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Lactams

  • Mechanisms of Resistance
    Structural Insights into the TLA-3 Extended-Spectrum β-Lactamase and Its Inhibition by Avibactam and OP0595
    Wanchun Jin, Jun-ichi Wachino, Yoshihiro Yamaguchi, Kouji Kimura, Anupriya Kumar, Mototsugu Yamada, Akihiro Morinaka, Yoshiaki Sakamaki, Minoru Yonezawa, Hiromasa Kurosaki, Yoshichika Arakawa
  • Experimental Therapeutics
    Efficacy and Pharmacokinetics of the Combination of OP0595 and Cefepime in a Mouse Model of Pneumonia Caused by Extended-Spectrum-Beta-Lactamase-Producing Klebsiella pneumoniae
    Norihito Kaku, Kosuke Kosai, Kazuaki Takeda, Naoki Uno, Yoshitomo Morinaga, Hiroo Hasegawa, Taiga Miyazaki, Koichi Izumikawa, Hiroshi Mukae, Katsunori Yanagihara
  • Susceptibility
    Comparative Antipneumococcal Activities of Sulopenem and Other Drugs
    Klaudia Kosowska-Shick, Lois M. Ednie, Pamela McGhee, Peter C. Appelbaum
  • Susceptibility
    Antianaerobic Activity of Sulopenem Compared to Six Other Agents
    Lois M. Ednie, Peter C. Appelbaum
  • Susceptibility
    Efficacy of Piperacillin Combined with the Penem β-Lactamase Inhibitor BLI-489 in Murine Models of Systemic Infection
    Peter J. Petersen, C. Hal Jones, Aranapakam M. Venkatesan, Patricia A. Bradford
  • Clinical Therapeutics
    Acquisition of Resistant Bowel Flora during a Double-Blind Randomized Clinical Trial of Ertapenem versus Piperacillin-Tazobactam Therapy for Intraabdominal Infections
    Mark J. DiNubile, Joseph W. Chow, Vilas Satishchandran, Adam Polis, Mary R. Motyl, Murray A. Abramson, Hedy Teppler
  • Antiviral Agents
    Development of Cell-Based Assays for In Vitro Characterization of Hepatitis C Virus NS3/4A Protease Inhibitors
    Victoria Chung, Anthony R. Carroll, Norman M. Gray, Nigel R. Parry, Pia A. Thommes, K. Claire Viner, Eric A. D'Souza
  • Experimental Therapeutics
    Pharmacodynamic Profile of Ertapenem against Klebsiella pneumoniae and Escherichia coli in a Murine Thigh Model
    Dana Maglio, Mary Anne Banevicius, Christina Sutherland, Chinedum Babalola, Charles H. Nightingale, David P. Nicolau
  • Experimental Therapeutics
    Pharmacodynamics of Ceftazidime plus the Serine β-Lactamase Inhibitor AM-112 against Escherichia coli Containing TEM-1 and CTX-M-1 β-Lactamases
    Karen E. Bowker, Alan R. Noel, Timothy R. Walsh, Chris A. Rogers, Alasdair P. MacGowan
  • Pharmacology
    Ertapenem Pharmacokinetics and Impact on Intestinal Microflora, in Comparison to Those of Ceftriaxone, after Multiple Dosing in Male and Female Volunteers
    Mathias W. R. Pletz, Mareike Rau, Juergen Bulitta, Andres De Roux, Olaf Burkhardt, Guido Kruse, Michael Kurowski, Carl E. Nord, Hartmut Lode

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