host-directed therapy
Experimental TherapeuticsDisparate Effects of Metformin on Mycobacterium tuberculosis Infection in Diabetic and Nondiabetic MiceComorbid type 2 diabetes poses a great challenge to the global control of tuberculosis. Here, we assessed the efficacy of metformin (MET), an antidiabetic drug, in mice infected with a very low dose of Mycobacterium tuberculosis. In contrast to diabetic mice, infected nondiabetic mice that received the same therapeutic concentration of MET presented with significantly...
Experimental TherapeuticsTHP-1 and Dictyostelium Infection Models for Screening and Characterization of Anti-Mycobacterium abscessus Hit Compounds!!NCR1!! presents a great challenge to antimycobacterial therapy due to its innate resistance against most antibiotics. M. abscessus is able to grow intracellularly in human macrophages, suggesting that intracellular models can facilitate drug discovery. Thus, we have developed two host cell models: human macrophages for use in a new high-content screening...
- Experimental TherapeuticsAn Immunomodulatory Peptide Confers Protection in an Experimental Candidemia Murine Model
