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KPC

  • Carbapenemase-Producing Gram-Negative Bacteria from American Crows in the United States
    Epidemiology and Surveillance
    Carbapenemase-Producing Gram-Negative Bacteria from American Crows in the United States

    Wild corvids were examined for the presence of carbapenemase-producing Gram-negative bacteria in the United States. A total of 13 isolates were detected among 590 fecal samples of American crow; 11 Providencia rettgeri isolates harboring blaIMP-27 on the chromosome as a class 2 integron gene cassette within the Tn7 transposon, 1...

    Iva Kutilova, Adam Valcek, Costas C. Papagiannitsis, Darina Cejkova, Martina Masarikova, Veronika Paskova, Lenka Davidova-Gerzova, Petra Videnska, Jaroslav Hrabak, Ivan Literak, Monika Dolejska
  • KPC Beta-Lactamases Are Permissive to Insertions and Deletions Conferring Substrate Spectrum Modifications and Resistance to Ceftazidime-Avibactam
    Mechanisms of Resistance
    KPC Beta-Lactamases Are Permissive to Insertions and Deletions Conferring Substrate Spectrum Modifications and Resistance to Ceftazidime-Avibactam

    To explore the mutational possibilities of insertions and deletions (indels) in the Klebsiella pneumoniae carbapenemase (KPC) beta-lactamase, we selected for ceftazidime-avibactam-resistant mutants. Of 96 screened mutants, we obtained 19 indels (2 to 15 amino acids), all located in the loops surrounding the active site. Three antibiotic susceptibility phenotypes...

    Claire Amaris Hobson, Stéphane Bonacorsi, Hervé Jacquier, Alaksh Choudhury, Mélanie Magnan, Aurélie Cointe, Béatrice Bercot, Olivier Tenaillon, André Birgy
  • Resistance to Ceftazidime/Avibactam plus Meropenem/Vaborbactam When Both Are Used Together Is Achieved in Four Steps in Metallo-β-Lactamase-Negative <span class="named-content genus-species" id="named-content-1">Klebsiella pneumoniae</span>
    Mechanisms of Resistance
    Resistance to Ceftazidime/Avibactam plus Meropenem/Vaborbactam When Both Are Used Together Is Achieved in Four Steps in Metallo-β-Lactamase-Negative Klebsiella pneumoniae

    Serine β-lactamases are dominant causes of β-lactam resistance in Klebsiella pneumoniae isolates. Recently, this has driven clinical deployment of the β-lactam–β-lactamase inhibitor pairs ceftazidime/avibactam and meropenem/vaborbactam. We show that four steps, i.e., ompK36 and ramR mutation plus carriage of OXA-232 and KPC-3-D178Y variant β-...

    Punyawee Dulyayangkul, Edward J. A. Douglas, Filip Lastovka, Matthew B. Avison
  • Open Access
    Activity of Cefiderocol, Ceftazidime-Avibactam, and Eravacycline against Carbapenem-Resistant <span class="named-content genus-species" id="named-content-1">Escherichia coli</span> Isolates from the United States and International Sites in Relation to Clonal Background, Resistance Genes, Coresistance, and Region
    Epidemiology and Surveillance
    Activity of Cefiderocol, Ceftazidime-Avibactam, and Eravacycline against Carbapenem-Resistant Escherichia coli Isolates from the United States and International Sites in Relation to Clonal Background, Resistance Genes, Coresistance, and Region

    Emerging carbapenem resistance in Escherichia coli, including sequence type 131 (ST131), the leading cause of extraintestinal E. coli infections globally, threatens therapeutic efficacy. Accordingly, we determined broth microdilution MICs for three distinctive newer agents, i.e., cefiderocol (CFDC...

    Brian D. Johnston, Paul Thuras, Stephen B. Porter, Melissa Anacker, Brittany VonBank, Paula Snippes Vagnone, Medora Witwer, Mariana Castanheira, James R. Johnson
  • National Surveillance of Antimicrobial Susceptibility of Bacteremic Gram-Negative Bacteria with Emphasis on Community-Acquired Resistant Isolates: Report from the 2019 Surveillance of Multicenter Antimicrobial Resistance in Taiwan (SMART)
    Epidemiology and Surveillance
    National Surveillance of Antimicrobial Susceptibility of Bacteremic Gram-Negative Bacteria with Emphasis on Community-Acquired Resistant Isolates: Report from the 2019 Surveillance of Multicenter Antimicrobial Resistance in Taiwan (SMART)

    A multicenter collection of bacteremic isolates of Escherichia coli (n = 423), Klebsiella pneumoniae (n = 372), Pseudomonas aeruginosa (n = 300), and...

    Po-Yu Liu, Yu-Lin Lee, Min-Chi Lu, Pei-Lan Shao, Po-Liang Lu, Yen-Hsu Chen, Shu-Hsing Cheng, Wen-Chien Ko, Chi-Ying Lin, Ting-Shu Wu, Muh-Yong Yen, Lih-Shinn Wang, Chang-Pan Liu, Wen-Sen Lee, Yao-Shen Chen, Fu-Der Wang, Shu-Hui Tseng, Chao-Nan Lin, Hung-Jen Tang, Yu-Hui Chen, Wang-Huei Sheng, Chun-Ming Lee, Ming-Huei Liao, Po-Ren Hsueh
  • KPC-50 Confers Resistance to Ceftazidime-Avibactam Associated with Reduced Carbapenemase Activity
    Mechanisms of Resistance
    KPC-50 Confers Resistance to Ceftazidime-Avibactam Associated with Reduced Carbapenemase Activity

    KPC-50 is a KPC-3 variant identified from a Klebsiella pneumoniae clinical isolate recovered in Switzerland in 2019. Compared to KPC-3, KPC-50 shows (i) a three-amino-acid insertion (Glu-Ala-Val) between amino acids 276 and 277, (ii) an increased affinity to ceftazidime, (iii) a decreased sensitivity to avibactam, explaining the ceftazidime-avibactam resistance, and (...

    Laurent Poirel, Xavier Vuillemin, Mario Juhas, Amandine Masseron, Ursina Bechtel-Grosch, Simon Tiziani, Stefano Mancini, Patrice Nordmann
  • Impact of KPC Production and High-Level Meropenem Resistance on All-Cause Mortality of Ventilator-Associated Pneumonia in Association with <span class="named-content genus-species" id="named-content-1">Klebsiella pneumoniae</span>
    Clinical Therapeutics
    Impact of KPC Production and High-Level Meropenem Resistance on All-Cause Mortality of Ventilator-Associated Pneumonia in Association with Klebsiella pneumoniae

    Carbapenemase-producing Enterobacterales and specifically Klebsiella pneumoniae carbapenemase (KPC)-producing Klebsiella pneumoniae (KPC-Kp) are rapidly spreading worldwide. The prognosis of ventilator-associated pneumonia (VAP) caused by KPC-Kp is not well known. Our study tries to assess...

    Francisco Rivera-Espinar, Isabel Machuca, Rocio Tejero, Jorge Rodríguez, Ana Mula, Eduardo Marfil, Ángela Cano, Belén Gutiérrez-Gutiérrez, Marina Rodríguez, Juan Carlos Pozo, Carmen De la Fuente, Jesús Rodriguez-Baño, Luis Martínez-Martínez, Rafael León, Julian Torre-Cisneros
  • Genomic Epidemiology of Complex, Multispecies, Plasmid-Borne <em>bla</em><sub>KPC</sub> Carbapenemase in <em>Enterobacterales</em> in the United Kingdom from 2009 to 2014
    Epidemiology and Surveillance
    Genomic Epidemiology of Complex, Multispecies, Plasmid-Borne blaKPC Carbapenemase in Enterobacterales in the United Kingdom from 2009 to 2014

    Carbapenem resistance in Enterobacterales is a public health threat. Klebsiella pneumoniae carbapenemase (encoded by alleles of the blaKPC family) is one of the most common transmissible carbapenem resistance mechanisms worldwide. The dissemination of blaKPC historically has been associated with distinct...

    Nicole Stoesser, Hang T. T. Phan, Anna C. Seale, Zoie Aiken, Stephanie Thomas, Matthew Smith, David Wyllie, Ryan George, Robert Sebra, Amy J. Mathers, Alison Vaughan, Timothy E. A. Peto, Matthew J. Ellington, Katie L. Hopkins, Derrick W. Crook, Alex Orlek, William Welfare, Julie Cawthorne, Cheryl Lenney, Andrew Dodgson, Neil Woodford, A. Sarah Walker, the TRACE Investigators’ Group
  • Ceftazidime-Avibactam Resistance Associated with Increased <em>bla</em><sub>KPC-3</sub> Gene Copy Number Mediated by pKpQIL Plasmid Derivatives in Sequence Type 258 <em>Klebsiella pneumoniae</em>
    Mechanisms of Resistance
    Ceftazidime-Avibactam Resistance Associated with Increased blaKPC-3 Gene Copy Number Mediated by pKpQIL Plasmid Derivatives in Sequence Type 258 Klebsiella pneumoniae

    This study reports on the characterization of two ceftazidime-avibactam (CZA)-resistant KPC-producing Klebsiella pneumoniae strains (KP-14159 and KP-8788) sequentially isolated from infections occurred in a patient never treated with CZA. Whole-genome sequencing characterization using a combined short- and long-read sequencing approach showed that both isolates...

    Marco Coppi, Vincenzo Di Pilato, Francesco Monaco, Tommaso Giani, Pier Giulio Conaldi, Gian Maria Rossolini
  • Improvement of the Immunochromatographic NG-Test Carba 5 Assay for the Detection of IMP Variants Previously Undetected
    Mechanisms of Resistance
    Improvement of the Immunochromatographic NG-Test Carba 5 Assay for the Detection of IMP Variants Previously Undetected

    Here, we evaluated the immunochromatographic assay NG-Test Carba 5v2 (NG-Biotech), with improved IMP variant detection on 31 IMP producers, representing the different branches of the IMP phylogeny, including 32 OXA-48, 19 KPC, 12 VIM, 14 NDM, and 13 multiple carbapenemase producers (CPs), 13 CPs that were not targeted, and 13 carbapenemase-negative isolates. All tested IMP variants were accurately detected without impairing detection of...

    Hervé Volland, Delphine Girlich, Marine Laguide, Camille Gonzalez, Virginie Paris, Maxime Laroche, Saoussen Oueslati, Laurent Dortet, Stéphanie Simon, Thierry Naas

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