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Leishmania mexicana

  • Open Access
    Activity of Chitosan and Its Derivatives against <span class="named-content genus-species" id="named-content-1">Leishmania major</span> and <span class="named-content genus-species" id="named-content-2">Leishmania mexicana</span> <em>In Vitro</em>
    Experimental Therapeutics
    Activity of Chitosan and Its Derivatives against Leishmania major and Leishmania mexicana In Vitro

    There is an urgent need for safe, efficacious, affordable, and field-adapted drugs for the treatment of cutaneous leishmaniasis, which newly affects around 1.5 million people worldwide annually. Chitosan, a biodegradable cationic polysaccharide, has previously been reported to have antimicrobial, antileishmanial, and immunostimulatory activities.

    Alaa Riezk, John G. Raynes, Vanessa Yardley, Sudaxshina Murdan, Simon L. Croft
  • Open Access
    Clinical Therapeutics
    Efficacy of a Binuclear Cyclopalladated Compound Therapy for Cutaneous Leishmaniasis in the Murine Model of Infection with Leishmania amazonensis and Its Inhibitory Effect on Topoisomerase 1B
    Angela Maria Arenas Velásquez, Willian Campos Ribeiro, Vutey Venn, Silvia Castelli, Mariana Santoro de Camargo, Renata Pires de Assis, Rodrigo Alves de Souza, Aline Rimoldi Ribeiro, Thaís Gaban Passalacqua, João Aristeu da Rosa, Amanda Martins Baviera, Antonio Eduardo Mauro, Alessandro Desideri, Elmo Eduardo Almeida-Amaral, Marcia A. S. Graminha
  • Open Access
    Experimental Therapeutics
    Efficacy of Paromomycin-Chloroquine Combination Therapy in Experimental Cutaneous Leishmaniasis
    Gert-Jan Wijnant, Katrien Van Bocxlaer, Vanessa Yardley, Sudaxshina Murdan, Simon L. Croft
  • Mechanisms of Action: Physiological Effects
    Perifosine Mechanisms of Action in Leishmania Species
    Atteneri López-Arencibia, Carmen Martín-Navarro, Ines Sifaoui, María Reyes-Batlle, Carolina Wagner, Jacob Lorenzo-Morales, Sutherland K. Maciver, José E. Piñero
  • Mechanisms of Action: Physiological Effects
    Amiodarone Destabilizes Intracellular Ca2+ Homeostasis and Biosynthesis of Sterols in Leishmania mexicana
    Xenón Serrano-Martín, Yael García-Marchan, Alexis Fernandez, Noris Rodriguez, Hector Rojas, Gonzalo Visbal, Gustavo Benaim
  • Experimental Therapeutics
    Antileishmanial Activity of 1,3,4-Thiadiazolium-2-Aminide in Mice Infected with Leishmania amazonensis
    Raquel F. Rodrigues, Karen S. Charret, Edson F. da Silva, Áurea Echevarria, Verônica F. Amaral, Leonor L. Leon, Marilene M. Canto-Cavalheiro
  • Susceptibility
    In Vitro Activities of ER-119884 and E5700, Two Potent Squalene Synthase Inhibitors, against Leishmania amazonensis: Antiproliferative, Biochemical, and Ultrastructural Effects
    Juliany Cola Fernandes Rodrigues, Juan Luis Concepcion, Carlos Rodrigues, Aura Caldera, Julio A. Urbina, Wanderley de Souza
  • Susceptibility
    Activity of Hydroxyurea against Leishmania mexicana
    Hugo Martinez-Rojano, Javier Mancilla-Ramirez, Laura Quiñonez-Diaz, Norma Galindo-Sevilla
  • Experimental Therapeutics
    Glibenclamide, a Blocker of K+ATP Channels, Shows Antileishmanial Activity in Experimental Murine Cutaneous Leishmaniasis
    Xenón Serrano-Martín, Gilberto Payares, Alexis Mendoza-León
  • Susceptibility
    Photodynamic Sensitization of Leishmania amazonensis in both Extracellular and Intracellular Stages with Aluminum Phthalocyanine Chloride for Photolysis In Vitro
    Sujoy Dutta, Debalina Ray, Bala K. Kolli, Kwang-Poo Chang

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