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methicillin-resistant Staphylococcus aureus

  • Open Access
    Adjuvant β-Lactam Therapy Combined with Vancomycin or Daptomycin for Methicillin-Resistant <span class="named-content genus-species" id="named-content-1">Staphylococcus aureus</span> Bacteremia: a Systematic Review and Meta-analysis
    Clinical Therapeutics
    Adjuvant β-Lactam Therapy Combined with Vancomycin or Daptomycin for Methicillin-Resistant Staphylococcus aureus Bacteremia: a Systematic Review and Meta-analysis

    Infections due to methicillin-resistant Staphylococcus aureus bacteremia (MRSAB) seriously threaten public health due to poor outcomes and high mortality. The objective of this study is to perform a systematic review and meta-analysis of the current evidence on adjuvant β-lactam (BL) therapy combined with vancomycin (VAN) or daptomycin (DAP) for MRSAB. PubMed, Embase...

    Chunjiang Wang, Chao Ye, Linglong Liao, Zhaohui Wang, Ying Hu, Chao Deng, Liang Liu
  • Decreased Incidence of Methicillin-Resistant <span class="named-content genus-species" id="named-content-1">Staphylococcus aureus</span> Bacteremia in Intensive Care Units: a 10-Year Clinical, Microbiological, and Genotypic Analysis in a Tertiary Hospital
    Epidemiology and Surveillance
    Decreased Incidence of Methicillin-Resistant Staphylococcus aureus Bacteremia in Intensive Care Units: a 10-Year Clinical, Microbiological, and Genotypic Analysis in a Tertiary Hospital

    There are limited long-term data on the trends in incidence and characteristics of methicillin-resistant Staphylococcus aureus (MRSA) bacteremia (MRSAB) in intensive care units (ICUs) in which infection control measures have been adopted. We evaluated the trend of incidence and changes in characteristics of MRSA bacteremia in ICUs at a tertiary-care hospital over 10 ...

    Haein Kim, Eun Sil Kim, Seung Cheol Lee, Eunmi Yang, Hee Sueng Kim, Heungsup Sung, Mi-Na Kim, Jiwon Jung, Min Jae Kim, Sung-Han Kim, Sang-Oh Lee, Sang-Ho Choi, Jun Hee Woo, Yang Soo Kim, Yong Pil Chong
  • Prolonged Exposure to β-Lactam Antibiotics Reestablishes Susceptibility of Daptomycin-Nonsusceptible <span class="named-content genus-species" id="named-content-1">Staphylococcus aureus</span> to Daptomycin
    Mechanisms of Resistance
    Prolonged Exposure to β-Lactam Antibiotics Reestablishes Susceptibility of Daptomycin-Nonsusceptible Staphylococcus aureus to Daptomycin

    Daptomycin-nonsusceptible (DAP-NS) Staphylococcus aureus often exhibits gain-in-function mutations in the mprF gene (involved in positive surface charge maintenance). Standard β-lactams, although relatively inactive against methicillin-resistant S. aureus (MRSA), may prevent the emergence...

    Rachel E. Jenson, Sarah L. Baines, Benjamin P. Howden, Nagendra N. Mishra, Sabrina Farah, Cassandra Lew, Andrew D. Berti, Sanjay K. Shukla, Arnold S. Bayer, Warren E. Rose
  • Open Access
    Scope and Predictive Genetic/Phenotypic Signatures of Bicarbonate (NaHCO<sub>3</sub>) Responsiveness and β-Lactam Sensitization in Methicillin-Resistant <span class="named-content genus-species" id="named-content-1">Staphylococcus aureus</span>
    Susceptibility
    Scope and Predictive Genetic/Phenotypic Signatures of Bicarbonate (NaHCO3) Responsiveness and β-Lactam Sensitization in Methicillin-Resistant Staphylococcus aureus

    Addition of sodium bicarbonate (NaHCO3) to standard antimicrobial susceptibility testing medium reveals certain methicillin-resistant Staphylococcus aureus (MRSA) strains to be highly susceptible to β-lactams. We investigated the prevalence of this phenotype (NaHCO3 responsiveness) to two β-lactams among 58 clinical MRSA bloodstream isolates. Of...

    Selvi C. Ersoy, Mariam Otmishi, Vanessa T. Milan, Liang Li, Youngju Pak, Jose Mediavilla, Liang Chen, Barry Kreiswirth, Henry F. Chambers, Richard A. Proctor, Yan Q. Xiong, Vance G. Fowler, Arnold S. Bayer
  • Utility of Methicillin-Resistant <span class="named-content genus-species" id="named-content-1">Staphylococcus aureus</span> Nares Screening for Patients with a Diabetic Foot Infection
    Clinical Therapeutics
    Utility of Methicillin-Resistant Staphylococcus aureus Nares Screening for Patients with a Diabetic Foot Infection

    Treatment of suspected methicillin-resistant Staphylococcus aureus (MRSA) is a cornerstone of severe diabetic foot infections; however, antibiotics can be associated with toxicity. The objective of this study was to determine the negative predictive value (NPV) of MRSA nares screening in the determination of subsequent MRSA in patients with a diabetic foot infection....

    Kari A. Mergenhagen, Michael Croix, Kaitlyn E. Starr, John A. Sellick, Alan J. Lesse
  • Open Access
    Susceptibility of Methicillin-Resistant <span class="named-content genus-species" id="named-content-1">Staphylococcus aureus</span> to Five Quinazolinone Antibacterials
    Susceptibility
    Susceptibility of Methicillin-Resistant Staphylococcus aureus to Five Quinazolinone Antibacterials

    The in vitro activities of five quinazolinone antibacterials, compounds Q1 to Q5, were tested against 210 strains of methicillin-resistant Staphylococcus aureus (MRSA). The MIC50/MIC90 values (in μg/ml) were as follows: Q1, 0.5/2; Q2, 1/4; Q3, 2/4; Q4, 0.06/0.25; and Q5, 0.125/0.5.

    Sara Ceballos, Choon Kim, Yuanyuan Qian, Shahriar Mobashery, Mayland Chang, Carmen Torres
  • Exebacase in Addition to Daptomycin Is More Active than Daptomycin or Exebacase Alone in Methicillin-Resistant <span class="named-content genus-species" id="named-content-1">Staphylococcus aureus</span> Osteomyelitis in Rats
    Experimental Therapeutics
    Exebacase in Addition to Daptomycin Is More Active than Daptomycin or Exebacase Alone in Methicillin-Resistant Staphylococcus aureus Osteomyelitis in Rats

    Bacteriophage-derived lysins are being developed as anti-infective agents. In an acute osteomyelitis methicillin-resistant Staphylococcus aureus (MRSA) model, rats receiving no treatment or treatment with daptomycin, exebacase (CF-301), or daptomycin plus exebacase had means of 5.13, 4.09, 4.65, and 3.57 log10 CFU/gram of bone, respectively.

    ...
    Melissa J. Karau, Suzannah M. Schmidt-Malan, Qun Yan, Kerryl E. Greenwood-Quaintance, Jayawant Mandrekar, Dario Lehoux, Raymond Schuch, Cara Cassino, Robin Patel
  • Identification of Small Molecules Exhibiting Oxacillin Synergy through a Novel Assay for Inhibition of <em>vraTSR</em> Expression in Methicillin-Resistant <span class="named-content genus-species" id="named-content-1">Staphylococcus aureus</span>
    Editor's Pick Biologic Response Modifiers
    Identification of Small Molecules Exhibiting Oxacillin Synergy through a Novel Assay for Inhibition of vraTSR Expression in Methicillin-Resistant Staphylococcus aureus

    Methicillin-resistant Staphylococcus aureus (MRSA) strains that are resistant to all forms of penicillin have become an increasingly common and urgent problem threatening human health. They are responsible for a wide variety of infectious diseases ranging from minor skin abscesses to life-threatening severe infections. The vra operon that is conserved among...

    Hyun Lee, Susan Boyle-Vavra, Jinhong Ren, Jamie A. Jarusiewicz, Lalit Kumar Sharma, Daniel T. Hoagland, Shaohui Yin, Tian Zhu, Kirk E. Hevener, Isabel Ojeda, Richard E. Lee, Robert S. Daum, Michael E. Johnson
  • Efficacy of Azithromycin in a Mouse Pneumonia Model against Hospital-Acquired Methicillin-Resistant <span class="named-content genus-species" id="named-content-1">Staphylococcus aureus</span>
    Experimental Therapeutics
    Efficacy of Azithromycin in a Mouse Pneumonia Model against Hospital-Acquired Methicillin-Resistant Staphylococcus aureus

    The use of macrolides against pneumonia has been reported to improve survival; however, little is known about their efficacy against methicillin-resistant Staphylococcus aureus (MRSA) pneumonia. In this study, we investigated the effect of azithromycin (AZM) and compared it with that of vancomycin (VCM) and daptomycin (DAP) in a murine model of MRSA pneumonia. Mice...

    Yu Yamashita, Kentaro Nagaoka, Hiroki Kimura, Masaru Suzuki, Satoshi Konno, Tatsuya Fukumoto, Koji Akizawa, Norihito Kaku, Yoshitomo Morinaga, Katsunori Yanagihara
  • Open Access
    Efficacy and Safety of Tedizolid Phosphate versus Linezolid in a Randomized Phase 3 Trial in Patients with Acute Bacterial Skin and Skin Structure Infection
    Clinical Therapeutics
    Efficacy and Safety of Tedizolid Phosphate versus Linezolid in a Randomized Phase 3 Trial in Patients with Acute Bacterial Skin and Skin Structure Infection

    Tedizolid phosphate is approved for the treatment of acute bacterial skin and skin structure infection (ABSSSI) caused by Gram-positive bacteria in the United States, Europe, and other countries. In this multicenter, double-blind, phase 3 study, 598 adult ABSSSI patients in China, Taiwan, the Philippines, and the United States were randomized to receive 200 mg of tedizolid, intravenously (i.v.)/orally (p.o.), once daily for 6 days or...

    Xiaoju Lv, Jeff Alder, Li Li, William O’Riordan, Michael J. Rybak, Hui Ye, Ruiping Zhang, Zhongqi Zhang, Xu Zhu, Mark H. Wilcox

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