infective endocarditis

Experimental Therapeutics
Adjunctive Clavulanic Acid Abolishes the Cefazolin Inoculum Effect in an Experimental Rat Model of Methicillin-Sensitive Staphylococcus aureus Endocarditis
We tested the ability of clavulanic acid to restore the efficacy of cefazolin against Staphylococcus aureus TX0117, which exhibits the cefazolin inoculum effect (CzIE). In the rat infective endocarditis model, the coadministration of cefazolin plus clavulanic acid resulted in a significant reduction of bacterial counts (7.1 ± 0.5 log₁₀ CFU/g) compared to...

William R. Miller, Kavindra V. Singh, Cesar A. Arias, Barbara E. Murray
Clinical Therapeutics
Risk Factors and Outcomes of Endocarditis Due to Non-HACEK Gram-Negative Bacilli: Data from the Prospective Multicenter Italian Endocarditis Study Cohort
Marco Falcone, Giusy Tiseo, Emanuele Durante-Mangoni, Veronica Ravasio, Francesco Barbaro, Maria Paola Ursi, Maria Bruna Pasticci, Matteo Bassetti, Paolo Grossi, Mario Venditti, Marco Rizzi
Experimental Therapeutics
A Human Biofilm-Disrupting Monoclonal Antibody Potentiates Antibiotic Efficacy in Rodent Models of both Staphylococcus aureus and Acinetobacter baumannii Infections
Yan Q. Xiong, Angeles Estellés, L. Li, W. Abdelhady, R. Gonzales, Arnold S. Bayer, Edgar Tenorio, Anton Leighton, Stefan Ryser, Lawrence M. Kauvar
Experimental Therapeutics
Pharmacodynamics of Ceftaroline plus Ampicillin against Enterococcus faecalis in an In Vitro Pharmacokinetic/Pharmacodynamic Model of Simulated Endocardial Vegetations
Brian J. Werth, Laura M. Shireman
Clinical Therapeutics
Multicenter Observational Study of Ceftaroline Fosamil for Methicillin-Resistant Staphylococcus aureus Bloodstream Infections
Evan J. Zasowski, Trang D. Trinh, Kimberly C. Claeys, Anthony M. Casapao, Noor Sabagha, Abdalhamid M. Lagnf, Kenneth P. Klinker, Susan L. Davis, Michael J. Rybak
Experimental Therapeutics
Telavancin Is Active against Experimental Aortic Valve Endocarditis Caused by Daptomycin- and Methicillin-Resistant Staphylococcus aureus Strains
Wessam Abdelhady, Arnold S. Bayer, Rachelle Gonzales, Liang Li, Yan Q. Xiong

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infective endocarditis