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meningitis

  • Open Access
    Cerebrospinal Fluid Penetration of Ceftolozane-Tazobactam in Critically Ill Patients with an Indwelling External Ventricular Drain
    Clinical Therapeutics
    Cerebrospinal Fluid Penetration of Ceftolozane-Tazobactam in Critically Ill Patients with an Indwelling External Ventricular Drain

    The aim of this study was to describe the pharmacokinetics of ceftolozane-tazobactam in plasma and cerebrospinal fluid (CSF) of infected critically ill patients. In a prospective observational study, critically ill patients (≥18 years) with an indwelling external ventricular drain received a single intravenous dose of 3.0 g ceftolozane-tazobactam. Serial plasma and CSF samples were collected for measurement of unbound ceftolozane and...

    Fekade B. Sime, Melissa Lassig-Smith, Therese Starr, Janine Stuart, Saurabh Pandey, Suzanne L. Parker, Steven C. Wallis, Jeffrey Lipman, Jason A. Roberts
  • Free
    Emergence of Ceftriaxone Resistance during a Case of Pneumococcal Meningitis with Fatal Evolution
    Editor's Pick Challenging Clinical Case in Antimicrobial Resistance
    Emergence of Ceftriaxone Resistance during a Case of Pneumococcal Meningitis with Fatal Evolution

    We report a case of a 62-year-old man treated for Streptococcus pneumoniae meningitis by ceftriaxone and dexamethasone. After neurological improvement, neurological degradation by vasculitis occurred, despite effective concentrations of ceftriaxone in the serum and cerebrospinal fluid (CSF). S. pneumoniae...

    A. Mizrahi, J. C. Marvaud, B. Pilmis, J. C. Nguyen Van, C. Couzigou, C. Bruel, N. Engrand, A. Le Monnier, T. Lambert
  • Free
    Case Commentary: Delayed Cerebral Vasculitis Associated with the Development of Ceftriaxone-Resistant Pneumococcal Meningitis
    Editor's Pick Challenging Clinical Case in Antimicrobial Resistance
    Case Commentary: Delayed Cerebral Vasculitis Associated with the Development of Ceftriaxone-Resistant Pneumococcal Meningitis

    Mizrahi and colleagues present a well-described case of the emergence of drug resistance in Streptococcus pneumoniae meningitis during therapy with ceftriaxone monotherapy with a low bactericidal concentration in the cerebrospinal fluid. Adherence to international guidelines could possibly have prevented the emergence of this resistant isolate and the adverse outcome...

    Rodrigo Hasbun
  • Delamanid Central Nervous System Pharmacokinetics in Tuberculous Meningitis in Rabbits and Humans
    Experimental Therapeutics
    Delamanid Central Nervous System Pharmacokinetics in Tuberculous Meningitis in Rabbits and Humans

    Central nervous system tuberculosis (TB) is devastating and affects vulnerable populations. Multidrug-resistant (MDR) and extensively drug-resistant (XDR) tuberculous meningitis (TBM) specifically are nearly uniformly fatal, with little information being available to guide the treatment of these patients. Delamanid (DLM), a nitro-dihydro-imidazooxazole, is a new, well-tolerated anti-TB drug with a low MIC (1 to 12 ng/ml) against...

    Elizabeth W. Tucker, Lisa Pieterse, Matthew D. Zimmerman, Zarir F. Udwadia, Charles A. Peloquin, Maria Tarcela Gler, Shashank Ganatra, Jeffrey A. Tornheim, Prerna Chawla, Janice C. Caoili, Brittaney Ritchie, Sanjay K. Jain, Véronique Dartois, Kelly E. Dooley
  • Plasmid Carrying <em>bla</em><sub>CTX-M-2</sub> and <em>bla</em><sub>GES-1</sub> in Extensively Drug-Resistant <em>Pseudomonas aeruginosa</em> from Cerebrospinal Fluid
    Letter to the Editor
    Plasmid Carrying blaCTX-M-2 and blaGES-1 in Extensively Drug-Resistant Pseudomonas aeruginosa from Cerebrospinal Fluid
    Anelise Stella Ballaben, Renata Galetti, Leonardo Neves Andrade, Joseane Cristina Ferreira, Doroti de Oliveira Garcia, Paulo da Silva, Yohei Doi, Ana Lucia Costa Darini
  • Combining Ceftriaxone with Doxycycline and Daptomycin Reduces Mortality, Neuroinflammation, Brain Damage, and Hearing Loss in Infant Rat Pneumococcal Meningitis
    Experimental Therapeutics
    Combining Ceftriaxone with Doxycycline and Daptomycin Reduces Mortality, Neuroinflammation, Brain Damage, and Hearing Loss in Infant Rat Pneumococcal Meningitis

    Despite appropriate antibiotic therapy, pneumococcal meningitis (PM) is associated with a case fatality rate of up to 30% in high-income countries. Survivors often suffer from severe lifelong disabilities.

    Lukas Muri, Michael Perny, Jonas Zemp, Denis Grandgirard, Stephen L. Leib
  • Isavuconazole in the Treatment of Coccidioidal Meningitis
    Clinical Therapeutics
    Isavuconazole in the Treatment of Coccidioidal Meningitis

    Patients with coccidioidal meningitis require lifelong antifungal therapy. Cumulative toxicity and lack of antifungal efficacy require salvage therapy in the treatment of some patients.

    Arash Heidari, Miriam Quinlan, David J. Benjamin, Brett Laurence, Anandit Mu, Tiffany Ngai, Wes J. Hoffman, Stuart H. Cohen, Ian McHardy, Royce Johnson, George R. Thompson
  • High-Dosage Cefazolin Achieves Sufficient Cerebrospinal Diffusion To Treat an External Ventricular Drainage-Related <em>Staphylococcus aureus</em> Ventriculitis
    Pharmacology
    High-Dosage Cefazolin Achieves Sufficient Cerebrospinal Diffusion To Treat an External Ventricular Drainage-Related Staphylococcus aureus Ventriculitis

    A patient received continuous infusion of cefazolin 10 g then 8 g daily for an external ventricular drainage-related methicillin-susceptible Staphylococcus aureus (MSSA) ventriculitis. Median free concentrations in the cerebrospinal fluid were 11.9 and 6.1 mg/liter after 10- and 8-g doses, respectively.

    Matthieu Grégoire, Benjamin Gaborit, Colin Deschanvres, Raphaël Lecomte, Guillaume Deslandes, Éric Dailly, Xavier Ambrosi, Ronan Bellouard, Nathalie Asseray, Karim Lakhal, David Boutoille
  • Clinical Therapeutics
    Treating Anthrax-Induced Meningitis in Rabbits
    Amir Ben-Shmuel, Itai Glinert, Assa Sittner, Elad Bar-David, Josef Schlomovitz, Tal Brosh, David Kobiler, Shay Weiss, Haim Levy
  • Open Access
    Pharmacology
    Repurposing and Reformulation of the Antiparasitic Agent Flubendazole for Treatment of Cryptococcal Meningoencephalitis, a Neglected Fungal Disease
    Gemma L. Nixon, Laura McEntee, Adam Johnson, Nicola Farrington, Sarah Whalley, Joanne Livermore, Cristien Natal, Gina Washbourn, Jaclyn Bibby, Neil Berry, Jodi Lestner, Megan Truong, Andrew Owen, David Lalloo, Ian Charles, William Hope

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