latent infection

  • Deletion of <em>pknG</em> Abates Reactivation of Latent <span class="named-content genus-species" id="named-content-1">Mycobacterium tuberculosis</span> in Mice
    Experimental Therapeutics
    Deletion of pknG Abates Reactivation of Latent Mycobacterium tuberculosis in Mice

    Eradication of tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), has been a challenge due to its uncanny ability to survive in a dormant state inside host granulomas for decades. Mtb rewires its metabolic and redox regulatory networks to survive in the hostile hypoxic and nutrient-limiting environment, facilitating the formation of drug-...

    Mehak Zahoor Khan, Vinay Kumar Nandicoori
  • Open Access
    Chloroquine Potentiates Primaquine Activity against Active and Latent Hepatic Plasmodia <em>Ex Vivo</em>: Potentials and Pitfalls
    Experimental Therapeutics
    Chloroquine Potentiates Primaquine Activity against Active and Latent Hepatic Plasmodia Ex Vivo: Potentials and Pitfalls

    For a long while, 8-aminoquinoline compounds have been the only therapeutic agents against latent hepatic malaria parasites. These have poor activity against the blood-stage plasmodia causing acute malaria and must be used in conjunction with partner blood schizontocidal agents. We examined the impacts of one such agent, chloroquine, upon the activity of primaquine, an 8-aminoquinoline, against hepatic stages of...

    Laurent Dembélé, Jean-François Franetich, Valérie Soulard, Nadia Amanzougaghene, Shahin Tajeri, Teun Bousema, Geert-Jan van Gemert, Roger Le Grand, Nathalie Dereuddre-Bosquet, J. Kevin Baird, Dominique Mazier, Georges Snounou
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