gallium
Experimental TherapeuticsIron/Heme Metabolism-Targeted Gallium(III) Nanoparticles Are Active against Extracellular and Intracellular Pseudomonas aeruginosa and Acinetobacter baumanniiIron/heme acquisition systems are critical for microorganisms to acquire iron from the human host, where iron sources are limited due to the nutritional immune system and insolubility of the ferric form of iron. Prior work has shown that a variety of gallium compounds can interfere with bacterial iron acquisition.
- Mechanisms of Action: Physiological EffectsAcinetobacter baumannii Biofilm Formation in Human Serum and Disruption by Gallium