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Enterobacter cloacae

  • <em>In Vitro</em> Pharmacodynamics of Fosfomycin against Carbapenem-Resistant <span class="named-content genus-species" id="named-content-1">Enterobacter cloacae</span> and <span class="named-content genus-species" id="named-content-2">Klebsiella aerogenes</span>
    Experimental Therapeutics
    In Vitro Pharmacodynamics of Fosfomycin against Carbapenem-Resistant Enterobacter cloacae and Klebsiella aerogenes

    The increase of carbapenem-resistant Enterobacterales (CRE) and lack of therapeutic options due to the scarcity of new antibiotics has sparked interest toward the use of intravenous fosfomycin against systemic CRE infections. We aimed to investigate the in vitro pharmacodynamics of fosfomycin against carbapenem-resistant Enterobacter cloacae and...

    Tze-Peng Lim, Jocelyn Qi-Min Teo, Audrey Wei-Ling Goh, Si-Xuan Tan, Tse-Hsien Koh, Winnie Hui-Ling Lee, Yiying Cai, Thuan-Tong Tan, Andrea Lay-Hoon Kwa
  • Ceftazidime-Avibactam Resistance Mediated by the N<sup>346</sup>Y Substitution in Various AmpC β-Lactamases
    Mechanisms of Resistance
    Ceftazidime-Avibactam Resistance Mediated by the N346Y Substitution in Various AmpC β-Lactamases

    Chromosomal and plasmid-borne AmpC cephalosporinases are a major resistance mechanism to β-lactams in Enterobacteriaceae and Pseudomonas aeruginosa. The new β-lactamase inhibitor avibactam effectively inhibits class C enzymes and can fully restore ceftazidime susceptibility. The conserved amino acid residue Asn346 of AmpC cephalosporinases directly...

    Fabrice Compain, Agathe Debray, Pauline Adjadj, Delphine Dorchêne, Michel Arthur
  • Mechanisms of Resistance
    Kinetics of Sulbactam Hydrolysis by β-Lactamases, and Kinetics of β-Lactamase Inhibition by Sulbactam
    Adam B. Shapiro
  • Experimental Therapeutics
    Inhibition of Fosfomycin Resistance Protein FosA by Phosphonoformate (Foscarnet) in Multidrug-Resistant Gram-Negative Pathogens
    Ryota Ito, Adam D. Tomich, Christi L. McElheny, Roberta T. Mettus, Nicolas Sluis-Cremer, Yohei Doi
  • Mechanisms of Resistance
    Enterobacter cloacae Complex Isolates Harboring blaNMC-A or blaIMI-Type Class A Carbapenemase Genes on Novel Chromosomal Integrative Elements and Plasmids
    David A. Boyd, Laura F. Mataseje, Ross Davidson, Johannes A. Delport, Jeff Fuller, Linda Hoang, Brigitte Lefebvre, Paul N. Levett, Diane L. Roscoe, Barbara M. Willey, Michael R. Mulvey
  • Epidemiology and Surveillance
    A Prolonged Outbreak of KPC-3-Producing Enterobacter cloacae and Klebsiella pneumoniae Driven by Multiple Mechanisms of Resistance Transmission at a Large Academic Burn Center
    Hajime Kanamori, Christian M. Parobek, Jonathan J. Juliano, David van Duin, Bruce A. Cairns, David J. Weber, William A. Rutala
  • Clinical Therapeutics
    Bacteremia Due to Extended-Spectrum-β-Lactamase-Producing Enterobacter cloacae: Role of Carbapenem Therapy
    Ching-Chi Lee, Nan-Yao Lee, Jing-Jou Yan, Hsin-Chun Lee, Po-Lin Chen, Chia-Ming Chang, Chi-Jung Wu, Nai-Ying Ko, Li-Rong Wang, Chih-Hsien Chi, Wen-Chien Ko
  • Mechanisms of Resistance
    Integron Mobilization Unit as a Source of Mobility of Antibiotic Resistance Genes
    Laurent Poirel, Amélie Carrër, Johann D. Pitout, Patrice Nordmann
  • Mechanisms of Resistance
    KPC-2-Producing Enterobacter cloacae and Pseudomonas putida Coinfection in a Liver Transplant Recipient
    Jason W. Bennett, Monica L. Herrera, James S. Lewis, Brian W. Wickes, James H. Jorgensen
  • Mechanisms of Resistance
    Genetic and Structural Insights into the Dissemination Potential of the Extremely Broad-Spectrum Class A β-Lactamase KPC-2 Identified in an Escherichia coli Strain and an Enterobacter cloacae Strain Isolated from the Same Patient in France
    Stephanie Petrella, Nathalie Ziental-Gelus, Claudine Mayer, Murielle Renard, Vincent Jarlier, Wladimir Sougakoff

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