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lanosterol 14α-demethylase

  • Crystal Structures of Full-Length Lanosterol 14α-Demethylases of Prominent Fungal Pathogens <span class="named-content genus-species" id="named-content-1">Candida albicans</span> and <span class="named-content genus-species" id="named-content-2">Candida glabrata</span> Provide Tools for Antifungal Discovery
    Mechanisms of Action: Physiological Effects
    Crystal Structures of Full-Length Lanosterol 14α-Demethylases of Prominent Fungal Pathogens Candida albicans and Candida glabrata Provide Tools for Antifungal Discovery

    Targeting lanosterol 14α-demethylase (LDM) with azole drugs provides prophylaxis and treatments for superficial and disseminated fungal infections, but cure rates are not optimal for immunocompromised patients and individuals with comorbidities. The efficacy of azole drugs has also been reduced due to the emergence of drug-resistant fungal pathogens.

    Mikhail V. Keniya, Manya Sabherwal, Rajni K. Wilson, Matthew A. Woods, Alia A. Sagatova, Joel D. A. Tyndall, Brian C. Monk
  • Heterologous Expression of Full-Length Lanosterol 14α-Demethylases of Prominent Fungal Pathogens <span class="named-content genus-species" id="named-content-1">Candida albicans</span> and <span class="named-content genus-species" id="named-content-2">Candida glabrata</span> Provides Tools for Antifungal Discovery
    Mechanisms of Action: Physiological Effects
    Heterologous Expression of Full-Length Lanosterol 14α-Demethylases of Prominent Fungal Pathogens Candida albicans and Candida glabrata Provides Tools for Antifungal Discovery

    Targeting lanosterol 14α-demethylase (LDM) with azole drugs provides prophylaxis and treatments for superficial and disseminated fungal infections, but cure rates are modest for immunocompromised patients and individuals with comorbidities. The efficacy of azole drugs has also been reduced due to the emergence of drug-resistant fungal pathogens.

    Mikhail V. Keniya, Yasmeen N. Ruma, Joel D. A. Tyndall, Brian C. Monk
  • Mechanisms of Resistance
    Impact of Homologous Resistance Mutations from Pathogenic Yeast on Saccharomyces cerevisiae Lanosterol 14α-Demethylase
    Alia A. Sagatova, Mikhail V. Keniya, Joel D. A. Tyndall, Brian C. Monk
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