Lactams

Mechanisms of Resistance
Structural Insights into the TLA-3 Extended-Spectrum β-Lactamase and Its Inhibition by Avibactam and OP0595
Wanchun Jin, Jun-ichi Wachino, Yoshihiro Yamaguchi, Kouji Kimura, Anupriya Kumar, Mototsugu Yamada, Akihiro Morinaka, Yoshiaki Sakamaki, Minoru Yonezawa, Hiromasa Kurosaki, Yoshichika Arakawa
Experimental Therapeutics
Efficacy and Pharmacokinetics of the Combination of OP0595 and Cefepime in a Mouse Model of Pneumonia Caused by Extended-Spectrum-Beta-Lactamase-Producing Klebsiella pneumoniae
Norihito Kaku, Kosuke Kosai, Kazuaki Takeda, Naoki Uno, Yoshitomo Morinaga, Hiroo Hasegawa, Taiga Miyazaki, Koichi Izumikawa, Hiroshi Mukae, Katsunori Yanagihara
Susceptibility
Comparative Antipneumococcal Activities of Sulopenem and Other Drugs
Klaudia Kosowska-Shick, Lois M. Ednie, Pamela McGhee, Peter C. Appelbaum
Susceptibility
Antianaerobic Activity of Sulopenem Compared to Six Other Agents
Lois M. Ednie, Peter C. Appelbaum
Susceptibility
Efficacy of Piperacillin Combined with the Penem β-Lactamase Inhibitor BLI-489 in Murine Models of Systemic Infection
Peter J. Petersen, C. Hal Jones, Aranapakam M. Venkatesan, Patricia A. Bradford
Clinical Therapeutics
Acquisition of Resistant Bowel Flora during a Double-Blind Randomized Clinical Trial of Ertapenem versus Piperacillin-Tazobactam Therapy for Intraabdominal Infections
Mark J. DiNubile, Joseph W. Chow, Vilas Satishchandran, Adam Polis, Mary R. Motyl, Murray A. Abramson, Hedy Teppler
Antiviral Agents
Development of Cell-Based Assays for In Vitro Characterization of Hepatitis C Virus NS3/4A Protease Inhibitors
Victoria Chung, Anthony R. Carroll, Norman M. Gray, Nigel R. Parry, Pia A. Thommes, K. Claire Viner, Eric A. D'Souza
Experimental Therapeutics
Pharmacodynamic Profile of Ertapenem against Klebsiella pneumoniae and Escherichia coli in a Murine Thigh Model
Dana Maglio, Mary Anne Banevicius, Christina Sutherland, Chinedum Babalola, Charles H. Nightingale, David P. Nicolau
Experimental Therapeutics
Pharmacodynamics of Ceftazidime plus the Serine β-Lactamase Inhibitor AM-112 against Escherichia coli Containing TEM-1 and CTX-M-1 β-Lactamases
Karen E. Bowker, Alan R. Noel, Timothy R. Walsh, Chris A. Rogers, Alasdair P. MacGowan
Pharmacology
Ertapenem Pharmacokinetics and Impact on Intestinal Microflora, in Comparison to Those of Ceftriaxone, after Multiple Dosing in Male and Female Volunteers
Mathias W. R. Pletz, Mareike Rau, Juergen Bulitta, Andres De Roux, Olaf Burkhardt, Guido Kruse, Michael Kurowski, Carl E. Nord, Hartmut Lode

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