United States
    Mathias W. R. Pletz, Lesley McGee, Bernard Beall, Cynthia G. Whitney, Keith P. Klugman
  • Mechanisms of Resistance
    Resistance Genes of Aminocoumarin Producers: Two Type II Topoisomerase Genes Confer Resistance against Coumermycin A1 and Clorobiocin
    Elisabeth Schmutz, Agnes Mühlenweg, Shu-Ming Li, Lutz Heide
  • Mechanisms of Action: Physiological Effects
    Importance of the Fourth Alpha-Helix within the CAP Homology Domain of Type II Topoisomerase for DNA Cleavage Site Recognition and Quinolone Action
    Dirk Strumberg, John L. Nitiss, Jiaowang Dong, Jerrylaine Walker, Marc C. Nicklaus, Kurt W. Kohn, Jonathan G. Heddle, Anthony Maxwell, Siegfried Seeber, Yves Pommier
  • Mechanisms of Resistance
    Topoisomerase II and IV Quinolone Resistance-Determining Regions in Stenotrophomonas maltophilia Clinical Isolates with Different Levels of Quinolone Susceptibility
    Sylvia Valdezate, Ana Vindel, Aurora Echeita, Fernando Baquero, Rafael Cantó
  • Mechanisms of Resistance
    Type II Topoisomerase Quinolone Resistance-Determining Regions of Aeromonas caviae, A. hydrophila, and A. sobria Complexes and Mutations Associated with Quinolone Resistance
    Marisol Goñi-Urriza, Corinne Arpin, Michèle Capdepuy, Véronique Dubois, Pierre Caumette, Claudine Quentin
  • Mechanisms of Resistance
    Cleavable-Complex Formation by Wild-Type and Quinolone-Resistant Streptococcus pneumoniae Type II Topoisomerases Mediated by Gemifloxacin and Other Fluoroquinolones
    Genoveva Yague, Julia E. Morris, Xiao-Su Pan, Katherine A. Gould, L. Mark Fisher
  • Susceptibility
    Prevalence of Single Mutations in Topoisomerase Type II Genes among Levofloxacin-Susceptible Clinical Strains of Streptococcus pneumoniae Isolated in the United States in 1992 to 1996 and 1999 to 2000
    Todd A. Davies, Alan Evangelista, Sharon Pfleger, Karen Bush, Daniel F. Sahm, Raul Goldschmidt
  • Mechanisms of Resistance
    Type II Topoisomerase Mutations in Fluoroquinolone-Resistant Clinical Strains of Pseudomonas aeruginosa Isolated in 1998 and 1999: Role of Target Enzyme in Mechanism of Fluoroquinolone Resistance
    Takaaki Akasaka, Mayumi Tanaka, Akihito Yamaguchi, Kenichi Sato
  • Mechanisms of Resistance
    Resistance to Moxifloxacin in ToxigenicClostridium difficile Isolates Is Associated with Mutations in gyrA
    Grit Ackermann, Yajarayma J. Tang, Robert Kueper, Peter Heisig, Arne C. Rodloff, Joseph Silva, Stuart H. Cohen

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