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endolysin

  • Lysocins: Bioengineered Antimicrobials That Deliver Lysins across the Outer Membrane of Gram-Negative Bacteria
    Editor's Pick Experimental Therapeutics
    Lysocins: Bioengineered Antimicrobials That Deliver Lysins across the Outer Membrane of Gram-Negative Bacteria

    The prevalence of multidrug-resistant Pseudomonas aeruginosa has stimulated development of alternative therapeutics. Bacteriophage peptidoglycan hydrolases, termed lysins, represent an emerging antimicrobial option for targeting Gram-positive bacteria.

    Ryan D. Heselpoth, Chad W. Euler, Raymond Schuch, Vincent A. Fischetti
  • ClyJ Is a Novel Pneumococcal Chimeric Lysin with a Cysteine- and Histidine-Dependent Amidohydrolase/Peptidase Catalytic Domain
    Experimental Therapeutics
    ClyJ Is a Novel Pneumococcal Chimeric Lysin with a Cysteine- and Histidine-Dependent Amidohydrolase/Peptidase Catalytic Domain

    Streptococcus pneumoniae is one of the leading pathogens that cause a variety of mucosal and invasive infections. With the increased emergence of multidrug-resistant S. pneumoniae, new antimicrobials with mechanisms of action different from conventional antibiotics are urgently needed.

    ...
    Hang Yang, Yujing Gong, Huaidong Zhang, Irina Etobayeva, Paulina Miernikiewicz, Dehua Luo, Xiaohong Li, Xiaoxu Zhang, Krystyna DÄ…browska, Daniel C. Nelson, Jin He, Hongping Wei
  • Effects of Phage Endolysin SAL200 Combined with Antibiotics on <span class="named-content genus-species" id="named-content-1">Staphylococcus aureus</span> Infection
    Clinical Therapeutics
    Effects of Phage Endolysin SAL200 Combined with Antibiotics on Staphylococcus aureus Infection

    Phages and their derivatives are increasingly being reconsidered for use in the treatment of bacterial infections due to the rising rates of antibiotic resistance. We assessed the antistaphylococcal effect of the endolysin SAL200 in combination with standard-of-care (SOC) antibiotics.

    Nak-Hyun Kim, Wan Beom Park, Jeong Eun Cho, Yoon Jeong Choi, Su Jin Choi, Soo Youn Jun, Chang Kyung Kang, Kyoung-Ho Song, Pyoeng Gyun Choe, Ji-Hwan Bang, Eu Suk Kim, Sang Won Park, Nam-Joong Kim, Myoung-don Oh, Hong Bin Kim
  • Susceptibility
    The Novel Phage-Derived Antimicrobial Agent HY-133 Is Active against Livestock-Associated Methicillin-Resistant Staphylococcus aureus
    Ursula Kaspar, Jorge A. de Haro Sautto, Sonja Molinaro, Georg Peters, Evgeny A. Idelevich, Karsten Becker
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