fitness
Mechanisms of ResistanceCreC Sensor Kinase Activation Enhances Growth of Escherichia coli in the Presence of Cephalosporins and CarbapenemsMutants with enhanced growth in the presence of an antibiotic are more difficult to identify than mutants where the antibiotic’s MIC increases, because they are not amenable to lethal selection in vitro. We report that activatory mutations in the CreC signal sensor enhance growth of Escherichia coli in the presence of cefoxitin, cefotaxime, and meropenem,...
Antiviral AgentsAn Evolutionary Model-Based Approach To Quantify the Genetic Barrier to Drug Resistance in Fast-Evolving Viruses and Its Application to HIV-1 Subtypes and Integrase InhibitorsViral pathogens causing global disease burdens are often characterized by high rates of evolutionary changes. The extensive viral diversity at baseline can shorten the time to escape from therapeutic or immune selective pressure and alter mutational pathways. The impact of genotypic background on the barrier to resistance can be difficult to capture, particularly for agents in experimental stages or that are recently approved or...
- Mechanisms of ResistanceIn Vitro Isolation and Characterization of Oxazolidinone-Resistant Mycobacterium tuberculosis