infection model
Experimental TherapeuticsAPX001 Is Effective in the Treatment of Murine Invasive Pulmonary AspergillosisInvasive pulmonary aspergillosis (IPA) due to Aspergillus fumigatus is a serious fungal infection in the immunosuppressed patient population. Despite the introduction of new antifungal agents, mortality rates remain high, and new treatments are needed.
- Experimental TherapeuticsIn Vitro and In Vivo Evaluation of APX001A/APX001 and Other Gwt1 Inhibitors against Cryptococcus
Cryptococcal meningitis (CM), caused primarily by Cryptococcus neoformans, is uniformly fatal if not treated. Treatment options are limited, especially in resource-poor geographical regions, and mortality rates remain high despite current therapies.
- Experimental TherapeuticsIn Vitro and In Vivo Evaluation of the Antifungal Activity of APX001A/APX001 against Candida auris