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Enzyme Inhibitors

  • Susceptibility
    Novel Cell-Killing Mechanisms of Hydroxyurea and the Implication toward Combination Therapy for the Treatment of Fungal Infections
    Amanpreet Singh, Ameeta Agarwal, Yong-jie Xu
  • Experimental Therapeutics
    Development of Methionyl-tRNA Synthetase Inhibitors as Antibiotics for Gram-Positive Bacterial Infections
    Omeed Faghih, Zhongsheng Zhang, Ranae M. Ranade, J. Robert Gillespie, Sharon A. Creason, Wenlin Huang, Sayaka Shibata, Ximena Barros-Álvarez, Christophe L. M. J. Verlinde, Wim G. J. Hol, Erkang Fan, Frederick S. Buckner
  • Open Access
    Antiviral Agents
    Original Chemical Series of Pyrimidine Biosynthesis Inhibitors That Boost the Antiviral Interferon Response
    Marianne Lucas-Hourani, Daniel Dauzonne, Hélène Munier-Lehmann, Samira Khiar, Sébastien Nisole, Julien Dairou, Olivier Helynck, Philippe V. Afonso, Frédéric Tangy, Pierre-Olivier Vidalain
  • Clinical Therapeutics
    Coadministration of Allopurinol To Increase Antimycobacterial Efficacy of Pyrazinamide as Evaluated in a Whole-Blood Bactericidal Activity Model
    Claire M. Naftalin, Rupangi Verma, Meera Gurumurthy, Qingshu Lu, Matthew Zimmerman, Benjamin Chaik Meng Yeo, Kin Hup Tan, Wenwei Lin, Buduo Yu, Véronique Dartois, Nicholas I. Paton
  • Antiviral Agents
    The PA Endonuclease Inhibitor RO-7 Protects Mice from Lethal Challenge with Influenza A or B Viruses
    Jeremy C. Jones, Bindumadhav M. Marathe, Peter Vogel, Rodolfo Gasser, Isabel Najera, Elena A. Govorkova
  • Mechanisms of Action: Physiological Effects
    Furanyl-Rhodanines Are Unattractive Drug Candidates for Development as Inhibitors of Bacterial RNA Polymerase
    Katherine R. Mariner, Rachel Trowbridge, Anil K. Agarwal, Keith Miller, Alex J. O'Neill, Colin W. G. Fishwick, Ian Chopra
  • Susceptibility
    Inhibition of Antibiotic-Resistant Staphylococcus aureus by the Broad-Spectrum Dihydrofolate Reductase Inhibitor RAB1
    C. R. Bourne, E. W. Barrow, R. A. Bunce, P. C. Bourne, K. D. Berlin, W. W. Barrow
  • Antiviral Agents
    Structure-Activity Analysis of Vinylogous Urea Inhibitors of Human Immunodeficiency Virus-Encoded Ribonuclease H
    Suhman Chung, Michaela Wendeler, Jason W. Rausch, Greg Beilhartz, Matthias Gotte, Barry R. O'Keefe, Alun Bermingham, John A. Beutler, Shixin Liu, Xiaowei Zhuang, Stuart F. J. Le Grice
  • Susceptibility
    In Vitro Potentiation of Carbapenems with ME1071, a Novel Metallo-β-Lactamase Inhibitor, against Metallo-β-Lactamase- Producing Pseudomonas aeruginosa Clinical Isolates
    Yoshikazu Ishii, Maki Eto, Yoko Mano, Kazuhiro Tateda, Keizo Yamaguchi
  • Susceptibility
    Chemical Validation of Phosphodiesterase C as a Chemotherapeutic Target in Trypanosoma cruzi, the Etiological Agent of Chagas' Disease
    Sharon King-Keller, Minyong Li, Alyssa Smith, Shilong Zheng, Gurpreet Kaur, Xiaochuan Yang, Binghe Wang, Roberto Docampo

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