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Gram-positive bacteria

  • Open Access
    Nitroxide Functionalized Antibiotics Are Promising Eradication Agents against <span class="named-content genus-species" id="named-content-1">Staphylococcus aureus</span> Biofilms
    Experimental Therapeutics
    Nitroxide Functionalized Antibiotics Are Promising Eradication Agents against Staphylococcus aureus Biofilms

    Treatment of biofilm-related Staphylococcus aureus infections represents an important medical challenge worldwide, as biofilms, even those involving drug-susceptible S. aureus strains, are highly refractory to conventional antibiotic therapy. Nitroxides were recently shown to induce the dispersal of...

    Anthony D. Verderosa, Rabeb Dhouib, Kathryn E. Fairfull-Smith, Makrina Totsika
  • <em>In Vitro</em> Activity of Iclaprim against Isolates in Two Phase 3 Clinical Trials (REVIVE-1 and -2) for Acute Bacterial Skin and Skin Structure Infections
    Susceptibility
    In Vitro Activity of Iclaprim against Isolates in Two Phase 3 Clinical Trials (REVIVE-1 and -2) for Acute Bacterial Skin and Skin Structure Infections

    Iclaprim, a selective bacterial dihydrofolate reductase inhibitor, and other antibiotics were tested against Gram-positive isolates from two phase 3 studies of acute bacterial skin and skin structure infections (ABSSSIs) (REVIVE-1 and -2). Seven hundred ninety baseline isolates, including Staphylococcus aureus, β-hemolytic streptococci, and...

    Stephanie Noviello, Sophie Magnet, Stephen Hawser, David B. Huang
  • <em>In Vitro</em> Activity of Plazomicin against Gram-Negative and Gram-Positive Bacterial Pathogens Isolated from Patients in Canadian Hospitals from 2013 to 2017 as Part of the CANWARD Surveillance Study
    Susceptibility
    In Vitro Activity of Plazomicin against Gram-Negative and Gram-Positive Bacterial Pathogens Isolated from Patients in Canadian Hospitals from 2013 to 2017 as Part of the CANWARD Surveillance Study

    The Clinical and Laboratory Standards Institute (CLSI) broth microdilution method was used to evaluate the in vitro activities of plazomicin and comparator antimicrobial agents against 7,712 Gram-negative and 4,481 Gram-positive bacterial pathogens obtained from 2013 to 2017 from patients in Canadian hospitals as part of the CANWARD Surveillance Study. Plazomicin demonstrated potent in vitro activity against ...

    Andrew Walkty, James A. Karlowsky, Melanie R. Baxter, Heather J. Adam, George G. Zhanel
  • Experimental Therapeutics
    Development of Methionyl-tRNA Synthetase Inhibitors as Antibiotics for Gram-Positive Bacterial Infections
    Omeed Faghih, Zhongsheng Zhang, Ranae M. Ranade, J. Robert Gillespie, Sharon A. Creason, Wenlin Huang, Sayaka Shibata, Ximena Barros-Álvarez, Christophe L. M. J. Verlinde, Wim G. J. Hol, Erkang Fan, Frederick S. Buckner
  • Experimental Therapeutics
    Genomewide Analysis of the Antimicrobial Peptides in Python bivittatus and Characterization of Cathelicidins with Potent Antimicrobial Activity and Low Cytotoxicity
    Dayeong Kim, Nagasundarapandian Soundrarajan, Juyeon Lee, Hye-sun Cho, Minkyeung Choi, Se-Yeoun Cha, Byeongyong Ahn, Hyoim Jeon, Minh Thong Le, Hyuk Song, Jin-Hoi Kim, Chankyu Park
  • Pharmacology
    Safety, Tolerability, Systemic Exposure, and Metabolism of CRS3123, a Methionyl-tRNA Synthetase Inhibitor Developed for Treatment of Clostridium difficile, in a Phase 1 Study
    Seema U. Nayak, J. McLeod Griffiss, Jeffrey Blumer, Mary Ann O'Riordan, Wesley Gray, Robin McKenzie, Robert A. Jurao, Amanda T. An, Melissa Le, Stacie J. Bell, Urs A. Ochsner, Thale C. Jarvis, Nebojsa Janjic, Jonathan M. Zenilman
  • Biologic Response Modifiers
    Signal Biosynthesis Inhibition with Ambuic Acid as a Strategy To Target Antibiotic-Resistant Infections
    Daniel A. Todd, Corey P. Parlet, Heidi A. Crosby, Cheryl L. Malone, Kristopher P. Heilmann, Alexander R. Horswill, Nadja B. Cech
  • Susceptibility
    Gepotidacin (GSK2140944) In Vitro Activity against Gram-Positive and Gram-Negative Bacteria
    R. K. Flamm, D. J. Farrell, P. R. Rhomberg, N. E. Scangarella-Oman, H. S. Sader
  • Open Access
    Clinical Therapeutics
    Efficacy, Safety, and Tolerability of Gepotidacin (GSK2140944) in the Treatment of Patients with Suspected or Confirmed Gram-Positive Acute Bacterial Skin and Skin Structure Infections
    William O'Riordan, Courtney Tiffany, Nicole Scangarella-Oman, Caroline Perry, Mohammad Hossain, Teri Ashton, Etienne Dumont
  • Susceptibility
    Comparative In Vitro Activity Profiles of Novel Bis-Indole Antibacterials against Gram-Positive and Gram-Negative Clinical Isolates
    Michelle M. Butler, John D. Williams, Norton P. Peet, Donald T. Moir, Rekha G. Panchal, Sina Bavari, Dean L. Shinabarger, Terry L. Bowlin

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