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lipopolysaccharide

  • Preserving Vascular Integrity Protects Mice against Multidrug-Resistant Gram-Negative Bacterial Infection
    Editor's Pick Experimental Therapeutics
    Preserving Vascular Integrity Protects Mice against Multidrug-Resistant Gram-Negative Bacterial Infection

    The rise in multidrug-resistant (MDR) organisms portends a serious global threat to the health care system with nearly untreatable infectious diseases, including pneumonia and its often fatal sequelae, acute respiratory distress syndrome (ARDS) and sepsis. Gram-negative bacteria (GNB), including Acinetobacter baumannii,...

    Teclegiorgis Gebremariam, Lina Zhang, Sondus Alkhazraji, Yiyou Gu, Eman G. Youssef, Zongzhong Tong, Erik Kish-Trier, Ashok Bajji, Claudia V. de Araujo, Bianca Rich, Samuel W. French, Dean Y. Li, Alan L. Mueller, Shannon J. Odelberg, Weiquan Zhu, Ashraf S. Ibrahim
  • Levonadifloxacin, a Novel Benzoquinolizine Fluoroquinolone, Modulates Lipopolysaccharide-Induced Inflammatory Responses in Human Whole-Blood Assay and Murine Acute Lung Injury Model
    Pharmacology
    Levonadifloxacin, a Novel Benzoquinolizine Fluoroquinolone, Modulates Lipopolysaccharide-Induced Inflammatory Responses in Human Whole-Blood Assay and Murine Acute Lung Injury Model

    Fluoroquinolones are reported to possess immunomodulatory activity; hence, a novel benzoquinolizine fluoroquinolone, levonadifloxacin, was evaluated in lipopolysaccharide-stimulated human whole-blood (HWB) and mouse acute lung injury (ALI) models. Levonadifloxacin significantly mitigated the inflammatory responses in an HWB assay through inhibition of proinflammatory cytokines and in the ALI model by lowering lung total white blood cell...

    Anasuya Patel, Ganesh V. Sangle, Jinal Trivedi, Sushant A. Shengule, Deepak Thorve, Mohan Patil, Nitin J. Deshmukh, Bhushan Choudhari, Avinash Karade, Sangita Gupta, Sachin Bhagwat, Mahesh Patel
  • Antibody Binding to the O-Specific Antigen of <span class="named-content genus-species" id="named-content-1">Pseudomonas aeruginosa</span> O6 Inhibits Cell Growth
    Experimental Therapeutics
    Antibody Binding to the O-Specific Antigen of Pseudomonas aeruginosa O6 Inhibits Cell Growth

    Pseudomonas aeruginosa is an opportunistic pathogen that is inherently resistant to many antibiotics and represents an increasing threat due to the emergence of drug-resistant strains. There is a pressing need to develop innovative antimicrobials against this pathogen. In this study, we identified the O-specific antigen (OSA) of...

    Gabrielle Richard, C. Roger MacKenzie, Kevin A. Henry, Evgeny Vinogradov, J. Christopher Hall, Greg Hussack
  • A Whole-Cell Screen Identifies Small Bioactives That Synergize with Polymyxin and Exhibit Antimicrobial Activities against Multidrug-Resistant Bacteria
    Susceptibility
    A Whole-Cell Screen Identifies Small Bioactives That Synergize with Polymyxin and Exhibit Antimicrobial Activities against Multidrug-Resistant Bacteria

    The threat of diminished antibiotic discovery has global health care in crisis. In the United States, it is estimated each year that over 2 million bacterial infections are resistant to first-line antibiotic treatments and cost in excess of 20 billion dollars.

    Shawn M. Zimmerman, Audrey-Ann J. Lafontaine, Carmen M. Herrera, Amanda B. Mclean, M. Stephen Trent
  • Open Access
    Derepression of the <em>smvA</em> Efflux System Arises in Clinical Isolates of <span class="named-content genus-species" id="named-content-1">Proteus mirabilis</span> and Reduces Susceptibility to Chlorhexidine and Other Biocides
    Susceptibility
    Derepression of the smvA Efflux System Arises in Clinical Isolates of Proteus mirabilis and Reduces Susceptibility to Chlorhexidine and Other Biocides

    Proteus mirabilis is a common pathogen of the catheterized urinary tract and often described as intrinsically resistant to the biocide chlorhexidine (CHD). Here, we demonstrate that derepression of the smvA efflux system has occurred in clinical isolates of P. mirabilis and reduces...

    H. Pelling, L. J. Bock, J. Nzakizwanayo, M. E. Wand, E. L. Denham, W. M. MacFarlane, J. M. Sutton, B. V. Jones
  • Disrupting Gram-Negative Bacterial Outer Membrane Biosynthesis through Inhibition of the Lipopolysaccharide Transporter MsbA
    Experimental Therapeutics
    Disrupting Gram-Negative Bacterial Outer Membrane Biosynthesis through Inhibition of the Lipopolysaccharide Transporter MsbA

    There is a critical need for new antibacterial strategies to counter the growing problem of antibiotic resistance. In Gram-negative bacteria, the outer membrane (OM) provides a protective barrier against antibiotics and other environmental insults.

    Mary Kate Alexander, Anh Miu, Angela Oh, Mike Reichelt, Hoangdung Ho, Cecile Chalouni, Sharada Labadie, Lan Wang, Jun Liang, Nicholas N. Nickerson, Huiyong Hu, Lan Yu, Miaofen Du, Donghong Yan, Summer Park, Janice Kim, Min Xu, Benjamin D. Sellers, Hans E. Purkey, Nicholas J. Skelton, Michael F. T. Koehler, Jian Payandeh, Vishal Verma, Yiming Xu, Christopher M. Koth, Mireille Nishiyama
  • Open Access
    Mechanisms of Action: Physiological Effects
    Combined Systems Approaches Reveal a Multistage Mode of Action of a Marine Antimicrobial Peptide against Pathogenic Escherichia coli and Its Protective Effect against Bacterial Peritonitis and Endotoxemia
    Xiumin Wang, Da Teng, Ruoyu Mao, Na Yang, Ya Hao, Jianhua Wang
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