infants

Pharmacology
Rifampin Pharmacokinetics and Safety in Preterm and Term Infants
Rifampin is active against methicillin-resistant staphylococcal species and tuberculosis (TB). We performed a multicenter, prospective pharmacokinetic (PK) and safety study of intravenous rifampin in infants of <121 days postnatal age (PNA).

P. Brian Smith, C. Michael Cotten, Mark L. Hudak, Janice E. Sullivan, Brenda B. Poindexter, Michael Cohen-Wolkowiez, Felix Boakye-Agyeman, Andrew Lewandowski, Ravinder Anand, Daniel K. Benjamin, Matthew M. Laughon, on behalf of the Best Pharmaceuticals for Children Act—Pediatric Trials Network Steering Committee
Pharmacology
Pilot Study of Model-Based Dosage Individualization of Ganciclovir in Neonates and Young Infants with Congenital Cytomegalovirus Infection
Qian Dong, Stephanie Leroux, Hai-Yan Shi, Hai-Yan Xu, Chen Kou, Muhammad Wasim Khan, Evelyne Jacqz-Aigrain, Wei Zhao
Pharmacology
Penetration of Cefotaxime into Cerebrospinal Fluid in Neonates and Young Infants
Xing-Kai Chen, Hai-Yan Shi, Stephanie Leroux, Hai-Yan Xu, Yue Zhou, Yi Zheng, Xin Huang, Yan Li, Evelyne Jacqz-Aigrain, Wei Zhao
Pharmacology
Population Pharmacokinetics and Dosing Optimization of Ceftazidime in Infants
Zhong-Ren Shi, Xing-Kai Chen, Li-Yuan Tian, Ya-Kun Wang, Gu-Ying Zhang, Lei Dong, Totsapol Jirasomprasert, Evelyne Jacqz-Aigrain, Wei Zhao
Clinical Therapeutics
Population Pharmacokinetics of Trimethoprim-Sulfamethoxazole in Infants and Children
Julie Autmizguine, Chiara Melloni, Christoph P. Hornik, Samantha Dallefeld, Barrie Harper, Ram Yogev, Janice E. Sullivan, Andrew M. Atz, Amira Al-Uzri, Susan Mendley, Brenda Poindexter, Jeff Mitchell, Andrew Lewandowski, Paula Delmore, Michael Cohen-Wolkowiez, Daniel Gonzalez
and on behalf of the Pediatric Trials Network Steering Committee
Open Access

Clinical Therapeutics
Efficacy and Tolerability Outcomes of a Phase II, Randomized, Open-Label, Multicenter Study of a New Water-Dispersible Pediatric Formulation of Dihydroartemisinin-Piperaquine for the Treatment of Uncomplicated Plasmodium falciparum Malaria in African Infants
Nicola Gargano, Lola Madrid, Giovanni Valentini, Umberto D'Alessandro, Tinto Halidou, Sodiomon Sirima, Antoinette Tshefu, Ali Mtoro, Samwel Gesase, The Eurartesim Dispersible Study Group, Quique Bassat
Open Access

Antiviral Agents
Safety, Tolerability, and Pharmacokinetics of MEDI8897, the Respiratory Syncytial Virus Prefusion F-Targeting Monoclonal Antibody with an Extended Half-Life, in Healthy Adults
M. Pamela Griffin, Anis A. Khan, Mark T. Esser, Kathryn Jensen, Therese Takas, Martin K. Kankam, Tonya Villafana, Filip Dubovsky

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