dysbiosis
PharmacologyImpact of Antibiotic Gut Exposure on the Temporal Changes in Microbiome DiversityAlthough the global deleterious impact of antibiotics on the intestinal microbiota is well known, temporal changes in microbial diversity during and after an antibiotic treatment are still poorly characterized. We used plasma and fecal samples collected frequently during treatment and up to one month after from 22 healthy volunteers assigned to a 5-day treatment by moxifloxacin (n = 14) or no intervention (n = 8)....
Mechanisms of Action: Physiological EffectsAntibiotic-Induced Dysbiosis Predicts Mortality in an Animal Model of Clostridium difficile InfectionAntibiotic disruption of the intestinal microbiota favors colonization by Clostridium difficile. Using a charcoal-based adsorbent to decrease intestinal antibiotic concentrations, we studied the relationship between antibiotic concentrations in feces and the intensity of dysbiosis and quantified the link between this intensity and mortality.