Enzyme Inhibitors

Experimental Therapeutics
Development of Methionyl-tRNA Synthetase Inhibitors as Antibiotics for Gram-Positive Bacterial Infections
Omeed Faghih, Zhongsheng Zhang, Ranae M. Ranade, J. Robert Gillespie, Sharon A. Creason, Wenlin Huang, Sayaka Shibata, Ximena Barros-Álvarez, Christophe L. M. J. Verlinde, Wim G. J. Hol, Erkang Fan, Frederick S. Buckner
Susceptibility
Novel Cell-Killing Mechanisms of Hydroxyurea and the Implication toward Combination Therapy for the Treatment of Fungal Infections
Amanpreet Singh, Ameeta Agarwal, Yong-jie Xu
Open Access

Antiviral Agents
Original Chemical Series of Pyrimidine Biosynthesis Inhibitors That Boost the Antiviral Interferon Response
Marianne Lucas-Hourani, Daniel Dauzonne, Hélène Munier-Lehmann, Samira Khiar, Sébastien Nisole, Julien Dairou, Olivier Helynck, Philippe V. Afonso, Frédéric Tangy, Pierre-Olivier Vidalain
Clinical Therapeutics
Coadministration of Allopurinol To Increase Antimycobacterial Efficacy of Pyrazinamide as Evaluated in a Whole-Blood Bactericidal Activity Model
Claire M. Naftalin, Rupangi Verma, Meera Gurumurthy, Qingshu Lu, Matthew Zimmerman, Benjamin Chaik Meng Yeo, Kin Hup Tan, Wenwei Lin, Buduo Yu, Véronique Dartois, Nicholas I. Paton
Antiviral Agents
The PA Endonuclease Inhibitor RO-7 Protects Mice from Lethal Challenge with Influenza A or B Viruses
Jeremy C. Jones, Bindumadhav M. Marathe, Peter Vogel, Rodolfo Gasser, Isabel Najera, Elena A. Govorkova
Mechanisms of Action: Physiological Effects
Furanyl-Rhodanines Are Unattractive Drug Candidates for Development as Inhibitors of Bacterial RNA Polymerase
Katherine R. Mariner, Rachel Trowbridge, Anil K. Agarwal, Keith Miller, Alex J. O'Neill, Colin W. G. Fishwick, Ian Chopra
Susceptibility
Inhibition of Antibiotic-Resistant Staphylococcus aureus by the Broad-Spectrum Dihydrofolate Reductase Inhibitor RAB1
C. R. Bourne, E. W. Barrow, R. A. Bunce, P. C. Bourne, K. D. Berlin, W. W. Barrow
Antiviral Agents
Structure-Activity Analysis of Vinylogous Urea Inhibitors of Human Immunodeficiency Virus-Encoded Ribonuclease H
Suhman Chung, Michaela Wendeler, Jason W. Rausch, Greg Beilhartz, Matthias Gotte, Barry R. O'Keefe, Alun Bermingham, John A. Beutler, Shixin Liu, Xiaowei Zhuang, Stuart F. J. Le Grice
Susceptibility
In Vitro Potentiation of Carbapenems with ME1071, a Novel Metallo-β-Lactamase Inhibitor, against Metallo-β-Lactamase- Producing Pseudomonas aeruginosa Clinical Isolates
Yoshikazu Ishii, Maki Eto, Yoko Mano, Kazuhiro Tateda, Keizo Yamaguchi
Susceptibility
Chemical Validation of Phosphodiesterase C as a Chemotherapeutic Target in Trypanosoma cruzi, the Etiological Agent of Chagas' Disease
Sharon King-Keller, Minyong Li, Alyssa Smith, Shilong Zheng, Gurpreet Kaur, Xiaochuan Yang, Binghe Wang, Roberto Docampo

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Enzyme Inhibitors

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