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MDR-TB

  • Correlation of Linezolid Hair Concentrations with Plasma Exposure in Patients with Drug-Resistant Tuberculosis
    Letter to the Editor
    Correlation of Linezolid Hair Concentrations with Plasma Exposure in Patients with Drug-Resistant Tuberculosis
    Sean Wasserman, Shu Huo, Karina Ky, Ysabella Noelle Malig, Ali Esmail, Keertan Dheda, Peter Bacchetti, Roy Gerona, Gary Maartens, Monica Gandhi, John Metcalfe
  • Open Access
    Fluoroquinolone Efficacy against Tuberculosis Is Driven by Penetration into Lesions and Activity against Resident Bacterial Populations
    Editor's Pick Pharmacology
    Fluoroquinolone Efficacy against Tuberculosis Is Driven by Penetration into Lesions and Activity against Resident Bacterial Populations

    Fluoroquinolones represent the pillar of multidrug-resistant tuberculosis (MDR-TB) treatment, with moxifloxacin, levofloxacin, or gatifloxacin being prescribed to MDR-TB patients. Recently, several clinical trials of “universal” drug regimens, aiming to treat drug-susceptible and drug-resistant TB, have included a fluoroquinolone.

    Jansy Sarathy, Landry Blanc, Nadine Alvarez-Cabrera, Paul O’Brien, Isabela Dias-Freedman, Marizel Mina, Matthew Zimmerman, Firat Kaya, Hsin-Pin Ho Liang, Brendan Prideaux, Jillian Dietzold, Padmini Salgame, Radojka M. Savic, Jennifer Linderman, Denise Kirschner, Elsje Pienaar, Véronique Dartois
  • Chemistry; Biosynthesis
    Metabolism of SKLB-TB1001, a Potent Antituberculosis Agent, in Animals
    Lu Xiong, Chao Gao, Yao-Jie Shi, Xin Tao, Cui-Ting Peng, Juan Rong, Kun-Lin Liu, Qian Lei, Yi-Wen Zhang, Ning-Yu Wang, Luo-Ting Yu
  • Pharmacology
    Pharmacokinetics of Second-Line Antituberculosis Drugs in Children with Multidrug-Resistant Tuberculosis in India
    Agibothu Kupparam Hemanth Kumar, Alok Kumar, Thiruvengadam Kannan, Rakesh Bhatia, Dipti Agarwal, Santosh Kumar, Rajeshwar Dayal, Sheo Pratap Singh, Geetha Ramachandran
  • Letter to the Editor
    Pyrazinamide Resistance among Multidrug-Resistant Mycobacterium tuberculosis Clinical Isolates in Myanmar
    Wah Wah Aung, Phyu Win Ei, Wint Wint Nyunt, Mi Mi Htwe, Su Mon Win, Kay Thi Aye, Aye Su Mon, Si Thu Aung, Chulhun L. Chang, Jong Seok Lee
  • Pharmacology
    Sterilizing Effect of Ertapenem-Clavulanate in a Hollow-Fiber Model of Tuberculosis and Implications on Clinical Dosing
    Sander P. van Rijn, Shashikant Srivastava, Mireille A. Wessels, Dick van Soolingen, Jan-Willem C. Alffenaar, Tawanda Gumbo
  • Open Access
    Susceptibility
    Pyrazinamide Susceptibility and pncA Mutation Profiles of Mycobacterium tuberculosis among Multidrug-Resistant Tuberculosis Patients in Bangladesh
    Arfatur Rahman, Sara Sabrina Ferdous, Shahriar Ahmed, S. M. Mazidur Rahman, Mohammad Khaja Mafij Uddin, Suporn Pholwat, Jean Gratz, Eric Houpt, Sayera Banu
  • Pharmacology
    Pharmacokinetics of Levofloxacin in Multidrug- and Extensively Drug-Resistant Tuberculosis Patients
    Natasha van't Boveneind-Vrubleuskaya, Tatiana Seuruk, Kai van Hateren, Tridia van der Laan, Jos G. W. Kosterink, Tjip S. van der Werf, Dick van Soolingen, Susan van den Hof, Alena Skrahina, Jan-Willem C. Alffenaar
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