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kinetics

  • Open Access
    Biochemical Characterization of QPX7728, a New Ultrabroad-Spectrum Beta-Lactamase Inhibitor of Serine and Metallo-Beta-Lactamases
    Editor's Pick Mechanisms of Resistance
    Biochemical Characterization of QPX7728, a New Ultrabroad-Spectrum Beta-Lactamase Inhibitor of Serine and Metallo-Beta-Lactamases

    QPX7728 is a new ultrabroad-spectrum inhibitor of serine and metallo-beta-lactamases (MBLs) from a class of cyclic boronates that gave rise to vaborbactam. The spectrum and mechanism of beta-lactamase inhibition by QPX7728 were assessed using purified enzymes from all molecular classes. QPX7728 inhibits class A extended-spectrum beta-lactamases (ESBLs) (50% inhibitory concentration [IC50] range, 1 to 3 nM) and carbapenemases...

    Ruslan Tsivkovski, Maxim Totrov, Olga Lomovskaya
  • Inhibition Activity of Avibactam against <span class="named-content genus-species" id="named-content-1">Nocardia farcinica</span> β-Lactamase FAR<sub>IFM10152</sub>
    Editor's Pick Mechanisms of Resistance
    Inhibition Activity of Avibactam against Nocardia farcinica β-Lactamase FARIFM10152

    Nocardia farcinica, one of the most frequent pathogenic species responsible for nocardiosis, is characterized by frequent brain involvement and resistance to β-lactams mediated by a class A β-lactamase. Kinetic parameters for hydrolysis of various β-lactams by FARIFM10152 from strain IFM 10152 were determined by spectrophotometry revealing a high catalytic...

    David Lebeaux, Clément Ourghanlian, Delphine Dorchène, Daria Soroka, Zainab Edoo, Fabrice Compain, Michel Arthur
  • Mechanisms of Resistance
    Kinetics of Sulbactam Hydrolysis by β-Lactamases, and Kinetics of β-Lactamase Inhibition by Sulbactam
    Adam B. Shapiro
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