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epithelial lining fluid

  • Pharmacokinetics and Penetration of Sitafloxacin into Alveolar Epithelial Lining Fluid in Critically Ill Thai Patients with Pneumonia
    Pharmacology
    Pharmacokinetics and Penetration of Sitafloxacin into Alveolar Epithelial Lining Fluid in Critically Ill Thai Patients with Pneumonia

    Sitafloxacin showed potent activity against various respiratory pathogens. Blood and bronchoalveolar lavage (BAL) fluid samples were obtained from 12 subjects after a single oral dose of sitafloxacin 200 mg. The mean ± SD (median) maximum ratio of epithelial lining fluid (ELF) to unbound plasma concentration was 1.02 ± 0.58 (1.33).

    Taniya Paiboonvong, Wichit Nosoongnoen, Korbtham Sathirakul, Viratch Tangsujaritvijit, Jaipak Kaemapairoj, Pramote Tragulpiankit, Preecha Montakantikul
  • Plasma and Intrapulmonary Concentrations of ETX2514 and Sulbactam following Intravenous Administration of ETX2514SUL to Healthy Adult Subjects
    Pharmacology
    Plasma and Intrapulmonary Concentrations of ETX2514 and Sulbactam following Intravenous Administration of ETX2514SUL to Healthy Adult Subjects

    ETX2514 is a novel β-lactamase inhibitor that broadly inhibits Ambler class A, C, and D β-lactamases. ETX2514 combined with sulbactam (SUL) in vitro restores sulbactam activity against Acinetobacter baumannii.

    Keith A. Rodvold, Mark H. Gotfried, Robin D. Isaacs, John P. O'Donnell, Emily Stone
  • Meropenem Combined with Ciprofloxacin Combats Hypermutable <span class="named-content genus-species" id="named-content-1">Pseudomonas aeruginosa</span> from Respiratory Infections of Cystic Fibrosis Patients
    Pharmacology
    Meropenem Combined with Ciprofloxacin Combats Hypermutable Pseudomonas aeruginosa from Respiratory Infections of Cystic Fibrosis Patients

    Hypermutable Pseudomonas aeruginosa organisms are prevalent in chronic respiratory infections and have been associated with reduced lung function in cystic fibrosis (CF); these isolates can become resistant to all antibiotics in monotherapy. This study aimed to evaluate the time course of bacterial killing and resistance of meropenem and ciprofloxacin in combination...

    Vanessa E. Rees, Rajbharan Yadav, Kate E. Rogers, Jürgen B. Bulitta, Veronika Wirth, Antonio Oliver, John D. Boyce, Anton Y. Peleg, Roger L. Nation, Cornelia B. Landersdorfer
  • Pharmacology
    Plasma and Intrapulmonary Concentrations of Cefepime and Zidebactam following Intravenous Administration of WCK 5222 to Healthy Adult Subjects

    WCK 5222 is a combination of cefepime and the novel β-lactam enhancer zidebactam being developed for the treatment of serious Gram-negative bacterial infections. The objective of this study was to compare plasma (total), epithelial lining fluid (ELF), and alveolar macrophage (AM) concentrations of cefepime and zidebactam in healthy adult subjects.

    Keith A. Rodvold, Mark H. Gotfried, Rakesh Chugh, Mugdha Gupta, Anasuya Patel, Rajesh Chavan, Ravindra Yeole, H. David Friedland, Ashima Bhatia
  • Pharmacology
    Intrapulmonary Pharmacokinetics of Levonadifloxacin following Oral Administration of Alalevonadifloxacin to Healthy Adult Subjects
    Keith A. Rodvold, Mark H. Gotfried, Rakesh Chugh, Mugdha Gupta, Ravindra Yeole, Anasuya Patel, Ashima Bhatia
  • Pharmacology
    Comparison of Plasma and Intrapulmonary Concentrations of Nafithromycin (WCK 4873) in Healthy Adult Subjects
    Keith A. Rodvold, Mark H. Gotfried, Rakesh Chugh, Mugdha Gupta, H. David Friedland, Ashima Bhatia
  • Open Access
    Pharmacology
    Comparison of Omadacycline and Tigecycline Pharmacokinetics in the Plasma, Epithelial Lining Fluid, and Alveolar Cells of Healthy Adult Subjects
    Mark H. Gotfried, Karolyn Horn, Lynne Garrity-Ryan, Stephen Villano, Evan Tzanis, Surya Chitra, Amy Manley, S. Ken Tanaka, Keith A. Rodvold
  • Experimental Therapeutics
    Comparative Pharmacodynamics of Telavancin and Vancomycin in the Neutropenic Murine Thigh and Lung Infection Models against Staphylococcus aureus
    Alexander J. Lepak, Miao Zhao, David R. Andes
  • Pharmacology
    Penetration of Ciprofloxacin and Amikacin into the Alveolar Epithelial Lining Fluid of Rats with Pulmonary Fibrosis
    Wentao Ni, Deqing Yang, Hekun Mei, Jin Zhao, Beibei Liang, Nan Bai, Dong Chai, Junchang Cui, Rui Wang, Youning Liu
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