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hemodialysis

  • Free
    Removal of Remdesivir’s Metabolite GS-441524 by Hemodialysis in a Double Lung Transplant Recipient with COVID-19
    Antiviral Agents
    Removal of Remdesivir’s Metabolite GS-441524 by Hemodialysis in a Double Lung Transplant Recipient with COVID-19

    Remdesivir has reported efficacy against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in vitro and in vivo. Drug-drug interactions limit therapeutic options in transplant patients. Remdesivir and its metabolite GS-441524 are excreted principally in urine. In intensive care unit (ICU) settings, in which multiple-organ dysfunctions can occur rapidly, hemodialysis may be a viable option for maintaining...

    Minh Patrick Lê, Quentin Le Hingrat, Pierre Jaquet, Paul-Henri Wicky, Vincent Bunel, Laurent Massias, Benoit Visseaux, Jonathan Messika, Diane Descamps, Hervé Mal, Jean-François Timsit, Gilles Peytavin
  • A Thrice-Weekly Ertapenem Regimen Is Practical for Hemodialysis Patients
    Clinical Therapeutics
    A Thrice-Weekly Ertapenem Regimen Is Practical for Hemodialysis Patients

    A change of ertapenem dosage from 500 mg daily to thrice weekly, after each hemodialysis session, can maintain the plasma concentration above 2 mg/liter and be practical for hemodialysis patients.

    Yune-Fang Ueng, Hong-Jaan Wang, Shiao-Chi Wu, Yee-Yung Ng
  • Pharmacology
    Elimination of Doripenem during Dialysis and Pharmacokinetic Evaluation of Posthemodialysis Dosing for Patients Undergoing Intermittent Renal Replacement Therapy
    M. G. Vossen, L. Ehmann, S. Pferschy, A. Maier-Salamon, M. Haidinger, C. Weiser, J. M. Wenisch, K. Saria, C. Kajahn, S. Jilch, R. Lemmerer, M. Bécède, M. Zeitlinger, C. Kloft, W. Jäger, F. Thalhammer
  • Clinical Therapeutics
    Single-Dose Pharmacokinetics and Safety of Meropenem-Vaborbactam in Subjects with Chronic Renal Impairment
    Christopher M. Rubino, Sujata M. Bhavnani, Jeffery S. Loutit, Brooke Lohse, Michael N. Dudley, David C. Griffith
  • Antiviral Agents
    Effects of Renal Impairment and Hemodialysis on the Pharmacokinetics and Safety of the Glecaprevir and Pibrentasvir Combination in Hepatitis C Virus-Negative Subjects
    Matthew P. Kosloski, Weihan Zhao, Thomas C. Marbury, Richard A. Preston, Michael G. Collins, David Pugatch, Federico Mensa, Jens Kort, Wei Liu
  • Pharmacology
    Ethambutol Is Cleared by a Contemporary High-Flux Hemodialyzer, and Drug Monitoring Ensures Safety and Therapeutic Effect
    Rusheng Chew, Sarah Jongbloed, Dev Jegatheesan, Helen Healy, Kim Ta, Jacobus Ungerer, Brett McWhinney, Peter Donovan, Marion L. Woods
  • Pharmacology
    Pharmacokinetic/Pharmacodynamic Modeling and Simulation of Cefiderocol, a Parenteral Siderophore Cephalosporin, for Dose Adjustment Based on Renal Function
    Takayuki Katsube, Toshihiro Wajima, Toru Ishibashi, Juan Camilo Arjona Ferreira, Roger Echols
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