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ergosterol

  • The C<sub>2</sub>H<sub>2</sub> Transcription Factor SltA Contributes to Azole Resistance by Coregulating the Expression of the Drug Target Erg11A and the Drug Efflux Pump Mdr1 in <span class="named-content genus-species" id="named-content-1">Aspergillus fumigatus</span>
    Mechanisms of Resistance
    The C2H2 Transcription Factor SltA Contributes to Azole Resistance by Coregulating the Expression of the Drug Target Erg11A and the Drug Efflux Pump Mdr1 in Aspergillus fumigatus

    The emergence of azole-resistant fungal pathogens has posed a great threat to public health worldwide. Although the molecular mechanism of azole resistance has been extensively investigated, the potential regulators of azole resistance remain largely unexplored.

    Wenlong Du, Pengfei Zhai, Tingli Wang, Michael J. Bromley, Yuanwei Zhang, Ling Lu
  • <em>ERG11</em> Polymorphism in Voriconazole-Resistant <span class="named-content genus-species" id="named-content-1">Candida tropicalis</span>: Weak Role of <em>ERG11</em> Expression, Ergosterol Content, and Membrane Permeability
    Mechanisms of Resistance
    ERG11 Polymorphism in Voriconazole-Resistant Candida tropicalis: Weak Role of ERG11 Expression, Ergosterol Content, and Membrane Permeability

    Mutations in ERG11 were detected by gene sequencing and amino acid alignment in 18 Candida tropicalis strains with different degrees of sensitivity to voriconazole (VRC). ERG11 expression, sterol content, and membrane permeability were also evaluated. We report three missense mutations in ERG11 that resulted in resistance to VRC. The...

    Patricia Navarro-Rodríguez, Loida López-Fernández, Adela Martin-Vicente, Josep Guarro, Javier Capilla
  • Open Access
    <span class="named-content genus-species" id="named-content-1">Candida glabrata</span> Transcription Factor Rpn4 Mediates Fluconazole Resistance through Regulation of Ergosterol Biosynthesis and Plasma Membrane Permeability
    Mechanisms of Resistance
    Candida glabrata Transcription Factor Rpn4 Mediates Fluconazole Resistance through Regulation of Ergosterol Biosynthesis and Plasma Membrane Permeability

    The ability to acquire azole resistance is an emblematic trait of the fungal pathogen Candida glabrata. Understanding the molecular basis of azole resistance in this pathogen is crucial for designing more suitable therapeutic strategies. This study shows that the C. glabrata transcription factor (TF...

    Pedro Pais, Raquel Califórnia, Mónica Galocha, Romeu Viana, Mihaela Ola, Mafalda Cavalheiro, Azusa Takahashi-Nakaguchi, Hiroji Chibana, Geraldine Butler, Miguel C. Teixeira
  • Mechanisms of Action: Physiological Effects
    Miltefosine Has a Postantifungal Effect and Induces Apoptosis in Cryptococcus Yeasts

    Cryptococcus spp. are common opportunistic fungal pathogens, particularly in HIV patients.

    Cristina de Castro Spadari, Taissa Vila, Sonia Rozental, Kelly Ishida
  • Mechanisms of Resistance
    Loss of C-5 Sterol Desaturase Activity Results in Increased Resistance to Azole and Echinocandin Antifungals in a Clinical Isolate of Candida parapsilosis
    Jeffrey M. Rybak, C. Michael Dickens, Josie E. Parker, Kelly E. Caudle, Kayihura Manigaba, Sarah G. Whaley, Andrew T. Nishimoto, Arturo Luna-Tapia, Sujoy Roy, Qing Zhang, Katherine S. Barker, Glen E. Palmer, Thomas R. Sutter, Ramin Homayouni, Nathan P. Wiederhold, Steven L. Kelly, P. David Rogers
  • Mechanisms of Action: Physiological Effects
    Natamycin Inhibits Vacuole Fusion at the Priming Phase via a Specific Interaction with Ergosterol
    Yvonne Maria te Welscher, Lynden Jones, Martin Richard van Leeuwen, Jan Dijksterhuis, Ben de Kruijff, Gary Eitzen, Eefjan Breukink
  • Mechanisms of Resistance
    Multidrug Transporters CaCdr1p and CaMdr1p of Candida albicans Display Different Lipid Specificities: both Ergosterol and Sphingolipids Are Essential for Targeting of CaCdr1p to Membrane Rafts
    Ritu Pasrija, Sneh Lata Panwar, Rajendra Prasad
  • Mechanisms of Action: Physiological Effects
    Targeting the Calcineurin Pathway Enhances Ergosterol Biosynthesis Inhibitors against Trichophyton mentagrophytes In Vitro and in a Human Skin Infection Model
    Chiatogu Onyewu, Emily Eads, Wiley A. Schell, John R. Perfect, Yehuda Ullmann, Gil Kaufman, Benjamin A. Horwitz, Israela Berdicevsky, Joseph Heitman
  • Mechanisms of Resistance
    A Small Subpopulation of Blastospores in Candida albicans Biofilms Exhibit Resistance to Amphotericin B Associated with Differential Regulation of Ergosterol and β-1,6-Glucan Pathway Genes
    Prasanna D. Khot, Peter A. Suci, R. Lance Miller, Raoul D. Nelson, Bonnie J. Tyler
  • Mechanisms of Resistance
    Candida albicans Zinc Cluster Protein Upc2p Confers Resistance to Antifungal Drugs and Is an Activator of Ergosterol Biosynthetic Genes
    Sarah MacPherson, Bassel Akache, Sandra Weber, Xavier De Deken, Martine Raymond, Bernard Turcotte

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