HIV infection
Antiviral AgentsZidovudine-Mediated Autophagy Inhibition Enhances Mitochondrial Toxicity in Muscle CellsNucleoside reverse transcriptase inhibitors (NRTI), such as zidovudine (AZT), are constituents of HIV-1 therapy and are used for the prevention of mother-to-child transmission. Prolonged thymidine analogue exposure has been associated with mitochondrial toxicities to heart, liver, and skeletal muscle.