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glycopeptides

  • A Systematic Review of Studies Reporting Antibiotic Pharmacokinetic Data in the Cerebrospinal Fluid of Critically Ill Patients with Uninflamed Meninges
    Clinical Therapeutics
    A Systematic Review of Studies Reporting Antibiotic Pharmacokinetic Data in the Cerebrospinal Fluid of Critically Ill Patients with Uninflamed Meninges

    Ventriculostomy-associated infections in critically ill patients remain therapeutically challenging because of drug- and disease-related factors that contribute to suboptimal antibiotic concentrations in cerebrospinal fluid. Optimal antibiotic dosing for the treatment and prevention of such infections should be based on robust and contextually specific pharmacokinetic data. The objects of this study were to describe and critically...

    Nilesh Kumta, Jason A. Roberts, Jeffrey Lipman, Wai Tat Wong, Gavin M. Joynt, Menino Osbert Cotta
  • Pharmacokinetics of Telavancin in Adult Patients with Cystic Fibrosis during Acute Pulmonary Exacerbation
    Pharmacology
    Pharmacokinetics of Telavancin in Adult Patients with Cystic Fibrosis during Acute Pulmonary Exacerbation

    Adults with cystic fibrosis (CF) frequently harbor Staphylococcus aureus, which is increasingly antibiotic resistant. Telavancin is a once-daily rapidly bactericidal antibiotic active against methicillin-, linezolid-, and ceftaroline-resistant S. aureus. Because CF patients experience alterations in...

    James M. Kidd, Colleen M. Sakon, Louise-Marie Oleksiuk, Jeffrey J. Cies, Rebecca S. Pettit, David P. Nicolau, Joseph L. Kuti
  • Epidemiology and Surveillance
    Antimicrobial Activity of Dalbavancin against Staphylococcus aureus with Decreased Susceptibility to Glycopeptides, Daptomycin, and/or Linezolid from U.S. Medical Centers
    Helio S. Sader, Rodrigo E. Mendes, Leonard R. Duncan, Michael A. Pfaller, Robert K. Flamm
  • Susceptibility
    In Vitro Susceptibility of Mycobacterium tuberculosis to Amikacin, Kanamycin, and Capreomycin
    J. A. Dijkstra, T. van der Laan, O. W. Akkerman, M. S. Bolhuis, W. C. M. de Lange, J. G. W. Kosterink, T. S. van der Werf, J. W. C. Alffenaar, D. van Soolingen
  • Experimental Therapeutics
    Combination Antibiotic Exposure Selectively Alters the Development of Vancomycin Intermediate Resistance in Staphylococcus aureus
    Xuting Zheng, Andrew D. Berti, Sue McCrone, Melanie Roch, Adriana E. Rosato, Warren E. Rose, Baiyi Chen
  • Pharmacology
    Comparative Pharmacodynamics of Single-Dose Oritavancin and Daily High-Dose Daptomycin Regimens against Vancomycin-Resistant Enterococcus faecium Isolates in an In Vitro Pharmacokinetic/Pharmacodynamic Model of Infection
    Adam Belley, David Lalonde-Séguin, Francis F. Arhin, Greg Moeck
  • Pharmacology
    Effects of Oritavancin on Coagulation Tests in the Clinical Laboratory
    Adam Belley, Richard Robson, John L. Francis, Dorothy M. Adcock, Stefan Tiefenbacher, Christopher M. Rubino, Greg Moeck, David Sylvester, Michael N. Dudley, Jeffery Loutit
  • Mechanisms of Action: Physiological Effects
    Oritavancin Disrupts Membrane Integrity of Staphylococcus aureus and Vancomycin-Resistant Enterococci To Effect Rapid Bacterial Killing
    Adam Belley, Geoffrey A. McKay, Francis F. Arhin, Ingrid Sarmiento, Sylvain Beaulieu, Ibthihal Fadhil, Thomas R. Parr, Gregory Moeck
  • Mechanisms of Resistance
    vanM, a New Glycopeptide Resistance Gene Cluster Found in Enterococcus faecium
    Xiaogang Xu, Dongfang Lin, Guoquan Yan, Xinyu Ye, Shi Wu, Yan Guo, Demei Zhu, Fupin Hu, Yingyuan Zhang, Fu Wang, George A. Jacoby, Minggui Wang
  • Susceptibility
    In Vitro Activity of the New Multivalent Glycopeptide-Cephalosporin Antibiotic TD-1792 against Vancomycin-Nonsusceptible Staphylococcus Isolates
    Kimberly D. Leuthner, Celine Vidaillac, Chrissy M. Cheung, Michael J. Rybak

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