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heteroresistance

  • Vancomycin Heteroresistance and Clinical Outcomes in Bloodstream Infections Caused by Coagulase-Negative Staphylococci
    Editor's Pick Mechanisms of Resistance
    Vancomycin Heteroresistance and Clinical Outcomes in Bloodstream Infections Caused by Coagulase-Negative Staphylococci

    Coagulase-negative staphylococci (CoNS) are a common etiology of serious and recurrent infections in immunocompromised patients. Although most isolates appear susceptible to vancomycin, a single strain might have a subpopulation of resistant bacteria. This phenomenon is termed heteroresistance and may adversely affect the response to treatment. A retrospective cohort study was performed of pediatric patients with leukemia treated at St...

    Tina H. Dao, Ramzi Alsallaq, Joshua B. Parsons, Jose Ferrolino, Randall T. Hayden, Jeffrey E. Rubnitz, Iftekhar M. Rafiqullah, D. Ashley Robinson, Elisa B. Margolis, Jason W. Rosch, Joshua Wolf
  • Open Access
    Omadacycline Efficacy against <span class="named-content genus-species" id="named-content-1">Enterococcus faecalis</span> Isolated in China: <em>In Vitro</em> Activity, Heteroresistance, and Resistance Mechanisms
    Editor's Pick Mechanisms of Resistance
    Omadacycline Efficacy against Enterococcus faecalis Isolated in China: In Vitro Activity, Heteroresistance, and Resistance Mechanisms

    This study aimed to evaluate the in vitro antimicrobial activity, heteroresistance emergence, and resistance mechanism of omadacycline (OMC) in clinical Enterococcus faecalis isolates from China. A total of 276 isolates were collected retrospectively in China from 2011 to 2015. The MICs of OMC, doxycycline (DOX), and minocycline (MIN) against...

    Zhiwei Lin, Zhangya Pu, Guangjian Xu, Bing Bai, Zhong Chen, Xiang Sun, Jinxin Zheng, Peiyu Li, Di Qu, Qiwen Deng, Zhijian Yu
  • Utility of Targeted, Amplicon-Based Deep Sequencing To Detect Resistance to First-Line Tuberculosis Drugs in Botswana
    Analytical Procedures
    Utility of Targeted, Amplicon-Based Deep Sequencing To Detect Resistance to First-Line Tuberculosis Drugs in Botswana

    Multidrug-resistant tuberculosis (TB) is an alarming threat, and targeted deep sequencing (DS) may be an effective method for rapid identification of drug-resistant profiles, including detection of heteroresistance. We evaluated the sensitivity and specificity of targeted DS versus phenotypic drug susceptibility testing (pDST) among patients starting first-line anti-TB therapy in Botswana. Overall, we found high concordance between DS...

    Qiao Wang, Chawangwa Modongo, Christopher Allender, David M. Engelthaler, Robin M. Warren, Nicola M. Zetola, Sanghyuk S. Shin
  • Resistance and Heteroresistance to Colistin in <span class="named-content genus-species" id="named-content-1">Pseudomonas aeruginosa</span> Isolates from Wenzhou, China
    Mechanisms of Resistance
    Resistance and Heteroresistance to Colistin in Pseudomonas aeruginosa Isolates from Wenzhou, China

    The goal was to investigate the mechanisms of colistin resistance and heteroresistance in Pseudomonas aeruginosa clinical isolates. Colistin resistance was determined by the broth microdilution method. Colistin heteroresistance was evaluated by population analysis profiling. Time-kill assays were also conducted. PCR sequencing was performed to detect the resistance...

    Jie Lin, Chunquan Xu, Renchi Fang, Jianming Cao, Xiucai Zhang, Yajie Zhao, Guofeng Dong, Yao Sun, Tieli Zhou
  • A Nationwide Screen of Carbapenem-Resistant <span class="named-content genus-species" id="named-content-1">Klebsiella pneumoniae</span> Reveals an Isolate with Enhanced Virulence and Clinically Undetected Colistin Heteroresistance
    Epidemiology and Surveillance
    A Nationwide Screen of Carbapenem-Resistant Klebsiella pneumoniae Reveals an Isolate with Enhanced Virulence and Clinically Undetected Colistin Heteroresistance

    The convergence of hypervirulence and multidrug resistance in Klebsiella pneumoniae is a significant concern. Here, we report the first screen for hypermucoviscosity, a trait associated with increased virulence, using a U.S.

    Jessie E. Wozniak, Victor I. Band, Andrew B. Conley, Lavanya Rishishwar, Eileen M. Burd, Sarah W. Satola, Dwight J. Hardy, Rebecca Tsay, Monica M. Farley, Jesse T. Jacob, Ghinwa Dumyati, I. King Jordan, David S. Weiss
  • Early Detection of Emergent Extensively Drug-Resistant Tuberculosis by Flow Cytometry-Based Phenotyping and Whole-Genome Sequencing
    Susceptibility
    Early Detection of Emergent Extensively Drug-Resistant Tuberculosis by Flow Cytometry-Based Phenotyping and Whole-Genome Sequencing

    A critical gap in tuberculosis (TB) treatment is detection of emergent drug resistance. We hypothesized that advanced phenotyping with whole-genome sequencing (WGS) will detect low-frequency Mycobacterium tuberculosis drug resistance.

    Max R. O’Donnell, Michelle H. Larsen, Tyler S. Brown, Paras Jain, Vanisha Munsamy, Allison Wolf, Lorenzo Uccellini, Farina Karim, Tulio de Oliveira, Barun Mathema, William R. Jacobs, Alexander Pym
  • Mechanisms of Resistance
    Colistin Heteroresistance and Involvement of the PmrAB Regulatory System in Acinetobacter baumannii

    Multidrug-resistant Acinetobacter baumannii infection has recently emerged as a worldwide clinical problem, and colistin is increasingly being used as a last-resort therapy. Despite its favorable bacterial killing, resistance and heteroresistance (HR) to colistin have been described.

    Yannick Charretier, Seydina M. Diene, Damien Baud, Sonia Chatellier, Emmanuelle Santiago-Allexant, Alex van Belkum, Ghislaine Guigon, Jacques Schrenzel
  • Open Access
    Mechanisms of Resistance
    Genetic Basis of Emerging Vancomycin, Linezolid, and Daptomycin Heteroresistance in a Case of Persistent Enterococcus faecium Bacteremia
    Kieran I. Chacko, Mitchell J. Sullivan, Colleen Beckford, Deena R. Altman, Brianne Ciferri, Theodore R. Pak, Robert Sebra, Andrew Kasarskis, Camille L. Hamula, Harm van Bakel
  • Letter to the Editor
    Heteroresistance to Piperacillin-Tazobactam in Clinical Isolates of Escherichia coli Sequence Type 131
    Ángel Rodríguez-Villodres, José Manuel Ortiz de la Rosa, Rocío Álvarez-Marín, Jerónimo Pachón, Javier Aznar, José Antonio Lepe, Younes Smani
  • Mechanisms of Resistance
    Mycobacterium tuberculosis Subculture Results in Loss of Potentially Clinically Relevant Heteroresistance
    John Z. Metcalfe, Elizabeth Streicher, Grant Theron, Rebecca E. Colman, Renee Penaloza, Christopher Allender, Darrin Lemmer, Robin M. Warren, David M. Engelthaler

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