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gonorrhea

  • Open Access
    Atypical Mutation in <span class="named-content genus-species" id="named-content-1">Neisseria gonorrhoeae</span> 23S rRNA Associated with High-Level Azithromycin Resistance
    Mechanisms of Resistance
    Atypical Mutation in Neisseria gonorrhoeae 23S rRNA Associated with High-Level Azithromycin Resistance

    A2059G mutation in the 23S rRNA gene is the only reported mechanism conferring high-level azithromycin resistance (HL-AZMR) in Neisseria gonorrhoeae. Through U.S. gonococcal antimicrobial resistance surveillance projects, we identified four HL-AZMR gonococcal isolates lacking this mutational genotype. Genetic analysis revealed an A2058G mutation of 23S rRNA alleles in...

    Cau D. Pham, Evelyn Nash, Hsi Liu, Matthew W. Schmerer, Samera Sharpe, Grace Woods, Brad Roland, Karen Schlanger, Sancta B. St. Cyr, Jonathan Carlson, Kevin Sellers, Aaron Olsen, Ruth Sanon, Henrietta Hardin, Olusegun O. Soge, Brian H. Raphael, Ellen N. Kersh
    and on behalf of the AR Lab Network Workgroup for GC
  • High <em>In Vitro</em> Susceptibility to the First-in-Class Spiropyrimidinetrione Zoliflodacin among Consecutive Clinical <span class="named-content genus-species" id="named-content-1">Neisseria gonorrhoeae</span> Isolates from Thailand and South Africa
    Susceptibility
    High In Vitro Susceptibility to the First-in-Class Spiropyrimidinetrione Zoliflodacin among Consecutive Clinical Neisseria gonorrhoeae Isolates from Thailand and South Africa

    We evaluated the in vitro susceptibility to the first-in-class spiropyrimidinetrione zoliflodacin among recent consecutive clinical Neisseria gonorrhoeae isolates cultured in Thailand (n = 99) (in 2018) and South Africa (n = 100) (in 2015 to 2017).

    Susanne Jacobsson, Ranmini Kularatne, Rossaphorn Kittiyaowamarn, Venessa Maseko, Porntip Paopang, Pongsathorn Sangprasert, Pachara Sirivongrangson, Laura Piddock, Teodora Wi, Emilie Alirol, Magnus Unemo
  • Impact of Species Diversity on the Design of RNA-Based Diagnostics for Antibiotic Resistance in <em>Neisseria gonorrhoeae</em>
    Susceptibility
    Impact of Species Diversity on the Design of RNA-Based Diagnostics for Antibiotic Resistance in Neisseria gonorrhoeae

    Quantitative assessment of antibiotic-responsive RNA transcripts holds promise for a rapid point-of-care (POC) diagnostic tool for antimicrobial susceptibility testing. These assays aim to distinguish susceptible and resistant isolates by transcriptional differences upon drug exposure. However, an often-overlooked dimension of designing these tests is that the genetic diversity within a species may yield differential transcriptional...

    Crista B. Wadsworth, Mohamad R. A. Sater, Roby P. Bhattacharyya, Yonatan H. Grad
  • Pharmacokinetic Data Are Predictive of <em>In Vivo</em> Efficacy for Cefixime and Ceftriaxone against Susceptible and Resistant <em>Neisseria gonorrhoeae</em> Strains in the Gonorrhea Mouse Model
    Pharmacology
    Pharmacokinetic Data Are Predictive of In Vivo Efficacy for Cefixime and Ceftriaxone against Susceptible and Resistant Neisseria gonorrhoeae Strains in the Gonorrhea Mouse Model

    There is a pressing need for drug development for gonorrhea. Here we describe a pharmacokinetic (PK)/pharmacodynamic (PD) analysis of extended-spectrum cephalosporins (ESC) against drug-susceptible and drug-resistant gonococcal strains in a murine genital tract infection model.

    Kristie L. Connolly, Ann E. Eakin, Carolina Gomez, Blaire L. Osborn, Magnus Unemo, Ann E. Jerse
  • Mechanisms of Resistance
    cis- and trans-Acting Factors Influence Expression of the norM-Encoded Efflux Pump of Neisseria gonorrhoeae and Levels of Gonococcal Susceptibility to Substrate Antimicrobials

    The gonococcal NorM efflux pump exports substrates with a cationic moiety, including quaternary ammonium compounds such as berberine (BE) and ethidium bromide (EB) as well as antibiotics such as ciprofloxacin and solithromycin. The norM gene is part of a four-gene operon that is transcribed from a promoter containing a polynucleotide tract of 6 or 7 thymidines (T's) between the −10 and −35 hexamers; the majority of gonococcal...

    Corinne E. Rouquette-Loughlin, Vijaya Dhulipala, Jennifer L. Reimche, Erica Raterman, Afrin A. Begum, Ann E. Jerse, William M. Shafer
  • Experimental Therapeutics
    Aminomethyl Spectinomycins as Therapeutics for Drug-Resistant Gonorrhea and Chlamydia Coinfections
    Michelle M. Butler, Samanthi L. Waidyarachchi, Kristie L. Connolly, Ann E. Jerse, Weirui Chai, Richard E. Lee, Stephan A. Kohlhoff, Dean L. Shinabarger, Terry L. Bowlin
  • Epidemiology and Surveillance
    Real-Time PCR Targeting the penA Mosaic XXXIV Type for Prediction of Extended-Spectrum-Cephalosporin Susceptibility in Clinical Neisseria gonorrhoeae Isolates
    L. K. Wong, P. Hemarajata, O. O. Soge, R. M. Humphries, J. D. Klausner
  • Susceptibility
    In Vitro Activity of the Novel Pleuromutilin Lefamulin (BC-3781) and Effect of Efflux Pump Inactivation on Multidrug-Resistant and Extensively Drug-Resistant Neisseria gonorrhoeae
    Susanne Jacobsson, Susanne Paukner, Daniel Golparian, Jörgen S. Jensen, Magnus Unemo
  • Experimental Therapeutics
    Peptide Inhibitors Targeting the Neisseria gonorrhoeae Pivotal Anaerobic Respiration Factor AniA
    Aleksandra E. Sikora, Robert H. Mills, Jacob V. Weber, Adel Hamza, Bryan W. Passow, Andrew Romaine, Zachary A. Williamson, Robert W. Reed, Ryszard A. Zielke, Konstantin V. Korotkov
  • Mechanisms of Resistance
    Spread of a Chromosomal Cefixime-Resistant penA Gene among Different Neisseria gonorrhoeae Lineages
    Makoto Ohnishi, Yuko Watanabe, Emi Ono, Chieko Takahashi, Hitomi Oya, Toshiro Kuroki, Ken Shimuta, Norio Okazaki, Shu-ichi Nakayama, Haruo Watanabe

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