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dysbiosis

  • Optimization of an Assay To Determine Colonization Resistance to <span class="named-content genus-species" id="named-content-1">Clostridioides difficile</span> in Fecal Samples from Healthy Subjects and Those Treated with Antibiotics
    Clinical Therapeutics
    Optimization of an Assay To Determine Colonization Resistance to Clostridioides difficile in Fecal Samples from Healthy Subjects and Those Treated with Antibiotics

    A healthy, intact gut microbiota is often resistant to colonization by gastrointestinal pathogens. During periods of dysbiosis, however, organisms such as Clostridioides difficile can thrive. We describe an optimized in vitro colonization resistance assay for C. difficile in stool (CRACS)...

    Hannah C. Harris, Emma L. Best, Charmaine Normington, Nathalie Saint-Lu, Frédérique Sablier-Gallis, Jean de Gunzburg, Antoine Andremont, Mark H. Wilcox, Caroline H. Chilton
  • DAV131A Protects Hamsters from Lethal <em>Clostridioides difficile</em> Infection Induced by Fluoroquinolones
    Mechanisms of Action: Physiological Effects
    DAV131A Protects Hamsters from Lethal Clostridioides difficile Infection Induced by Fluoroquinolones

    Fluoroquinolone treatments induce dysbiosis of the intestinal microbiota, resulting in loss of resistance to colonization by exogenous bacteria such as Clostridioides difficile that may cause severe diarrhea in humans and lethal infection in hamsters. We show here that DAV131A, a charcoal-based adsorbent, decreases the intestinal levels of the fluoroquinolone...

    Nathalie Saint-Lu, Charles Burdet, Frédérique Sablier-Gallis, Tanguy Corbel, Agathe Nevière, Sakina Sayah-Jeanne, Mark Pulse, William Weiss, Stéphanie Ferreira, Antoine Andremont, France Mentré, Jean de Gunzburg
  • Impact of Antibiotic Gut Exposure on the Temporal Changes in Microbiome Diversity
    Pharmacology
    Impact of Antibiotic Gut Exposure on the Temporal Changes in Microbiome Diversity

    Although the global deleterious impact of antibiotics on the intestinal microbiota is well known, temporal changes in microbial diversity during and after an antibiotic treatment are still poorly characterized. We used plasma and fecal samples collected frequently during treatment and up to one month after from 22 healthy volunteers assigned to a 5-day treatment by moxifloxacin (n = 14) or no intervention (n = 8)....

    Charles Burdet, Thu Thuy Nguyen, Xavier Duval, Stéphanie Ferreira, Antoine Andremont, Jérémie Guedj, France Mentré, the DAV132-CL-1002 Study Group
  • Antibiotic-Induced Dysbiosis Predicts Mortality in an Animal Model of <span class="named-content genus-species" id="named-content-1">Clostridium difficile</span> Infection
    Mechanisms of Action: Physiological Effects
    Antibiotic-Induced Dysbiosis Predicts Mortality in an Animal Model of Clostridium difficile Infection

    Antibiotic disruption of the intestinal microbiota favors colonization by Clostridium difficile. Using a charcoal-based adsorbent to decrease intestinal antibiotic concentrations, we studied the relationship between antibiotic concentrations in feces and the intensity of dysbiosis and quantified the link between this intensity and mortality.

    Charles Burdet, Sakina Sayah-Jeanne, Thu Thuy Nguyen, Perrine Hugon, Frédérique Sablier-Gallis, Nathalie Saint-Lu, Tanguy Corbel, Stéphanie Ferreira, Mark Pulse, William Weiss, Antoine Andremont, France Mentré, Jean de Gunzburg
  • Experimental Therapeutics
    Protection of Hamsters from Mortality by Reducing Fecal Moxifloxacin Concentration with DAV131A in a Model of Moxifloxacin-Induced Clostridium difficile Colitis
    Charles Burdet, Sakina Sayah-Jeanne, Thu Thuy Nguyen, Christine Miossec, Nathalie Saint-Lu, Mark Pulse, William Weiss, Antoine Andremont, France Mentré, Jean de Gunzburg
  • Open Access
    Experimental Therapeutics
    The Oral β-Lactamase SYN-004 (Ribaxamase) Degrades Ceftriaxone Excreted into the Intestine in Phase 2a Clinical Studies
    John F. Kokai-Kun, Tracey Roberts, Olivia Coughlin, Eric Sicard, Marianne Rufiange, Richard Fedorak, Christian Carter, Marijke H. Adams, James Longstreth, Heidi Whalen, Joseph Sliman
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