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glomerular filtration rate

  • Reappraisal of Linezolid Dosing in Renal Impairment To Improve Safety
    Pharmacology
    Reappraisal of Linezolid Dosing in Renal Impairment To Improve Safety

    Linezolid is administered as a fixed dose to all patients despite evidence of increased exposure and myelosuppression in renal impairment. The objectives of these studies were to assess the risk of thrombocytopenia with standard-dose linezolid in renal impairment and to identify an alternate dosing strategy.

    Ryan L. Crass, Pier Giorgio Cojutti, Manjunath P. Pai, Federico Pea
  • Pharmacology
    Population Pharmacokinetics of Ceftazidime in Intensive Care Unit Patients: Influence of Glomerular Filtration Rate, Mechanical Ventilation, and Reason for Admission
    Bernard Georges, Jean-Marie Conil, Thierry Seguin, Stéphanie Ruiz, Vincent Minville, Pierre Cougot, Jean-François Decun, Hélène Gonzalez, Georges Houin, Olivier Fourcade, Sylvie Saivin
  • Pharmacology
    Assessment of the Effects of the Nitroimidazo-Oxazine PA-824 on Renal Function in Healthy Subjects
    Ann M. Ginsberg, Martino W. Laurenzi, Doris J. Rouse, Karl D. Whitney, Mel K. Spigelman
  • Clinical Therapeutics
    Comparative Study of the Effects of Pyridoxine, Rifampin, and Renal Function on Hematological Adverse Events Induced by Linezolid
    Alex Soriano, Mar Ortega, Sebastián García, Georgina Peñarroja, Albert Bové, Miguel Marcos, Juan C. Martínez, José A. Martínez, Josep Mensa
  • Pharmacology
    Lack of Effect of DX-619, a Novel Des-Fluoro(6)-Quinolone, on Glomerular Filtration Rate Measured by Serum Clearance of Cold Iohexol
    Nenad Sarapa, Prachi Wickremasingha, NanXiang Ge, Richard Weitzman, Merynda Fuellhart, Cindy Yen, Julia Lloyd-Parks
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