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endocarditis

  • Is Once-Daily High-Dose Ceftriaxone plus Ampicillin an Alternative for <span class="named-content genus-species" id="named-content-1">Enterococcus faecalis</span> Infective Endocarditis in Outpatient Parenteral Antibiotic Therapy Programs?
    Experimental Therapeutics
    Is Once-Daily High-Dose Ceftriaxone plus Ampicillin an Alternative for Enterococcus faecalis Infective Endocarditis in Outpatient Parenteral Antibiotic Therapy Programs?

    Ceftriaxone administered as once-daily high-dose short infusion combined with ampicillin has been proposed for the treatment of Enterococcus faecalis infective endocarditis in outpatient parenteral antibiotic therapy programs (OPAT). This combination requires synergistic activity, but the attainment of ceftriaxone synergic concentration (Cs) with the regimen proposed...

    Laura Herrera-Hidalgo, Arístides de Alarcón, Luis Eduardo López-Cortes, Rafael Luque-Márquez, Luis Fernando López-Cortes, Alicia Gutiérrez-Valencia, María Victoria Gil-Navarro
    and on behalf of Grupo para el Estudio de las Infecciones Cardiovasculares de la Sociedad Andaluza de Enfermedades Infecciosas
  • Effect of the Lysin Exebacase on Cardiac Vegetation Progression in a Rabbit Model of Methicillin-Resistant <span class="named-content genus-species" id="named-content-1">Staphylococcus aureus</span> Endocarditis as Determined by Echocardiography
    Pharmacology
    Effect of the Lysin Exebacase on Cardiac Vegetation Progression in a Rabbit Model of Methicillin-Resistant Staphylococcus aureus Endocarditis as Determined by Echocardiography

    Methicillin-resistant Staphylococcus aureus (MRSA) poses significant therapeutic challenges related to its frequency in clinical infections, innate virulence properties, and propensity for multiantibiotic resistance. MRSA is among the most common causes of endovascular infections, including infective endocarditis (IE). Our objective was to employ transthoracic...

    Sonia U. Shah, Yan Q. Xiong, Wessam Abdelhady, James Iwaz, Youngju Pak, Raymond Schuch, Cara Cassino, Dario Lehoux, Arnold S. Bayer
  • Distinct Subpopulations of Intravalvular Methicillin-Resistant <span class="named-content genus-species" id="named-content-1">Staphylococcus aureus</span> with Variable Susceptibility to Daptomycin in Tricuspid Valve Endocarditis
    Mechanisms of Resistance
    Distinct Subpopulations of Intravalvular Methicillin-Resistant Staphylococcus aureus with Variable Susceptibility to Daptomycin in Tricuspid Valve Endocarditis

    We present a case of endocarditis wherein organisms cultured from different valve leaflets yielded different daptomycin susceptibilities from each other and from organisms obtained from peripheral blood culture. Genomic analyses showed mutations in mprF, purR, and agrA. Pharmacokinetic simulations showed consistent activity of daptomycin plus beta-lactam against all subpopulations.

    Christopher R. Miller, Somrita Dey, Paula D. Smolenski, Pushkar S. Kulkarni, Jonathan M. Monk, Richard Szubin, George Sakoulas, Andrew D. Berti
  • Relationship between Vancomycin MIC and Virulence Gene Expression in Clonal Complexes of Methicillin-Susceptible <span class="named-content genus-species" id="named-content-1">Staphylococcus aureus</span> Strains Isolated from Left-Sided Endocarditis
    Clinical Therapeutics
    Relationship between Vancomycin MIC and Virulence Gene Expression in Clonal Complexes of Methicillin-Susceptible Staphylococcus aureus Strains Isolated from Left-Sided Endocarditis

    Higher vancomycin MICs have been associated with more complicated courses and higher mortality rates in patients with Staphylococcus aureus bacteremia and infective endocarditis (IE).

    Juan M. Pericàs, Carlos Cervera, Cristina Garcia-de-la-Mària, Batu K. Sharma-Kuinkel, Rachelle Gonzales, Asunción Moreno, Manel Almela, Carlos Falces, Eduard Quintana, David Fuster, Francesc Marco, Arnold S. Bayer, Vance G. Fowler, José M. Miró
    and the Hospital Clinic Endocarditis Study Group
  • Experimental Therapeutics
    The Combination of Daptomycin and Fosfomycin Has Synergistic, Potent, and Rapid Bactericidal Activity against Methicillin-Resistant Staphylococcus aureus in a Rabbit Model of Experimental Endocarditis
    Cristina García-de-la-Mària, Oriol Gasch, Javier García-Gonzalez, Dolors Soy, Evelyn Shaw, Juan Ambrosioni, Manel Almela, Juan M. Pericàs, Adrián Tellez, Carlos Falces, Marta Hernandez-Meneses, Elena Sandoval, Eduard Quintana, Barbara Vidal, Jose M. Tolosana, David Fuster, Jaume Llopis, Miquel Pujol, Asuncion Moreno, Francesc Marco, Jose M. Miró
    and the Hospital Clinic Endocarditis Study Group
  • Experimental Therapeutics
    A Human Biofilm-Disrupting Monoclonal Antibody Potentiates Antibiotic Efficacy in Rodent Models of both Staphylococcus aureus and Acinetobacter baumannii Infections
    Yan Q. Xiong, Angeles Estellés, L. Li, W. Abdelhady, R. Gonzales, Arnold S. Bayer, Edgar Tenorio, Anton Leighton, Stefan Ryser, Lawrence M. Kauvar
  • Experimental Therapeutics
    Efficacy of Ceftaroline against Methicillin-Susceptible Staphylococcus aureus Exhibiting the Cefazolin High-Inoculum Effect in a Rat Model of Endocarditis
    Kavindra V. Singh, Truc T. Tran, Esteban C. Nannini, Vincent H. Tam, Cesar A. Arias, Barbara E. Murray
  • Experimental Therapeutics
    AUC/MIC Pharmacodynamic Target Is Not a Good Predictor of Vancomycin Efficacy in Methicillin-Resistant Staphylococcus aureus Experimental Endocarditis
    Ximena Castañeda, Cristina García-de-la-Mària, Oriol Gasch, Juan M. Pericas, Yolanda Armero, Dolors Soy, Javier García-González, Carlos Falces, Salvador Ninot, Manel Almela, Juan Ambrosioni, Eduardo Quintana, Barbara Vidal, David Fuster, Jaume Llopis, Sara Soto, Asuncion Moreno, Francesc Marco, Jose M. Miró, the Hospital Clinic Endocarditis Study Group
  • Experimental Therapeutics
    Pharmacodynamics of Ceftaroline plus Ampicillin against Enterococcus faecalis in an In Vitro Pharmacokinetic/Pharmacodynamic Model of Simulated Endocardial Vegetations
    Brian J. Werth, Laura M. Shireman
  • Free
    Challenging Clinical Case in Antimicrobial Resistance
    Ceftaroline-Resistant, Daptomycin-Tolerant, and Heterogeneous Vancomycin-Intermediate Methicillin-Resistant Staphylococcus aureus Causing Infective Endocarditis
    Masayuki Nigo, Lorena Diaz, Lina P. Carvajal, Truc T. Tran, Rafael Rios, Diana Panesso, Juan D. Garavito, William R. Miller, Audrey Wanger, George Weinstock, Jose M. Munita, Cesar A. Arias, Henry F. Chambers

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