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Enterococcus faecalis

  • Is Once-Daily High-Dose Ceftriaxone plus Ampicillin an Alternative for <span class="named-content genus-species" id="named-content-1">Enterococcus faecalis</span> Infective Endocarditis in Outpatient Parenteral Antibiotic Therapy Programs?
    Experimental Therapeutics
    Is Once-Daily High-Dose Ceftriaxone plus Ampicillin an Alternative for Enterococcus faecalis Infective Endocarditis in Outpatient Parenteral Antibiotic Therapy Programs?

    Ceftriaxone administered as once-daily high-dose short infusion combined with ampicillin has been proposed for the treatment of Enterococcus faecalis infective endocarditis in outpatient parenteral antibiotic therapy programs (OPAT). This combination requires synergistic activity, but the attainment of ceftriaxone synergic concentration (Cs) with the regimen proposed...

    Laura Herrera-Hidalgo, Arístides de Alarcón, Luis Eduardo López-Cortes, Rafael Luque-Márquez, Luis Fernando López-Cortes, Alicia Gutiérrez-Valencia, María Victoria Gil-Navarro
    and on behalf of Grupo para el Estudio de las Infecciones Cardiovasculares de la Sociedad Andaluza de Enfermedades Infecciosas
  • Comparative <em>In Vitro</em> Activities of Ceftaroline and Tedizolid against Clinical Strains of <span class="named-content genus-species" id="named-content-1">Staphylococcus aureus</span> and <em>Enterococcus</em>: Results from the China Antimicrobial Surveillance Network (CHINET) in 2018
    Susceptibility
    Comparative In Vitro Activities of Ceftaroline and Tedizolid against Clinical Strains of Staphylococcus aureus and Enterococcus: Results from the China Antimicrobial Surveillance Network (CHINET) in 2018

    The in vitro activities of ceftaroline and tedizolid were compared against Staphylococcus aureus, Enterococcus faecalis, and Enterococcus faecium clinical isolates collected from the China Antimicrobial Surveillance...

    Yan Guo, Yang Yang, Yonggui Zheng, Shi Wu, Dandan Yin, Demei Zhu, Fupin Hu
    and on behalf of China Antimicrobial Surveillance Network (CHINET) Study Group
  • Ampicillin and Ceftriaxone Solution Stability at Different Temperatures in Outpatient Parenteral Antimicrobial Therapy
    Clinical Therapeutics
    Ampicillin and Ceftriaxone Solution Stability at Different Temperatures in Outpatient Parenteral Antimicrobial Therapy

    The inclusion of ampicillin-containing regimens in outpatient parenteral antimicrobial therapy programs (OPAT) depends upon solution stability under conditions similar to those experienced in these programs. Lack of this information could hinder the inclusion in OPAT of patients suffering from Enterococcus faecalis infective endocarditis treated with ampicillin plus...

    L. Herrera-Hidalgo, L. E. López-Cortes, R. Luque-Márquez, J. Gálvez-Acebal, A. de Alarcón, L. F. López-Cortes, A. Gutiérrez-Valencia, M. V. Gil-Navarro
  • Transferable Resistance Gene <em>optrA</em> in <span class="named-content genus-species" id="named-content-1">Enterococcus faecalis</span> from Swine in Brazil
    Mechanisms of Resistance
    Transferable Resistance Gene optrA in Enterococcus faecalis from Swine in Brazil

    OptrA is an ATP-binding cassette (ABC)-F protein that confers resistance to oxazolidinones and phenicols and can be either plasmid-encoded or chromosomally encoded. Here, we isolated 13 Enterococcus faecalis strains possessing a linezolid MIC of ≥4 mg/liter from nursery pigs in swine herds located across Brazil. Genome sequence comparison showed that these strains...

    Lara M. Almeida, François Lebreton, Anthony Gaca, Paulo M. Bispo, Jose T. Saavedra, Rodrigo N. Calumby, Luciano M. Grillo, Ticiano G. Nascimento, Pedro H. Filsner, Andrea M. Moreno, Michael S. Gilmore
  • Outcomes of Patients with Bloodstream Infections Caused by Ampicillin-Susceptible but Penicillin-Resistant <span class="named-content genus-species" id="named-content-1">Enterococcus faecalis</span>: Caution in Interpreting the Results
    Letter to the Editor
    Outcomes of Patients with Bloodstream Infections Caused by Ampicillin-Susceptible but Penicillin-Resistant Enterococcus faecalis: Caution in Interpreting the Results
    Nicolo L. Cabrera, Alexandre E. Malek, Samuel L. Aitken, Cesar A. Arias
  • Assessment of Tedizolid <em>In Vitro</em> Activity and Resistance Mechanisms against a Collection of <em>Enterococcus</em> spp. Causing Invasive Infections, Including Isolates Requiring an Optimized Dosing Strategy for Daptomycin from U.S. and European Medical Centers, 2016 to 2018
    Epidemiology and Surveillance
    Assessment of Tedizolid In Vitro Activity and Resistance Mechanisms against a Collection of Enterococcus spp. Causing Invasive Infections, Including Isolates Requiring an Optimized Dosing Strategy for Daptomycin from U.S. and European Medical Centers, 2016 to 2018

    High-level aminoglycoside resistance was noted in 30.0% of Enterococcus faecalis and 25.2% of Enterococcus faecium isolates. Only 3.3% and 2.1% of E. faecalis isolates had elevated daptomycin MIC (≥2 mg/liter) and vancomycin...

    Cecilia G. Carvalhaes, Helio S. Sader, Robert K. Flamm, Jennifer M. Streit, Rodrigo E. Mendes
  • Open Access
    Omadacycline Efficacy against <span class="named-content genus-species" id="named-content-1">Enterococcus faecalis</span> Isolated in China: <em>In Vitro</em> Activity, Heteroresistance, and Resistance Mechanisms
    Editor's Pick Mechanisms of Resistance
    Omadacycline Efficacy against Enterococcus faecalis Isolated in China: In Vitro Activity, Heteroresistance, and Resistance Mechanisms

    This study aimed to evaluate the in vitro antimicrobial activity, heteroresistance emergence, and resistance mechanism of omadacycline (OMC) in clinical Enterococcus faecalis isolates from China. A total of 276 isolates were collected retrospectively in China from 2011 to 2015. The MICs of OMC, doxycycline (DOX), and minocycline (MIN) against...

    Zhiwei Lin, Zhangya Pu, Guangjian Xu, Bing Bai, Zhong Chen, Xiang Sun, Jinxin Zheng, Peiyu Li, Di Qu, Qiwen Deng, Zhijian Yu
  • Some Doubts on the Study of Clinical Prognoses of Patients with a Bloodstream Infection Caused by Ampicillin-Susceptible but Penicillin-Resistant <span class="named-content genus-species" id="named-content-1">Enterococcus faecalis</span>
    Letter to the Editor
    Some Doubts on the Study of Clinical Prognoses of Patients with a Bloodstream Infection Caused by Ampicillin-Susceptible but Penicillin-Resistant Enterococcus faecalis
    Xianshi Zhou, Guanghua Tang
  • Conjugative Delivery of CRISPR-Cas9 for the Selective Depletion of Antibiotic-Resistant Enterococci
    Editor's Pick Mechanisms of Resistance
    Conjugative Delivery of CRISPR-Cas9 for the Selective Depletion of Antibiotic-Resistant Enterococci

    The innovation of new therapies to combat multidrug-resistant (MDR) bacteria is being outpaced by the continued rise of MDR bacterial infections. Of particular concern are hospital-acquired infections (HAIs) that are recalcitrant to antibiotic therapies. The Gram-positive intestinal pathobiont Enterococcus faecalis is associated with HAIs, and some strains are MDR....

    Marinelle Rodrigues, Sara W. McBride, Karthik Hullahalli, Kelli L. Palmer, Breck A. Duerkop
  • Tn<em>6674</em> Is a Novel Enterococcal <em>optrA</em>-Carrying Multiresistance Transposon of the Tn<em>554</em> Family
    Mechanisms of Resistance
    Tn6674 Is a Novel Enterococcal optrA-Carrying Multiresistance Transposon of the Tn554 Family

    The novel 12,932-bp nonconjugative multiresistance transposon Tn6674 was identified in the chromosomal DNA of a porcine Enterococcus faecalis strain. Tn6674 belongs to the Tn554 family of transposons. It shares the same arrangement of the transposase genes tnpA, tnpB, and tnpC with Tn554. However, in...

    Dexi Li, Xing-Yun Li, Stefan Schwarz, Mengyan Yang, Su-Mei Zhang, Wenbo Hao, Xiang-Dang Du

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