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integrons

  • First Occurrence of the OXA-198 Carbapenemase in <em>Enterobacterales</em>
    Mechanisms of Resistance
    First Occurrence of the OXA-198 Carbapenemase in Enterobacterales

    A carbapenem-resistant Citrobacter sp. was recovered from routine screening of multidrug-resistant bacteria. This isolate coproduced OXA-48 and OXA-198. OXA-48 was carried by the prototypical IncL plasmid, whereas OXA-198 was carried by a peculiar IncHI-type plasmid. This carbapenemase gene was inserted within a class 1 integron located on a conjugative plasmid. This report describes the first occurrence of OXA-198 in ...

    Rémy A. Bonnin, Agnès B. Jousset, Lauraine Gauthier, Cécile Emeraud, Delphine Girlich, Aimie Sauvadet, Garance Cotellon, Thomas Jové, Laurent Dortet, Thierry Naas
  • Integron-Derived Aminoglycoside-Sensing Riboswitches Control Aminoglycoside Acetyltransferase Resistance Gene Expression
    Mechanisms of Resistance
    Integron-Derived Aminoglycoside-Sensing Riboswitches Control Aminoglycoside Acetyltransferase Resistance Gene Expression

    Class 1 integrons accumulate antibiotic resistance genes by site-specific recombination at aatI-1 sites. Captured genes are transcribed from a promoter located within the integron; for class 1 integrons, the first gene to be transcribed and translated normally encodes an aminoglycoside antibiotic resistance protein (either an acetyltransferase [AAC] or adenyltransferase [AAD]).

    Shasha Wang, Weizhi He, Wenxia Sun, Jun Zhang, Yaowen Chang, Dongrong Chen, Alastair I. H. Murchie
  • Mechanisms of Resistance
    PGI2 Is a Novel SGI1-Relative Multidrug-Resistant Genomic Island Characterized in Proteus mirabilis
    Chang-Wei Lei, Yan-Peng Chen, Ling-Han Kong, Jin-Xin Zeng, Yong-Xiang Wang, An-Yun Zhang, Hong-Ning Wang
  • Open Access
    Mechanisms of Resistance
    pSTM6-275, a Conjugative IncHI2 Plasmid of Salmonella enterica That Confers Antibiotic and Heavy-Metal Resistance under Changing Physiological Conditions
    Helen Billman-Jacobe, Yuhong Liu, Ruth Haites, Tom Weaver, Lily Robinson, Marc Marenda, Mike Dyall-Smith
  • Mechanisms of Resistance
    Expression of the aac(6′)-Ib-cr Gene in Class 1 Integrons
    Sophie Raherison, Thomas Jove, Margaux Gaschet, Emilie Pinault, Aurore Tabesse, Carmen Torres, Marie-Cécile Ploy
  • Mechanisms of Resistance
    Integron-Associated DfrB4, a Previously Uncharacterized Member of the Trimethoprim-Resistant Dihydrofolate Reductase B Family, Is a Clinically Identified Emergent Source of Antibiotic Resistance
    Jacynthe L. Toulouse, Thaddeus J. Edens, Lorea Alejaldre, Amee R. Manges, Joelle N. Pelletier
  • Mechanisms of Resistance
    Complete Nucleotide Sequences of Two VIM-1-Encoding Plasmids from Klebsiella pneumoniae and Leclercia adecarboxylata Isolates of Czech Origin
    Ivo Papousek, Costas C. Papagiannitsis, Matej Medvecky, Jaroslav Hrabak, Monika Dolejska
  • Mechanisms of Resistance
    attI1-Located Small Open Reading Frames ORF-17 and ORF-11 in a Class 1 Integron Affect Expression of a Gene Cassette Possessing a Canonical Shine-Dalgarno Sequence
    Costas C. Papagiannitsis, Leonidas S. Tzouvelekis, Eva Tzelepi, Vivi Miriagou
  • Mechanisms of Resistance
    qnrVC-Like Gene Located in a Novel Complex Class 1 Integron Harboring the ISCR1 Element in an Aeromonas punctata Strain from an Aquatic Environment in Shandong Province, China
    Ruirui Xia, Xianhu Guo, Yuzhen Zhang, Hai Xu
  • Mechanisms of Resistance
    Characterization of DIM-1, an Integron-Encoded Metallo-β-Lactamase from a Pseudomonas stutzeri Clinical Isolate in the Netherlands
    Laurent Poirel, Jose-Manuel Rodríguez-Martínez, Nashwan Al Naiemi, Yvette J. Debets-Ossenkopp, Patrice Nordmann

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