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genotype

  • Associations between Aminoquinoline Resistance Genotypes and Clinical Presentations of <span class="named-content genus-species" id="named-content-1">Plasmodium falciparum</span> Infection in Uganda
    Mechanisms of Resistance
    Associations between Aminoquinoline Resistance Genotypes and Clinical Presentations of Plasmodium falciparum Infection in Uganda

    Mutations that mediate resistance of Plasmodium falciparum to aminoquinoline antimalarials are selected by prior drug use and may alter parasite fitness, but associations with clinical presentations are uncertain. We evaluated genotypes in samples from a case-control study of determinants of severe malaria in Ugandan children 4 months to 10 years of age. We studied...

    Gloria Cuu, Victor Asua, Stephen Tukwasibwe, Sam L. Nsobya, Ann Nanteza, Magambo Phillip Kimuda, Arthur Mpimbaza, Philip J. Rosenthal
  • Decreased Incidence of Methicillin-Resistant <span class="named-content genus-species" id="named-content-1">Staphylococcus aureus</span> Bacteremia in Intensive Care Units: a 10-Year Clinical, Microbiological, and Genotypic Analysis in a Tertiary Hospital
    Epidemiology and Surveillance
    Decreased Incidence of Methicillin-Resistant Staphylococcus aureus Bacteremia in Intensive Care Units: a 10-Year Clinical, Microbiological, and Genotypic Analysis in a Tertiary Hospital

    There are limited long-term data on the trends in incidence and characteristics of methicillin-resistant Staphylococcus aureus (MRSA) bacteremia (MRSAB) in intensive care units (ICUs) in which infection control measures have been adopted. We evaluated the trend of incidence and changes in characteristics of MRSA bacteremia in ICUs at a tertiary-care hospital over 10 ...

    Haein Kim, Eun Sil Kim, Seung Cheol Lee, Eunmi Yang, Hee Sueng Kim, Heungsup Sung, Mi-Na Kim, Jiwon Jung, Min Jae Kim, Sung-Han Kim, Sang-Oh Lee, Sang-Ho Choi, Jun Hee Woo, Yang Soo Kim, Yong Pil Chong
  • Molecular Testing of Serial Blood Specimens from Patients with Early Lyme Disease during Treatment Reveals Changing Coinfection with Mixtures of <span class="named-content genus-species" id="named-content-1">Borrelia burgdorferi</span> Genotypes
    Clinical Therapeutics
    Molecular Testing of Serial Blood Specimens from Patients with Early Lyme Disease during Treatment Reveals Changing Coinfection with Mixtures of Borrelia burgdorferi Genotypes

    Borrelia burgdorferi is the etiological agent of Lyme disease. In the current study, we used direct-detection PCR and electrospray ionization mass spectrometry to monitor and genotype B. burgdorferi isolates from serially collected whole-blood specimens from patients clinically diagnosed with early...

    Michael R. Mosel, Heather E. Carolan, Alison W. Rebman, Steven Castro, Christian Massire, David J. Ecker, Mark J. Soloski, John N. Aucott, Mark W. Eshoo
  • Mutation Profile of <em>pfdhfr</em> and <em>pfdhps</em> in <span class="named-content genus-species" id="named-content-1">Plasmodium falciparum</span> among Returned Chinese Migrant Workers from Africa
    Epidemiology and Surveillance
    Mutation Profile of pfdhfr and pfdhps in Plasmodium falciparum among Returned Chinese Migrant Workers from Africa

    We evaluated markers of sulfadoxine-pyrimethamine (SP) resistance in Plasmodium falciparum among 254 returned migrant workers in China from Africa from 2013 to 2016. High prevalences of pfdhfr (97.2%) and pfdhps (96.5%) mutations were observed.

    Chao Xu, Hui Sun, Qingkuan Wei, Jin Li, Ting Xiao, Xiangli Kong, Yongbin Wang, Guihua Zhao, Longjiang Wang, Gongzhen Liu, Ge Yan, Bingcheng Huang, Kun Yin
  • Genetic Correlation of Antibiotic Susceptibility and Resistance Genotyping for the <em>Mycobacterium abscessus</em> Group
    Editor's Pick Mechanisms of Resistance
    Genetic Correlation of Antibiotic Susceptibility and Resistance Genotyping for the Mycobacterium abscessus Group

    Treatment efficacy of Mycobacterium abscessus infections depends on bacterial genotype. Here, the relationship between genotype, as determined by sequence analysis, and antibiotic resistance phenotype was analyzed.

    Huiwen Zheng, Dongxin Liu, Jie Lu, Yuanyuan Song, Shengfen Wang, Yanlin Zhao, Xin Ni
  • Open Access
    Clinical Therapeutics
    The Clarithromycin Susceptibility Genotype Affects the Treatment Outcome of Patients with Mycobacterium abscessus Lung Disease
    Qi Guo, Haiqing Chu, Meiping Ye, Zhemin Zhang, Bing Li, Shiyi Yang, Wei Ma, Fangyou Yu
  • Mechanisms of Resistance
    Establishing Genotypic Cutoff Values To Measure Antimicrobial Resistance in Salmonella
    Gregory H. Tyson, Shaohua Zhao, Cong Li, Sherry Ayers, Jonathan L. Sabo, Claudia Lam, Ron A. Miller, Patrick F. McDermott
  • Susceptibility
    Genotypic versus Phenotypic Characterization, with Respect to β-Lactam Susceptibility, of Haemophilus influenzae Isolates Exhibiting Decreased Susceptibility to β-Lactam Resistance Markers
    David Sevillano, María-José Giménez, Emilia Cercenado, Fabio Cafini, Amadeo Gené, Luis Alou, Francesc Marco, Luis Martínez-Martínez, Pilar Coronel, Lorenzo Aguilar
  • Mechanisms of Resistance
    Evolution of Drug Resistance in Different Sublineages of Mycobacterium tuberculosis Beijing Genotype
    Igor Mokrousov, Wei Wei Jiao, Gui Zhi Sun, Jia Wen Liu, Violeta Valcheva, Mo Li, Olga Narvskaya, A Dong Shen
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