Malaria, Falciparum

Mechanisms of Resistance
Changing Antimalarial Drug Sensitivities in Uganda
Stephanie A. Rasmussen, Frida G. Ceja, Melissa D. Conrad, Patrick K. Tumwebaze, Oswald Byaruhanga, Thomas Katairo, Samuel L. Nsobya, Philip J. Rosenthal, Roland A. Cooper
Epidemiology and Surveillance
K13 Propeller Alleles, mdr1 Polymorphism, and Drug Effectiveness at Day 3 after Artemether-Lumefantrine Treatment for Plasmodium falciparum Malaria in Colombia, 2014-2015
Madeline Montenegro, Aaron T. Neal, Maritza Posada, Briegel De las Salas, Tatiana M. Lopera-Mesa, Rick M. Fairhurst, Alberto Tobon-Castaño
Open Access

Epidemiology and Surveillance
Sustained Ex Vivo Susceptibility of Plasmodium falciparum to Artemisinin Derivatives but Increasing Tolerance to Artemisinin Combination Therapy Partner Quinolines in The Gambia
Alfred Amambua-Ngwa, Joseph Okebe, Haddijatou Mbye, Sukai Ceesay, Fatima El-Fatouri, Fatou Joof, Haddy Nyang, Ramatoulie Janha, Muna Affara, Abdullahi Ahmad, Olimatou Kolly, Davis Nwakanma, Umberto D'Alessandro
Open Access

Mechanisms of Action: Physiological Effects
A Dynamic Stress Model Explains the Delayed Drug Effect in Artemisinin Treatment of Plasmodium falciparum
Pengxing Cao, Nectarios Klonis, Sophie Zaloumis, Con Dogovski, Stanley C. Xie, Sompob Saralamba, Lisa J. White, Freya J. I. Fowkes, Leann Tilley, Julie A. Simpson, James M. McCaw
Experimental Therapeutics
Assessment of Clinical Pharmacokinetic Drug-Drug Interaction of Antimalarial Drugs α/β-Arteether and Sulfadoxine-Pyrimethamine
Y. S. Chhonker, V. V. Bhosale, S. K. Sonkar, H. Chandasana, D. Kumar, S. Vaish, S. C. Choudhary, S. Bhadhuria, S. Sharma, R. K. Singh, G. K. Jain, A. K. Vaish, S. P. S. Gaur, R. S. Bhatta
Open Access

Susceptibility
Plasmodium falciparum and Plasmodium vivax Demonstrate Contrasting Chloroquine Resistance Reversal Phenotypes
Grennady Wirjanata, Irene Handayuni, Pak Prayoga, Leo Leonardo, Dwi Apriyanti, Leily Trianty, Ruland Wandosa, Basbak Gobay, Enny Kenangalem, Jeanne Rini Poespoprodjo, Rintis Noviyanti, Dennis E. Kyle, Qin Cheng, Ric N. Price, Jutta Marfurt
Open Access

Pharmacology
Age, Weight, and CYP2D6 Genotype Are Major Determinants of Primaquine Pharmacokinetics in African Children
Bronner P. Gonçalves, Helmi Pett, Alfred B. Tiono, Daryl Murry, Sodiomon B. Sirima, Mikko Niemi, Teun Bousema, Chris Drakeley, Rob ter Heine
Open Access

Pharmacology
Prediction of Improved Antimalarial Chemoprevention with Weekly Dosing of Dihydroartemisinin-Piperaquine
Jesmin Permala, Joel Tarning, François Nosten, Nicholas J. White, Mats O. Karlsson, Martin Bergstrand
Open Access

Experimental Therapeutics
Simplified Reversed Chloroquines To Overcome Malaria Resistance to Quinoline-Based Drugs
Bornface Gunsaru, Steven J. Burgess, Westin Morrill, Jane X. Kelly, Shawheen Shomloo, Martin J. Smilkstein, Katherine Liebman, David H. Peyton
Pharmacology
Piperaquine Population Pharmacokinetics and Cardiac Safety in Cambodia
Pattaraporn Vanachayangkul, Chanthap Lon, Michele Spring, Sommethy Sok, Winita Ta-aksorn, Chanikarn Kodchakorn, Sut-Thang Pann, Soklyda Chann, Mali Ittiverakul, Sabaithip Sriwichai, Nillawan Buathong, Worachet Kuntawunginn, Mary So, Theng Youdaline, Erin Milner, Mariusz Wojnarski, Charlotte Lanteri, Jessica Manning, Satharath Prom, Mark Haigney, Louis Cantilena, David Saunders

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Malaria, Falciparum

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