histopathology

  • Open Access
    A Subcutaneous Implant of Tenofovir Alafenamide Fumarate Causes Local Inflammation and Tissue Necrosis in Rabbits and Macaques
    Antiviral Agents
    A Subcutaneous Implant of Tenofovir Alafenamide Fumarate Causes Local Inflammation and Tissue Necrosis in Rabbits and Macaques

    We describe the in vitro and in vivo evaluation of a subcutaneous reservoir implant delivering tenofovir alafenamide hemifumarate (TAF) for the prevention of HIV infection. These long-acting reservoir implants were able to deliver antiretroviral drug for over 90 days in vitro and in vivo. We evaluated the implants for implantation site histopathology and pharmacokinetics in plasma and tissues for up...

    Jonathan T. Su, Solange M. Simpson, Samuel Sung, Ewa Bryndza Tfaily, Ronald Veazey, Mark Marzinke, Jiang Qiu, David Watrous, Lakmini Widanapathirana, Elizabeth Pearson, M. Melissa Peet, Dipu Karunakaran, Brooke Grasperge, Georgina Dobek, Charlette M. Cain, Thomas Hope, Patrick F. Kiser
  • Comparative Performance of Urinary Biomarkers for Vancomycin-Induced Kidney Injury According to Timeline of Injury
    Pharmacology
    Comparative Performance of Urinary Biomarkers for Vancomycin-Induced Kidney Injury According to Timeline of Injury

    Urinary biomarkers are superior to serum creatinine for defining onset and extent of kidney injury. This study classifies the temporal predictive ability of biomarkers for vancomycin-induced kidney injury (VIKI) as defined by histopathologic damage.

    Gwendolyn M. Pais, Sean N. Avedissian, J. Nicholas O’Donnell, Nathaniel J. Rhodes, Thomas P. Lodise, Walter C. Prozialeck, Peter C. Lamar, Cameron Cluff, Anil Gulati, Julie C. Fitzgerald, Kevin J. Downes, Athena F. Zuppa, Marc H. Scheetz
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