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drug interaction

  • Open Access
    Safety, Tolerability, Pharmacokinetics, and Drug Interaction Potential of SPR741, an Intravenous Potentiator, after Single and Multiple Ascending Doses and When Combined with β-Lactam Antibiotics in Healthy Subjects
    Clinical Therapeutics
    Safety, Tolerability, Pharmacokinetics, and Drug Interaction Potential of SPR741, an Intravenous Potentiator, after Single and Multiple Ascending Doses and When Combined with β-Lactam Antibiotics in Healthy Subjects

    SPR741 is a novel polymyxin B derivative, with minimal intrinsic antibacterial activity and reduced nonclinical nephrotoxicity compared to levels with polymyxin B, that interacts with the outer membrane of Gram-negative bacteria, enhancing penetration of coadministered antibiotics.

    Paul B. Eckburg, Troy Lister, Susannah Walpole, Tim Keutzer, Luke Utley, John Tomayko, Ellen Kopp, Nicholas Farinola, Scott Coleman
  • Open Access
    Mass Balance and Drug Interaction Potential of Intravenous Eravacycline Administered to Healthy Subjects
    Pharmacology
    Mass Balance and Drug Interaction Potential of Intravenous Eravacycline Administered to Healthy Subjects

    Eravacycline is a novel, fully synthetic fluorocycline that is approved for the treatment of complicated intra-abdominal infections (cIAI) in adult patients. We report results from three studies in healthy subjects that investigated the distribution, metabolism, and excretion of intravenous (i.v.) eravacycline and the effect of a CYP3A4 inhibitor (itraconazole) and inducer (rifampin) on the pharmacokinetics (PK) of i.v.

    ...
    Joseph V. Newman, Jian Zhou, Sergey Izmailyan, Larry Tsai
  • <em>In Vitro</em> and <em>In Vivo</em> Drug-Drug Interaction Study of the Effects of Ivermectin and Oxantel Pamoate on Tribendimidine
    Experimental Therapeutics
    In Vitro and In Vivo Drug-Drug Interaction Study of the Effects of Ivermectin and Oxantel Pamoate on Tribendimidine

    Soil-transmitted helminth (STH) infections still remain a major health problem in poor rural settings. The lack of efficacious drugs against all STH species raises interest in drug combinations.

    Anna Neodo, Jessica D. Schulz, Jörg Huwyler, Jennifer Keiser
  • Clinical Therapeutics
    Phase 1 Study of the Safety, Tolerability, and Pharmacokinetics of Vaborbactam and Meropenem Alone and in Combination following Single and Multiple Doses in Healthy Adult Subjects
    Christopher M. Rubino, Sujata M. Bhavnani, Jeffery S. Loutit, Elizabeth E. Morgan, Dan White, Michael N. Dudley, David C. Griffith
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