drug-resistant tuberculosis

  • Open Access
    Cycloserine Population Pharmacokinetics and Pharmacodynamics in Patients with Tuberculosis
    Clinical Therapeutics
    Cycloserine Population Pharmacokinetics and Pharmacodynamics in Patients with Tuberculosis

    Limited pharmacokinetic/pharmacodynamic (PK/PD) data exist on cycloserine in tuberculosis (TB) patients. We pooled several studies into a large PK data set to estimate the population PK parameters for cycloserine in TB patients.

    Wael A. Alghamdi, Abdullah Alsultan, Mohammad H. Al-Shaer, Guohua An, Shahriar Ahmed, Yosra Alkabab, Sayera Banu, Ketevan Barbakadze, Eric Houpt, Maia Kipiani, Lali Mikiashvili, Stephan Schmidt, Scott K. Heysell, Russell R. Kempker, J. Peter Cegielski, Charles A. Peloquin
  • Linezolid Pharmacokinetics in South African Patients with Drug-Resistant Tuberculosis and a High Prevalence of HIV Coinfection
    Clinical Therapeutics
    Linezolid Pharmacokinetics in South African Patients with Drug-Resistant Tuberculosis and a High Prevalence of HIV Coinfection

    The World Health Organization (WHO) recently recommended that linezolid be prioritized in treatment regimens for drug-resistant tuberculosis (TB), but there are limited data on its pharmacokinetics (PK) in patients with this disease. We conducted an observational study to explore covariate effects on linezolid PK and to estimate the probability of PK/pharmacodynamic target attainment in South African patients with drug-resistant TB....

    Sean Wasserman, Paolo Denti, James C. M. Brust, Mahmoud Abdelwahab, Siphokazi Hlungulu, Lubbe Wiesner, Jennifer Norman, Frederick A. Sirgel, Robin M. Warren, Aliasgar Esmail, Keertan Dheda, Neel R. Gandhi, Graeme Meintjes, Gary Maartens
  • Mechanisms of Resistance
    Mycobacterium tuberculosis Subculture Results in Loss of Potentially Clinically Relevant Heteroresistance
    John Z. Metcalfe, Elizabeth Streicher, Grant Theron, Rebecca E. Colman, Renee Penaloza, Christopher Allender, Darrin Lemmer, Robin M. Warren, David M. Engelthaler
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