iron regulation
PharmacologyEfficacy of Humanized Cefiderocol Exposure Is Unaltered by Host Iron Overload in the Thigh Infection ModelCefiderocol is a siderophore-cephalosporin conjugate with greater in vitro potency under iron-depleted conditions. During infection, iron is scarce in host tissue; however, it is not known whether iron overload in the host, such as in cases of hereditary hemochromatosis, alters the efficacy of cefiderocol. We compared cefiderocol efficacy between iron-overloaded and standard murine thigh infection models.
PharmacologyDevelopment of Neutropenic Murine Models of Iron Overload and Depletion To Study the Efficacy of Siderophore-Antibiotic ConjugatesSiderophore-antibiotic conjugates have increased in vitro activity in low-iron environments where bacteria express siderophores and associated transporters. The host immune hypoferremic response reduces iron availability to bacteria; however, patients with iron overload or deficiency may have altered ability to restrict iron, which may affect the efficacy of siderophore-antibiotic conjugates. In vivo models of...
- Experimental TherapeuticsSynthetic Porcine Hepcidin Exhibits Different Roles in Escherichia coli and Salmonella Infections