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Enterobacteriaceae

  • Open Access
    <em>In Vitro</em> Activity of Cefiderocol, a Siderophore Cephalosporin, against Multidrug-Resistant Gram-Negative Bacteria
    Susceptibility
    In Vitro Activity of Cefiderocol, a Siderophore Cephalosporin, against Multidrug-Resistant Gram-Negative Bacteria

    Cefiderocol is a parenteral siderophore cephalosporin with a catechol-containing 3′ substituent. We evaluated its MICs against Gram-negative bacteria, using iron-depleted Mueller-Hinton broth. The panel comprised 305 isolates of Enterobacterales, 111 of Pseudomonas aeruginosa, and 99 of ...

    Shazad Mushtaq, Zahra Sadouki, Anna Vickers, David M. Livermore, Neil Woodford
  • Pharmacodynamics of the Novel Metallo-β-Lactamase Inhibitor ANT2681 in Combination with Meropenem for the Treatment of Infections Caused by NDM-Producing <em>Enterobacteriaceae</em>
    Pharmacology
    Pharmacodynamics of the Novel Metallo-β-Lactamase Inhibitor ANT2681 in Combination with Meropenem for the Treatment of Infections Caused by NDM-Producing Enterobacteriaceae

    Enterobacteriaceae that produce metallo-β-lactamases (MBLs) are an emerging threat to public health. The metallo-β-lactamase inhibitor (MBLi) ANT2681 inhibits the enzymatic activity of MBLs through interaction with the dinuclear zinc ion cluster present in the active site that is common to these enzymes. ANT2681 is being codeveloped, with meropenem as the partner β-lactam, as a novel combination therapy for infections caused by...

    Shampa Das, Adam Johnson, Laura McEntee, Nicola Farrington, Adam Kirby, Jennifer Unsworth, Ana Jimenez-Valverde, Ruwanthi Kolamunnage-Dona, Justine Bousquet, Laethitia Alibaud, Carole Sable, Magdalena Zalacain, Martin Everett, William Hope
  • National Surveillance of Antimicrobial Susceptibility of Bacteremic Gram-Negative Bacteria with Emphasis on Community-Acquired Resistant Isolates: Report from the 2019 Surveillance of Multicenter Antimicrobial Resistance in Taiwan (SMART)
    Epidemiology and Surveillance
    National Surveillance of Antimicrobial Susceptibility of Bacteremic Gram-Negative Bacteria with Emphasis on Community-Acquired Resistant Isolates: Report from the 2019 Surveillance of Multicenter Antimicrobial Resistance in Taiwan (SMART)

    A multicenter collection of bacteremic isolates of Escherichia coli (n = 423), Klebsiella pneumoniae (n = 372), Pseudomonas aeruginosa (n = 300), and...

    Po-Yu Liu, Yu-Lin Lee, Min-Chi Lu, Pei-Lan Shao, Po-Liang Lu, Yen-Hsu Chen, Shu-Hsing Cheng, Wen-Chien Ko, Chi-Ying Lin, Ting-Shu Wu, Muh-Yong Yen, Lih-Shinn Wang, Chang-Pan Liu, Wen-Sen Lee, Yao-Shen Chen, Fu-Der Wang, Shu-Hui Tseng, Chao-Nan Lin, Hung-Jen Tang, Yu-Hui Chen, Wang-Huei Sheng, Chun-Ming Lee, Ming-Huei Liao, Po-Ren Hsueh
  • Genomic Study of <em>bla</em><sub>IMI</sub>-Positive <span class="named-content genus-species" id="named-content-1">Enterobacter cloacae</span> Complex in Singapore over a Five-Year Study Period
    Epidemiology and Surveillance
    Genomic Study of blaIMI-Positive Enterobacter cloacae Complex in Singapore over a Five-Year Study Period

    The blaIMI gene is rarely detected outside the Enterobacter genus. Genomic characterization of 87 blaIMI-positive Enterobacter cloacae complex members revealed that the largest phylogenomic clade was made up of E. cloacae subsp. cloacae (71.3...

    Sophie Octavia, Tse Hsien Koh, Oon Tek Ng, Kalisvar Marimuthu, Indumathi Venkatachalam, Raymond T. P. Lin, Jeanette W. P. Teo
  • A Genotype-Phenotype Correlation Study of SHV β-Lactamases Offers New Insight into SHV Resistance Profiles
    Mechanisms of Resistance
    A Genotype-Phenotype Correlation Study of SHV β-Lactamases Offers New Insight into SHV Resistance Profiles

    The SHV β-lactamases (BLs) have undergone strong allele diversification that has changed their substrate specificities. Based on 147 NCBI entries for SHV alleles, in silico mathematical models predicted 5 positions as relevant for the β-lactamase inhibitor (BLI)-resistant (2br) phenotype, 12 positions as relevant for the extended-spectrum BL (ESBL) (2be) phenotype, and 2 positions as related solely to the narrow-spectrum (2b)...

    Svetlana Neubauer, Sara Madzgalla, Mike Marquet, Anne Klabunde, Bernd Büttner, Alexander Göhring, Christian Brandt, Karl-Heinz Feller, Mathias W. Pletz, Oliwia Makarewicz
  • Complex Response of the CpxAR Two-Component System to β-Lactams on Antibiotic Resistance and Envelope Homeostasis in <em>Enterobacteriaceae</em>
    Mechanisms of Resistance
    Complex Response of the CpxAR Two-Component System to β-Lactams on Antibiotic Resistance and Envelope Homeostasis in Enterobacteriaceae

    The Cpx stress response is widespread among Enterobacteriaceae. We previously reported a mutation in cpxA in a multidrug-resistant strain of Klebsiella aerogenes isolated from a patient treated with imipenem. This mutation yields a single-amino-acid substitution (Y144N) located in the periplasmic sensor domain of CpxA. In this work, we sought to...

    Muriel Masi, Elizabeth Pinet, Jean-Marie Pagès
  • Comparison of Commensal and Clinical Isolates for Diversity of Plasmids in <span class="named-content genus-species" id="named-content-1">Escherichia coli</span> and <span class="named-content genus-species" id="named-content-2">Klebsiella pneumoniae</span>
    Epidemiology and Surveillance
    Comparison of Commensal and Clinical Isolates for Diversity of Plasmids in Escherichia coli and Klebsiella pneumoniae

    In this study, the plasmid content of clinical and commensal strains was analyzed and compared. The replicon profile was similar in both populations, except for L, M, A/C, and N (detected only in clinical strains) and HI1 (only in commensal strains). Although I1 and F were the most frequent replicons, only IncI1, sequence type 12 (ST12) was associated with blaCMY-2 in both populations. In contrast, the widespread...

    Judith Rodríguez-Navarro, Elisenda Miró, Maryury Brown-Jaque, Juan Carlos Hurtado, Albert Moreno, Maite Muniesa, Juan José González-López, Jordi Vila, Paula Espinal, Ferran Navarro
  • A Pilot Study of Chicago Waterways as Reservoirs of Multidrug-Resistant <em>Enterobacteriaceae</em> (MDR-Ent) in a High-Risk Region for Community-Acquired MDR-Ent Infection in Children
    Epidemiology and Surveillance
    A Pilot Study of Chicago Waterways as Reservoirs of Multidrug-Resistant Enterobacteriaceae (MDR-Ent) in a High-Risk Region for Community-Acquired MDR-Ent Infection in Children

    Community-acquired multidrug resistant Enterobacteriaceae (MDR-Ent) infections continue to increase in the United States. In prior studies, we identified neighboring regions in Chicago, Illinois, where children have 5 to 6 times greater odds of MDR-Ent infections. To prevent community spread of MDR-Ent, we need to identify the MDR-Ent reservoirs. A pilot study of 4 Chicago waterways for MDR-Ent and associated antibiotic...

    Latania K. Logan, Liqing Zhang, Stefan J. Green, Samuel Dorevitch, Gustavo A. Arango-Argoty, Kendrick Reme, Emily Garner, Jared Aldstadt, Yvette J. Johnson-Walker, Mary K. Hayden, Robert A. Weinstein, Amy Pruden
  • Open Access
    Model-Informed Drug Development, Pharmacokinetic/Pharmacodynamic Cutoff Value Determination, and Antibacterial Efficacy of Benapenem against <em>Enterobacteriaceae</em>
    Experimental Therapeutics
    Model-Informed Drug Development, Pharmacokinetic/Pharmacodynamic Cutoff Value Determination, and Antibacterial Efficacy of Benapenem against Enterobacteriaceae

    Benapenem is a novel carbapenem. The objective of this study was to determine the pharmacokinetic (PK)/pharmacodynamic (PD) cutoff values and evaluate the optimal administration regimens of benapenem for the treatment of bacterial infections via PK/PD modeling and simulation. Ertapenem was used as a control. Infected mice received an intravenous (i.v.) injection of benapenem or ertapenem of 14.6, 58.4, or 233.6 mg/kg of body weight, and...

    Xi-wei Ji, Feng Xue, Zi-sheng Kang, Wei Zhong, Isabelle Hui-san Kuan, Xi-ping Yang, Xiao Zhu, Yun Li, Yuan Lv
  • Open Access
    Activity of Meropenem-Vaborbactam against Bacterial Isolates Causing Pneumonia in Patients in U.S. Hospitals during 2014 to 2018
    Epidemiology and Surveillance
    Activity of Meropenem-Vaborbactam against Bacterial Isolates Causing Pneumonia in Patients in U.S. Hospitals during 2014 to 2018

    Meropenem-vaborbactam is approved to treat hospital-acquired pneumonia (HAP), including ventilator-associated pneumonia (VAP), in Europe. Meropenem-vaborbactam activity was evaluated against 3,193 Pseudomonas aeruginosa and 4,790 Enterobacterales isolates causing pneumonia, including VAP, in hospitalized patients in the United States. Susceptibility testing...

    Cecilia G. Carvalhaes, Dee Shortridge, Helio S. Sader, Mariana Castanheira

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