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Fusarium

  • <em>In Vitro</em> and <em>In Vivo</em> Study on the Synergistic Effect of Minocycline and Azoles against Pathogenic Fungi
    Susceptibility
    In Vitro and In Vivo Study on the Synergistic Effect of Minocycline and Azoles against Pathogenic Fungi

    In vitro and in vivo interactions of minocycline and azoles, including itraconazole, voriconazole, and posaconazole, against filamentous pathogenic fungi were investigated. A total of 56 clinical isolates were studied in vitro via broth microdilution checkerboard technique, including 20 strains of Aspergillus fumigatus, 7 strains of...

    Lujuan Gao, Yi Sun, Mingzhu Yuan, Ming Li, Tongxiang Zeng
  • Open Access
    Fosmanogepix (APX001) Is Effective in the Treatment of Immunocompromised Mice Infected with Invasive Pulmonary Scedosporiosis or Disseminated Fusariosis
    Editor's Pick Experimental Therapeutics
    Fosmanogepix (APX001) Is Effective in the Treatment of Immunocompromised Mice Infected with Invasive Pulmonary Scedosporiosis or Disseminated Fusariosis

    There are limited treatment options for immunosuppressed patients with lethal invasive fungal infections due to Fusarium and Scedosporium. Manogepix (MGX; APX001A) is a novel antifungal that targets the conserved Gwt1 enzyme required for localization of glycosylphosphatidylinositol-anchored mannoproteins in fungi. We evaluated the in vitro activity of MGX and the efficacy of the prodrug fosmanogepix (APX001)...

    Sondus Alkhazraji, Teclegiorgis Gebremariam, Abdullah Alqarihi, Yiyou Gu, Zeinab Mamouei, Shakti Singh, Nathan P. Wiederhold, Karen J. Shaw, Ashraf S. Ibrahim
  • <em>In Vitro</em> Susceptibility of <em>Fusarium</em> to Isavuconazole
    Susceptibility
    In Vitro Susceptibility of Fusarium to Isavuconazole

    To evaluate the in vitro susceptibility of Fusarium to isavuconazole, 75 clinical isolates were identified using matrix-assisted laser desorption ionization–time of flight mass spectrometry and then tested with a broth microdilution method (EUCAST) and the gradient concentration strip (GCS) technique. The activity of isavuconazole overall was shown to be limited, with an MIC50 of >16 μg/ml, without...

    A. Broutin, J. Bigot, Y. Senghor, A. Moreno-Sabater, J. Guitard, C. Hennequin
  • Therapeutic Challenges of Non-<em>Aspergillus</em> Invasive Mold Infections in Immunosuppressed Patients
    Editor's Pick Minireview
    Therapeutic Challenges of Non-Aspergillus Invasive Mold Infections in Immunosuppressed Patients

    While Aspergillus spp. remain the major cause of invasive mold infections in hematologic cancer patients and transplant recipients, other opportunistic molds, such as Mucorales, Fusarium, and Scedosporium spp. are increasingly encountered in an expanding population of patients with severe and prolonged immunosuppression. High potential for tissue invasion and dissemination, resistance to multiple...

    Frederic Lamoth, Dimitrios P. Kontoyiannis
  • Open Access
    <em>In Vitro</em> Activity of Chlorhexidine Compared with Seven Antifungal Agents against 98 <em>Fusarium</em> Isolates Recovered from Fungal Keratitis Patients
    Susceptibility
    In Vitro Activity of Chlorhexidine Compared with Seven Antifungal Agents against 98 Fusarium Isolates Recovered from Fungal Keratitis Patients

    Fungal keratitis is a common but severe eye infection in tropical and subtropical areas of the world. In regions with a temperate climate, the frequency of infection is rising in patients with contact lenses and following trauma. Early and adequate therapy is important to prevent disease progression and loss of vision. The management of Fusarium keratitis is complex, and the optimal treatment is not well defined.

    ...
    Claudy Oliveira dos Santos, Eva Kolwijck, Henrich A. van der Lee, Marlou C. Tehupeiory-Kooreman, Abdullah M. S. Al-Hatmi, Einoti Matayan, Matthew J. Burton, Cathrien A. Eggink, Paul E. Verweij
  • Natamycin and Voriconazole Exhibit Synergistic Interactions with Nonantifungal Ophthalmic Agents against <em>Fusarium</em> Species Ocular Isolates
    Susceptibility
    Natamycin and Voriconazole Exhibit Synergistic Interactions with Nonantifungal Ophthalmic Agents against Fusarium Species Ocular Isolates

    The in vitro activities of two antifungal drugs in combination with four nonantifungal ophthalmic agents were evaluated using a broth microdilution method and a collection of eight Fusarium ocular isolates that exhibited resistance to both natamycin (MICs, 14 to 32 μg/ml) and voriconazole (MICs, 4 to >128 μg/ml). Synergistic and indifferent interactions were observed for natamycin and 5-fluorouracil and natamycin...

    Christiaan A. Rees, Ruina Bao, Michael E. Zegans, Robert A. Cramer
  • Susceptibility
    Molecular Identification and Susceptibility Testing of Molds Isolated in a Prospective Surveillance of Triazole Resistance in Spain (FILPOP2 Study)

    Antifungal resistance is increasing by the emergence of intrinsically resistant species and by the development of secondary resistance in susceptible species. A previous study performed in Spain revealed levels of azole resistance in molds of between 10 and 12.7%, but secondary resistance in Aspergillus fumigatus was not detected.

    Ana Alastruey-Izquierdo, Laura Alcazar-Fuoli, Olga Rivero-Menéndez, Josefina Ayats, Carmen Castro, Julio García-Rodríguez, Lidia Goterris-Bonet, Elisa Ibáñez-Martínez, María José Linares-Sicilia, M. Teresa Martin-Gomez, Estrella Martín-Mazuelos, Teresa Pelaez, Javier Peman, Antonio Rezusta, Susana Rojo, Rocio Tejero, Diego Vicente Anza, Jesús Viñuelas, Maria Soledad Zapico, Manuel Cuenca-Estrella
    and on behalf of the FILPOP2 Project from GEMICOMED (SEIMC) and REIPI
  • Susceptibility
    EUCAST Determination of Olorofim (F901318) Susceptibility of Mold Species, Method Validation, and MICs
    Karin Meinike Jørgensen, Karen M. T. Astvad, Rasmus Krøger Hare, Maiken Cavling Arendrup
  • Susceptibility
    Rifampin Enhances the Activity of Amphotericin B against Fusarium solani Species Complex and Aspergillus flavus Species Complex Isolates from Keratitis Patients
    Yi He, Lutan Zhou, Chuanwen Gao, Lei Han, Yan Xu
  • Susceptibility
    Comparative Evaluation of Etest, EUCAST, and CLSI Methods for Amphotericin B, Voriconazole, and Posaconazole against Clinically Relevant Fusarium Species
    Abdullah M. S. Al-Hatmi, Anne-Cécile Normand, Stephane Ranque, Renaud Piarroux, G. Sybren de Hoog, Joseph Meletiadis, Jacques F. Meis

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