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immune response

  • Novel Insights into <span class="named-content genus-species" id="named-content-1">Plasmodium vivax</span> Therapeutic Failure: CYP2D6 Activity and Time of Exposure to Malaria Modulate the Risk of Recurrence
    Epidemiology and Surveillance
    Novel Insights into Plasmodium vivax Therapeutic Failure: CYP2D6 Activity and Time of Exposure to Malaria Modulate the Risk of Recurrence

    Plasmodium vivax relapse is one of the major causes of sustained global malaria transmission. Primaquine (PQ) is the only commercial drug available to prevent relapses, and its efficacy is dependent on metabolic activation by cytochrome P450 2D6 (CYP2D6). Impaired CYP2D6 function, caused by allelic polymorphisms, leads to the therapeutic failure of PQ as a radical...

    Ana Carolina Rios Silvino, Flora Satiko Kano, Marcelo Azevedo Costa, Cor Jesus Fernandes Fontes, Irene Silva Soares, Cristiana Ferreira Alves de Brito, Luzia Helena Carvalho, Tais Nobrega Sousa
  • Development of Neutropenic Murine Models of Iron Overload and Depletion To Study the Efficacy of Siderophore-Antibiotic Conjugates
    Pharmacology
    Development of Neutropenic Murine Models of Iron Overload and Depletion To Study the Efficacy of Siderophore-Antibiotic Conjugates

    Siderophore-antibiotic conjugates have increased in vitro activity in low-iron environments where bacteria express siderophores and associated transporters. The host immune hypoferremic response reduces iron availability to bacteria; however, patients with iron overload or deficiency may have altered ability to restrict iron, which may affect the efficacy of siderophore-antibiotic conjugates. In vivo models of...

    James M. Kidd, Kamilia Abdelraouf, David P. Nicolau
  • Mechanisms of Action: Physiological Effects
    Commercial Intravenous Immunoglobulin Preparations Contain Functional Neutralizing Antibodies against the Staphylococcus aureus Leukocidin LukAB (LukGH)
    James B. Wood, Lauren S. Jones, Nicole R. Soper, Meera Nagarsheth, C. Buddy Creech, Isaac P. Thomsen
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