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epidemiology

  • Correlation of <em>Trichosporon asahii</em> Genotypes with Anatomical Sites and Antifungal Susceptibility Profiles: Data Analyses from 284 Isolates Collected in the Last 22 Years across 24 Medical Centers
    Editor's Pick Susceptibility
    Correlation of Trichosporon asahii Genotypes with Anatomical Sites and Antifungal Susceptibility Profiles: Data Analyses from 284 Isolates Collected in the Last 22 Years across 24 Medical Centers

    Trichosporon asahii is an opportunistic fungal pathogen that can cause severe infections with high mortality rates. Azole derivatives are the best-targeted therapy for T. asahii invasive infections, but azole-resistant isolates have been reported.

    Elaine Cristina Francisco, João N. de Almeida Junior, Flávio Queiroz-Telles, Valério Rodrigues Aquino, Ana Verena A. Mendes, Marcio de Oliveira Silva, Paulo de Tarso O. e Castro, Thais Guimarães, Vinicius Ponzio, Rosane C. Hahn, Guilherme M. Chaves, Arnaldo L. Colombo
  • Open Access
    Prolonged Outbreak of Multidrug-Resistant <span class="named-content genus-species" id="named-content-1">Shigella sonnei</span> Harboring <em>bla</em><sub>CTX-M-27</sub> in Victoria, Australia
    Epidemiology and Surveillance
    Prolonged Outbreak of Multidrug-Resistant Shigella sonnei Harboring blaCTX-M-27 in Victoria, Australia

    In Australia, cases of shigellosis usually occur in returned travelers from regions of shigellosis endemicity or in men who have sex with men. Resistance to multiple antibiotics has significantly increased in Shigella sonnei isolates and represents a significant public health concern. We investigate an outbreak of multidrug-resistant...

    Danielle J. Ingle, Patiyan Andersson, Mary Valcanis, Jessica Barnden, Anders Gonçalves da Silva, Kristy A. Horan, Torsten Seemann, Marion Easton, Deborah A. Williamson, Norelle L. Sherry, Benjamin P. Howden
  • Chromosomal and Plasmid-Borne Tigecycline Resistance Genes <em>tet</em>(X3) and <em>tet</em>(X4) in Dairy Cows on a Chinese Farm
    Epidemiology and Surveillance
    Chromosomal and Plasmid-Borne Tigecycline Resistance Genes tet(X3) and tet(X4) in Dairy Cows on a Chinese Farm

    We isolated 47 Acinetobacter strains carrying tet(X3) and 4 ST767 E. coli strains carrying tet(X4) from 296 rectal swab samples from dairy cows on a Chinese farm. tet(X3) was located on chromosomes or diverse plasmids, and tet(X4) was located on IncFIBκ/FIA(HI1)/...

    Rong Zhang, Ning Dong, Yu Zeng, Zhangqi Shen, Jiayue Lu, Congcong Liu, Zhuo-an Huang, Qiaoling Sun, Qipeng Cheng, Lingbin Shu, Jiachang Cai, Edward Waichi Chan, Dejun Liu, Gongxiang Chen, Yang Wang, Sheng Chen
  • Antimicrobial Susceptibilities of <span class="named-content genus-species" id="named-content-1">Clostridium difficile</span> Isolates from 12 Asia-Pacific Countries in 2014 and 2015
    Susceptibility
    Antimicrobial Susceptibilities of Clostridium difficile Isolates from 12 Asia-Pacific Countries in 2014 and 2015

    Clostridium (Clostridioides) difficile causes toxin-mediated diarrhea and pseudomembranous colitis, primarily among hospital inpatients. Outbreaks of C. difficile infection (CDI) have been caused by strains with acquired antimicrobial resistance, particularly fluoroquinolone resistance, including...

    Tanya Lew, Papanin Putsathit, Kyung Mok Sohn, Yuan Wu, Kentaro Ouchi, Yoshikazu Ishii, Kazuhiro Tateda, Thomas V. Riley, Deirdre A. Collins
    and for the Clostridium difficile Asia Pacific (CDAP) Study Group
  • Methicillin-Resistant <span class="named-content genus-species" id="named-content-1">Staphylococcus aureus</span> (MRSA) Nasal Screening: Clinical Use for Excluding Diabetic Foot Infection with MRSA
    Letter to the Editor
    Methicillin-Resistant Staphylococcus aureus (MRSA) Nasal Screening: Clinical Use for Excluding Diabetic Foot Infection with MRSA
    Maroun M. Sfeir
  • Retrospective Analysis of Antimicrobial Susceptibility Profiles of <em>Nocardia</em> Species from a Tertiary Hospital and Reference Laboratory, 2011 to 2017
    Susceptibility
    Retrospective Analysis of Antimicrobial Susceptibility Profiles of Nocardia Species from a Tertiary Hospital and Reference Laboratory, 2011 to 2017

    Nocardia species are found worldwide and are opportunistic pathogens of both immunocompromised and immunocompetent hosts. Recent updates to the taxonomy of this genus have indicated that there are more than 90 recognized species of Nocardia with 54 species reported to be clinically relevant.

    Ahmed M. Hamdi, Madiha Fida, Sharon M. Deml, Omar M. Abu Saleh, Nancy L. Wengenack
  • Carbapenem-Resistant Gram-Negative Bacterial Infections in Children
    Minireview
    Carbapenem-Resistant Gram-Negative Bacterial Infections in Children

    Carbapenem-resistant organisms (CRO) are a major global public health threat. Enterobacterales hydrolyze almost all β-lactams through carbapenemase production. Infections caused by CRO are challenging to treat due to the limited number of antimicrobial options. This leads to significant morbidity and mortality. Over the last few years, several new antibiotics effective against CRO have been approved.

    David Aguilera-Alonso, Luis Escosa-García, Jesús Saavedra-Lozano, Emilia Cercenado, Fernando Baquero-Artigao
  • Epidemiological Trends of Fungemia in Greece with a Focus on Candidemia during the Recent Financial Crisis: a 10-Year Survey in a Tertiary Care Academic Hospital and Review of Literature
    Susceptibility
    Epidemiological Trends of Fungemia in Greece with a Focus on Candidemia during the Recent Financial Crisis: a 10-Year Survey in a Tertiary Care Academic Hospital and Review of Literature

    Updated information on the epidemiology of candidemia, particularly during severe socioeconomic events, is important for proper management of these infections.

    Maria Siopi, Aikaterini Tarpatzi, Eleni Kalogeropoulou, Sofia Damianidou, Alexandra Vasilakopoulou, Sophia Vourli, Spyros Pournaras, Joseph Meletiadis
  • Whole-Genome Sequencing To Identify Drivers of Carbapenem-Resistant <span class="named-content genus-species" id="named-content-1">Klebsiella pneumoniae</span> Transmission within and between Regional Long-Term Acute-Care Hospitals
    Editor's Pick Epidemiology and Surveillance
    Whole-Genome Sequencing To Identify Drivers of Carbapenem-Resistant Klebsiella pneumoniae Transmission within and between Regional Long-Term Acute-Care Hospitals

    Carbapenem-resistant Klebsiella pneumoniae (CRKP) is an antibiotic resistance threat of the highest priority. Given the limited treatment options for this multidrug-resistant organism (MDRO), there is an urgent need for targeted strategies to prevent transmission.

    Jennifer H. Han, Zena Lapp, Frederic Bushman, Ebbing Lautenbach, Ellie J. C. Goldstein, Lisa Mattei, Casey E. Hofstaedter, Dorothy Kim, Irving Nachamkin, Charles Garrigan, Tanya Jain, Warren Bilker, Hannah M. Wolford, Rachel B. Slayton, Jacqueleen Wise, Pam Tolomeo, Evan S. Snitkin
  • Open Access
    Trends and Risk Factors for Antimicrobial-Resistant <em>Neisseria gonorrhoeae</em>, Melbourne, Australia, 2007 to 2018
    Editor's Pick Epidemiology and Surveillance
    Trends and Risk Factors for Antimicrobial-Resistant Neisseria gonorrhoeae, Melbourne, Australia, 2007 to 2018

    Antimicrobial resistance (AMR) in Neisseria gonorrhoeae is a major public health problem. Traditionally, AMR surveillance programs for N. gonorrhoeae have focused mainly on laboratory data to describe the prevalence and trends of resistance. However, integrating individual-level risk factors (e.g.,...

    Deborah A. Williamson, Christopher K. Fairley, Benjamin P. Howden, Marcus Y. Chen, Kerrie Stevens, Vesna De Petra, Ian Denham, Eric P. F. Chow

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