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infants

  • Optimal Dosing of Ceftriaxone in Infants Based on a Developmental Population Pharmacokinetic-Pharmacodynamic Analysis
    Pharmacology
    Optimal Dosing of Ceftriaxone in Infants Based on a Developmental Population Pharmacokinetic-Pharmacodynamic Analysis

    Ceftriaxone is a third-generation cephalosporin used to treat infants with community-acquired pneumonia. Currently, there is a large variability in the amount of ceftriaxone used for this purpose in this particular age group, and an evidence-based optimal dose is still unavailable. Therefore, we investigated the population pharmacokinetics of ceftriaxone in infants and performed a developmental pharmacokinetic-pharmacodynamic analysis...

    Ya-Kun Wang, Yue-E Wu, Xue Li, Li-Yuan Tian, Muhammad Wasim Khan, Bo-Hao Tang, Hai-Yan Shi, Yi Zheng, Guo-Xiang Hao, John van den Anker, Dian-Ping You, Wei Zhao
  • Rifampin Pharmacokinetics and Safety in Preterm and Term Infants
    Pharmacology
    Rifampin Pharmacokinetics and Safety in Preterm and Term Infants

    Rifampin is active against methicillin-resistant staphylococcal species and tuberculosis (TB). We performed a multicenter, prospective pharmacokinetic (PK) and safety study of intravenous rifampin in infants of <121 days postnatal age (PNA).

    P. Brian Smith, C. Michael Cotten, Mark L. Hudak, Janice E. Sullivan, Brenda B. Poindexter, Michael Cohen-Wolkowiez, Felix Boakye-Agyeman, Andrew Lewandowski, Ravinder Anand, Daniel K. Benjamin, Matthew M. Laughon, on behalf of the Best Pharmaceuticals for Children Act—Pediatric Trials Network Steering Committee
  • Pharmacology
    Pilot Study of Model-Based Dosage Individualization of Ganciclovir in Neonates and Young Infants with Congenital Cytomegalovirus Infection
    Qian Dong, Stephanie Leroux, Hai-Yan Shi, Hai-Yan Xu, Chen Kou, Muhammad Wasim Khan, Evelyne Jacqz-Aigrain, Wei Zhao
  • Pharmacology
    Penetration of Cefotaxime into Cerebrospinal Fluid in Neonates and Young Infants
    Xing-Kai Chen, Hai-Yan Shi, Stephanie Leroux, Hai-Yan Xu, Yue Zhou, Yi Zheng, Xin Huang, Yan Li, Evelyne Jacqz-Aigrain, Wei Zhao
  • Pharmacology
    Population Pharmacokinetics and Dosing Optimization of Ceftazidime in Infants
    Zhong-Ren Shi, Xing-Kai Chen, Li-Yuan Tian, Ya-Kun Wang, Gu-Ying Zhang, Lei Dong, Totsapol Jirasomprasert, Evelyne Jacqz-Aigrain, Wei Zhao
  • Clinical Therapeutics
    Population Pharmacokinetics of Trimethoprim-Sulfamethoxazole in Infants and Children
    Julie Autmizguine, Chiara Melloni, Christoph P. Hornik, Samantha Dallefeld, Barrie Harper, Ram Yogev, Janice E. Sullivan, Andrew M. Atz, Amira Al-Uzri, Susan Mendley, Brenda Poindexter, Jeff Mitchell, Andrew Lewandowski, Paula Delmore, Michael Cohen-Wolkowiez, Daniel Gonzalez
    and on behalf of the Pediatric Trials Network Steering Committee
  • Open Access
    Clinical Therapeutics
    Efficacy and Tolerability Outcomes of a Phase II, Randomized, Open-Label, Multicenter Study of a New Water-Dispersible Pediatric Formulation of Dihydroartemisinin-Piperaquine for the Treatment of Uncomplicated Plasmodium falciparum Malaria in African Infants
    Nicola Gargano, Lola Madrid, Giovanni Valentini, Umberto D'Alessandro, Tinto Halidou, Sodiomon Sirima, Antoinette Tshefu, Ali Mtoro, Samwel Gesase, The Eurartesim Dispersible Study Group, Quique Bassat
  • Open Access
    Antiviral Agents
    Safety, Tolerability, and Pharmacokinetics of MEDI8897, the Respiratory Syncytial Virus Prefusion F-Targeting Monoclonal Antibody with an Extended Half-Life, in Healthy Adults
    M. Pamela Griffin, Anis A. Khan, Mark T. Esser, Kathryn Jensen, Therese Takas, Martin K. Kankam, Tonya Villafana, Filip Dubovsky
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