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doxycycline

  • <em>In Vitro</em> Susceptibility of <span class="named-content genus-species" id="named-content-1">Treponema pallidum</span> subsp. <em>pallidum</em> to Doxycycline
    Editor's Pick Susceptibility
    In Vitro Susceptibility of Treponema pallidum subsp. pallidum to Doxycycline

    Doxycycline is regarded as an effective therapy for early syphilis, and there is increasing interest in using doxycycline for prophylaxis of this infection. However, the MIC of doxycycline for Treponema pallidum subsp. pallidum has not been reported previously. In this study, an in vitro culture system was utilized to determine that the MIC of...

    Diane G. Edmondson, Gary P. Wormser, Steven J. Norris
  • Open Access
    Tissue Distribution of Doxycycline in Animal Models of Tuberculosis
    Pharmacology
    Tissue Distribution of Doxycycline in Animal Models of Tuberculosis

    Doxycycline, an FDA-approved tetracycline, is used in tuberculosis in vivo models for the temporal control of mycobacterial gene expression. In these models, animals are infected with recombinant Mycobacterium tuberculosis carrying genes of interest under transcriptional control of the doxycycline-responsive TetR-tetO unit. To minimize fluctuations...

    Martin Gengenbacher, Matthew D. Zimmerman, Jansy P. Sarathy, Firat Kaya, Han Wang, Marizel Mina, Claire Carter, Md Amir Hossen, Hongwei Su, Carolina Trujillo, Sabine Ehrt, Dirk Schnappinger, Véronique Dartois
  • Insecticidal Activity of Doxycycline against the Common Bedbug
    Experimental Therapeutics
    Insecticidal Activity of Doxycycline against the Common Bedbug

    There is an ongoing need for safe and effective anti-bedbug compounds. Here, we tested the toxicity of three antimicrobial agents against bedbugs when administered orally. We reveal that doxycycline has direct insecticidal activity at 250 μg/ml (0.025%) that is particularly strong against immature bedbugs and appears to be independent of antimicrobial activity. Future studies to determine the mechanisms behind this property could be...

    Jose E. Pietri, Dangsheng Liang
  • Open Access
    Activation of Heme Oxygenase Expression by Cobalt Protoporphyrin Treatment Prevents Pneumonic Plague Caused by Inhalation of <em>Yersinia pestis</em>
    Experimental Therapeutics
    Activation of Heme Oxygenase Expression by Cobalt Protoporphyrin Treatment Prevents Pneumonic Plague Caused by Inhalation of Yersinia pestis

    Pneumonic plague, caused by the Gram-negative bacteria Yersinia pestis, is an invasive, rapidly progressing disease with poor survival rates. Following inhalation of Y. pestis, bacterial invasion of the lungs and a tissue-damaging inflammatory response allows vascular spread of the infection....

    Joshua L. Willix, Jacob L. Stockton, Rachel M. Olson, Paul E. Anderson, Deborah M. Anderson
  • Population Pharmacokinetics of Doxycycline in Children
    Pharmacology
    Population Pharmacokinetics of Doxycycline in Children

    Doxycycline is a tetracycline-class antimicrobial labeled by the U.S. Food and Drug Administration for children >8 years of age for many common childhood infections. Doxycycline is not labeled for children ≤8 years of age, due to the association between tetracycline-class antibiotics and tooth staining, although doxycycline may be used off-label under severe conditions.

    Elizabeth J. Thompson, Huali Wu, Chiara Melloni, Stephen Balevic, Janice E. Sullivan, Matthew Laughon, Kira M. Clark, Rohit Kalra, Susan Mendley, Elizabeth H. Payne, Jinson Erinjeri, Casey E. Gelber, Barrie Harper, Michael Cohen-Wolkowiez, Christoph P. Hornik
  • Kinetic Driver of Antibacterial Drugs against <em>Plasmodium falciparum</em> and Implications for Clinical Dosing
    Pharmacology
    Kinetic Driver of Antibacterial Drugs against Plasmodium falciparum and Implications for Clinical Dosing

    Antibacterial drugs are an important component of malaria therapy. We studied the interactions of clindamycin, tetracycline, chloramphenicol, and ciprofloxacin against Plasmodium falciparum under static and dynamic conditions. In microtiter plate assays (static conditions), and as expected, parasites displayed the delayed death response characteristic for apicoplast-...

    Emily Caton, Elizabeth Nenortas, Rahul P. Bakshi, Theresa A. Shapiro
  • Open Access
    Microbiological Profile of Sarecycline, a Novel Targeted Spectrum Tetracycline for the Treatment of Acne Vulgaris
    Clinical Therapeutics
    Microbiological Profile of Sarecycline, a Novel Targeted Spectrum Tetracycline for the Treatment of Acne Vulgaris

    Sarecycline is the first narrow-spectrum tetracycline-class antibiotic being developed for acne treatment. In addition to exhibiting activity against important skin/soft tissue pathogens, sarecycline exhibits targeted antibacterial activity against clinical isolates of Cutibacterium acnes.

    George Zhanel, Ian Critchley, Lynn-Yao Lin, Nancy Alvandi
  • Prospective Cohort Study of Single-Day Doxycycline Therapy for Mediterranean Spotted Fever
    Clinical Therapeutics
    Prospective Cohort Study of Single-Day Doxycycline Therapy for Mediterranean Spotted Fever

    The objective of this study is to evaluate the results of single-day doxycycline therapy for Mediterranean spotted fever (MSF). This is a prospective cohort study of cases with confirmed MSF treated with the single-day doxycycline regimen in a teaching hospital from 1990 to 2015.

    Elena Espejo, Marta Andrés, Maria-Consol Garcia, Anna Fajardo, Josefa Pérez, Feliu Bella
  • Susceptibility
    Efficacy of Ceftriaxone, Cefepime, Doxycycline, Ciprofloxacin, and Combination Therapy for Vibrio vulnificus Foodborne Septicemia
    Sonya A. Trinh, Hannah E. Gavin, Karla J. F. Satchell
  • Susceptibility
    In Vitro Susceptibility of the Relapsing-Fever Spirochete Borrelia miyamotoi to Antimicrobial Agents
    Joris Koetsveld, Ronald O. P. Draga, Alex Wagemakers, Annemijn Manger, Anneke Oei, Caroline E. Visser, Joppe W. Hovius

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